Chinese Medicine in Fighting against Covid-19: Role and Inspiration

Li, Jingen; Xu, Hao

doi:10.1007/s11655-020-2860-x

Cited by 17 publications

(9 citation statements)

References 20 publications

(19 reference statements)

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“…Although a great quantity of review articles have been published on the topic of TCM in COVID-19 13 , 14 , 19 , 23 , 25 , 35 , 71 , 87 , 168 , 171 , 241 , 242 , 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 , 254 , 255 , 256 , 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , our work offers something unique. 1) To our knowledge, this is the first review of TCM on COVID-19 that integrates evidence-based scientific findings from bedside to bench with the most comprehensive and updated literatures.…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese medicine in COVID-19

Lyu

Fan

Xiao

et al. 2021

Acta Pharmaceutica Sinica B

148

118

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COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread across the globe, posing an enormous threat to public health and safety. Traditional Chinese medicine (TCM), in combination with Western medicine (WM), has made important and lasting contributions in the battle against COVID-19. In this review, updated clinical effects and potential mechanisms of TCM, presented in newly recognized three distinct phases of the disease, are summarized and discussed. By integrating the available clinical and preclinical evidence, the efficacies and underlying mechanisms of TCM on COVID-19, including the highly recommended three Chinese patent medicines and three Chinese medicine formulas, are described in a panorama. We hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19, but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM.

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Section: Discussionmentioning

confidence: 99%

Traditional Chinese medicine in COVID-19

Lyu

Fan

Xiao

et al. 2021

Acta Pharmaceutica Sinica B

148

118

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“…It is well recognized for prevention and treatment effects against a variety of viral infections, such as seasonal flu ( Speranza et al, 2020) , severe acute respiratory syndrome ( Lin et al, 2005) , and H1N1 flu epidemic ( Li and Tao, 2013 ; Luo et al, 2019) . As the important ingredient in the so-called Three Drugs and Three Prescriptions, the dried root of Isatis tinctoria has also been playing an active role in fighting against the novel corona virus disease 2019 (COVID-19) ( Li et al, 2020b ; Li and Xu, 2021 ). Till now, more than 300 components have been isolated from the root of Isatis indigotica , including alkaloids, sulfur-containing compounds, phenylpropanoids, amino acids, nucleosides, organic acids and esters, flavonoids, quinones, terpenes, sterols, saccharides, aromatics, peptides, alcohols, aldehydes and ketones, nitriles, and sphingolipids.…”

Section: Introductionmentioning

confidence: 99%

Microscopic Mass Spectrometry Imaging Reveals the Distribution of Phytochemicals in the Dried Root of Isatis tinctoria

et al. 2021

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The dried root of Isatis tinctoria L. (Brassicaceae) is one of the most popular traditional Chinese medicines with well-recognized prevention and treatment effects against viral infections. Above 300 components have been isolated from this herb, but their spatial distribution in the root tissue remains unknown. In recent years, mass spectrometry imaging (MSI) has become a booming technology for capturing the spatial accumulation and localization of molecules in fresh plants, animal, or human tissues. However, few studies were conducted on the dried herbal materials due to the obstacles in cryosectioning. In this study, distribution of phytochemicals in the dried root of Isatis tinctoria was revealed by microscopic mass spectrometry imaging, with application of atmospheric pressure–matrix-assisted laser desorption/ionization (AP-MALDI) and ion trap–time-of-flight mass spectrometry (IT-TOF/MS). After optimization of the slice preparation and matrix application, 118 ions were identified without extraction and isolation, and the locations of some metabolites in the dried root of Isatis tinctoria were comprehensively visualized for the first time. Combining with partial least square (PLS) regression, samples collected from four habitats were differentiated unambiguously based on their mass spectrometry imaging.

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“…Thus, there is no surprise that more than dozens of herbal formulas have been prescribed by TCM doctors in different regions of China and the world to treat the COVID-19 patients with different syndrome patterns and at different stages of the disease 75,81,83 . While the formula diversity increases the difficulty of statistical analysis for the effectiveness, many clinical studies and systemic reviews have collectively attributed the efficacy of TCM to the following major effects: repair of tissue and organ injuries, anti-inflammation, immunoregulation, and antiviral 66,71,75,81,[83][84][85][86][88][89][90][91][92][93][94][95][96][97][98] . The repair of tissue and organ injuries is apparently due to promoting the self-healing power, and anti-inflammation and immunoregulation are associated with balancing the immunity.…”

Section: Traditional Chinese Medicine (Tcm) Is a Model Of The Host-ba...mentioning

confidence: 99%

Development of a mathematic equation for host-pathogen interaction: shifting the paradigm of the pathogen-targeted medicine to the host-based medicine

Sun¹

2022

Preprint

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Prognosis of infectious diseases is determined by the dynamic interaction between hosts and pathogens. Over the past several decades, the control of pathogens has been the central dogma of treating infectious diseases in modern medicine, and little efforts have been devoted on regulation of hosts. However, the pathogen-directed medicine is now facing significant challenges, such as lack of effective antimicrobials for newly emerging pathogens, drug resistance of pathogens, and drug side-effects, etc. Here, a mathematic equation (termed the equation of host-pathogen interactions, HPI-Equation) is developed to dissect the key variables of host-pathogen interaction. It clearly shows that control of pathogens is neither necessary nor sufficient for host recovery. Instead, a combination of promoting the host self-healing power and balancing the host immune response provides the best benefit for the host. The HPI-Equation strongly suggests a paradigm shift of the pathogen-targeted medicine to the host-based medicine. Moreover, the HPI-Equation elucidates the scientific basis of traditional Chinese medicine (TCM), a model of the host-based medicine that treats infectious diseases by promoting the host self-healing power and balancing the immune response. The importance of the self-healing power elucidated in the HPI-Equation was confirmed by recent studies that the tolerance mechanism, which is discovered in plants and animals and conceptually equivalent to the self-healing power, improves host survival without directly attacking pathogens. In summary, the HPI-Equation describes the host-pathogen interaction with mathematic logics and precision; It translates the ancient wisdoms of TCM into apprehensible modern sciences and opens a new venue for integration of TCM and modern medicine for the future medicine.

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Chinese Medicine in Fighting against Covid-19: Role and Inspiration

Cited by 17 publications

References 20 publications

Traditional Chinese medicine in COVID-19

Traditional Chinese medicine in COVID-19

Microscopic Mass Spectrometry Imaging Reveals the Distribution of Phytochemicals in the Dried Root of Isatis tinctoria

Development of a mathematic equation for host-pathogen interaction: shifting the paradigm of the pathogen-targeted medicine to the host-based medicine

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