Physicochemical and transcriptomic responses of <i>Lactobacillus brevis</i><scp>JLD715</scp> to sodium selenite

Yang, Xinyan; Dai, Xiaofei; Jin, Haiyun; Lin, Guangen; Wang, Zhenghui; Song, Yang; Zhang, Wei; Man, Chaoxin; Jiang, Yujun

doi:10.1002/jsfa.11073

Cited by 8 publications

(3 citation statements)

References 34 publications

(35 reference statements)

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“…Therefore, the highly enhanced oxidoreductase activity was not unexpected . GO analysis showed that strain RC4 may metabolize nitrite by affecting its response to oxidative stress, transmembrane transport, response to stimulus, membrane, and oxidoreductase activity. , …”

Section: Resultsmentioning

confidence: 96%

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Transcriptomic Responses to Nitrite Degradation by Limosilactobacillus fermentum RC4 and Effect of ndh Gene Overexpression on Nitrite Degradation

Shi,

Che,

Sun

et al. 2023

J. Agric. Food Chem.

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The excessive nitrite residue may increase cell damage and cancer risk. Limosilactobacillu fermentum RC4 exhibited excellent nitrite degradation ability. Herein, the molecular mechanism of nitrite degradation by L. fermentum RC4 was studied by integrating scanning electron microscopy analysis, transcriptomics, and gene overexpression. The results demonstrated that the gene profile of RC4 cultured in MRS broth with 0, 100, and 300 mg/L NaNO 2 varied considerably; RC4 responded to nitrite degradation by regulating pyruvate metabolism, energy synthesis, nitrite metabolism, redox equilibrium, protein protection, and signaling. High nitrite concentrations affected the morphology of RC4 with a longer phenotype, rough and wrinkle cell and reduced cell surface hydrophobicity. Moreover, an up-regulated expression of gene ndh encoding NADH dehydrogenase, which provides electrons for nitrite reduction by catalyzing NADH, was identified when RC4 was exposed to nitrite. Overexpression of ndh in RC4 increased the nitrite degradation rate by 2−9.5% in MRS broth with 100 mg/L NaNO 2 . Thus, the findings of this study could be helpful for the application of L. fermentum to reduce nitrite residues and improve food safety in fermented food products.

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Section: Resultsmentioning

confidence: 96%

“…15 GO analysis showed that strain RC4 may metabolize nitrite by affecting its response to oxidative stress, transmembrane transport, response to stimulus, membrane, and oxidoreductase activity. 16,17 3.5. Metabolic Pathway Enrichment Analysis.…”

Section: Identification Of Degs Under Different Nitritementioning

confidence: 99%

Transcriptomic Responses to Nitrite Degradation by Limosilactobacillus fermentum RC4 and Effect of ndh Gene Overexpression on Nitrite Degradation

Shi,

Che,

Sun

et al. 2023

J. Agric. Food Chem.

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“…Lactic acid bacteria (LAB) are typically known for their probiotic properties and benefits on human health. The pharmaceutical and biomedical industries are directing their attention towards the search for LAB that produce cell-bounded and excreted biosurfactants due to their inhibitory activity against the growth of various pathogens, including bacteria, fungi and viruses [ 68 , 69 , 70 ].…”

Section: Biosurfactants As Biological Control Agentsmentioning

confidence: 99%

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Ceresa,

Fracchia,

Sansotera

et al. 2023

Pharmaceutics

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Biosurfactants (BSs) are microbial compounds that have emerged as potential alternatives to chemical surfactants due to their multifunctional properties, sustainability and biodegradability. Owing to their amphipathic nature and distinctive structural arrangement, biosurfactants exhibit a range of physicochemical properties, including excellent surface activity, efficient critical micelle concentration, humectant properties, foaming and cleaning abilities and the capacity to form microemulsions. Furthermore, numerous biosurfactants display additional biological characteristics, such as antibacterial, antifungal and antiviral effects, and antioxidant, anticancer and immunomodulatory activities. Over the past two decades, numerous studies have explored their potential applications, including pharmaceuticals, cosmetics, antimicrobial and antibiofilm agents, wound healing, anticancer treatments, immune system modulators and drug/gene carriers. These applications are particularly important in addressing challenges such as antimicrobial resistance and biofilm formations in clinical, hygiene and therapeutic settings. They can also serve as coating agents for surfaces, enabling antiadhesive, suppression, or eradication strategies. Not least importantly, biosurfactants have shown compatibility with various drug formulations, including nanoparticles, liposomes, micro- and nanoemulsions and hydrogels, improving drug solubility, stability and bioavailability, and enabling a targeted and controlled drug release. These qualities make biosurfactants promising candidates for the development of next-generation antimicrobial, antibiofilm, anticancer, wound-healing, immunomodulating, drug or gene delivery agents, as well as adjuvants to other antibiotics. Analysing the most recent literature, this review aims to update the present understanding, highlight emerging trends, and identify promising directions and advancements in the utilization of biosurfactants within the pharmaceutical and biomedical fields.

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Unraveling the molecular mechanisms of selenite reduction: transcriptomic analysis of Bacillus reveals the key role of sulfur assimilation

Yang,

Jing,

Fan

et al. 2023

Biotechnol Lett

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Physicochemical and transcriptomic responses of Lactobacillus brevisJLD715 to sodium selenite

Cited by 8 publications

References 34 publications

Transcriptomic Responses to Nitrite Degradation by Limosilactobacillus fermentum RC4 and Effect of ndh Gene Overexpression on Nitrite Degradation

Transcriptomic Responses to Nitrite Degradation by Limosilactobacillus fermentum RC4 and Effect of ndh Gene Overexpression on Nitrite Degradation

Harnessing the Potential of Biosurfactants for Biomedical and Pharmaceutical Applications

Unraveling the molecular mechanisms of selenite reduction: transcriptomic analysis of Bacillus reveals the key role of sulfur assimilation

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