Microglial Activation Modulates Neuroendocrine Secretion During Experimental Sepsis

Costa, Luís Henrique Angenendt da; Santos-Júnior, Nilton Nascimento; Catalão, Carlos Henrique Rocha; Rocha, Maria José Alves da

doi:10.1007/s12035-020-02241-5

Cited by 11 publications

(11 citation statements)

References 66 publications

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“…Sepsis induces inflammation in the central nervous system (CNS) that may cause cognitive and neuroendocrine changes (190). Brain dysfunction, including acute aberrations in vegetative or autonomic functions (191) as well as permanent alterations in sepsis survivors (192), is a hallmark of sepsis.…”

Section: Central Nervous Systemmentioning

confidence: 99%

Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

et al. 2022

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Sepsis is a potentially life-threatening systemic inflammatory syndrome characterized by dysregulated host immunological responses to infection. Uncontrolled immune cell activation and exponential elevation in circulating cytokines can lead to sepsis, septic shock, multiple organ dysfunction syndrome, and death. Sepsis is associated with high re-hospitalization and recovery may be incomplete, with long term sequelae including post-sepsis syndrome. Consequently, sepsis continues to be a leading cause of morbidity and mortality across the world. In our recent review of human chorionic gonadotropin (hCG), we noted that its major properties including promotion of fertility, parturition, and lactation were described over a century ago. By contrast, the anti-inflammatory properties of this hormone have been recognized only more recently. Vasopressin, a hormone best known for its anti-diuretic effect, also has anti-inflammatory actions. Surprisingly, vasopressin’s close cousin, oxytocin, has broader and more potent anti-inflammatory effects than vasopressin and a larger number of pre-clinical studies supporting its potential role in limiting sepsis-associated organ damage. This review explores possible links between oxytocin and related octapeptide hormones and sepsis-related modulation of pro-inflammatory and anti-inflammatory activities.

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Section: Central Nervous Systemmentioning

confidence: 99%

Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

et al. 2022

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“…Peripheral injury such as gut perforation can activate microglia in the brain. In turn, these activated microglia can modulate oxytocin release into the periphery [126]. Cecal ligation and puncture (CLP) is an animal model of sepsis due to perforated intestines.…”

Section: Microglia and Oxytocinmentioning

confidence: 99%

“…Within 6 h of CLP, circulating oxytocin levels were nearly doubled. Microglia inhibition with minocycline prevented this increase [126]. Combined, this evidence indicates that the intestinal injury activated microglia leading to an oxytocin response in adults.…”

Section: Microglia and Oxytocinmentioning

confidence: 99%

Oxytocin and microglia in the development of social behaviour

González

Hammock

2022

Phil. Trans. R. Soc. B

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Oxytocin is a well-established regulator of social behaviour. Microglia, the resident immune cells of the central nervous system, regulate brain development and maintenance in health and disease. Oxytocin and microglia interact: microglia appear to regulate the oxytocin system and are, in turn, regulated by oxytocin, which appears to have anti-inflammatory effects. Both microglia and oxytocin are regulated in sex-specific ways. Oxytocin and microglia may work together to promote experience-dependent circuit refinement through multiple developmental-sensitive periods contributing to individual differences in social behaviour. This article is part of the theme issue ‘Interplays between oxytocin and other neuromodulators in shaping complex social behaviours’.

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“…This notion is supported also by in vivo data reporting a rise in circulating oxytocin 6 h after cecal ligation and puncture in rats, a surgical method to induce sepsis. This increase in oxytocin release was prevented by pretreatment with minocycline, a tetracycline that acts also as an inhibitor of microglia reactivity [ 69 ]. Further, minocycline treatment of mice in which the oxytocin receptor gene is fully ablated (OXYR-KO) restored normal levels of the postsynaptic density protein (PSD) 95, as well as a behavioral measure of dam-pup communication, suggesting that the inhibition of microglia reactivity could ameliorate the synaptic loss seen in these mice [ 70 ].…”

Section: Oxytocin–glia Communicationmentioning

confidence: 99%

Targeting the Oxytocinergic System: A Possible Pharmacological Strategy for the Treatment of Inflammation Occurring in Different Chronic Diseases

Friuli

Eramo

Valenza

et al. 2021

IJMS

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Unresolved inflammation represents a central feature of different human pathologies including neuropsychiatric, cardiovascular, and metabolic diseases. The epidemiologic relevance of such disorders justifies the increasing interest in further understanding the mechanisms underpinning the inflammatory process occurring in such chronic diseases to provide potential novel pharmacological approaches. The most common and effective therapies for controlling inflammation are glucocorticoids; however, a variety of other molecules have been demonstrated to have an anti-inflammatory potential, including neuropeptides. In recent years, the oxytocinergic system has seen an explosion of scientific studies, demonstrating its potential to contribute to a variety of physiological processes including inflammation. Therefore, the aim of the present review was to understand the role of oxytocin in the modulation of inflammation occurring in different chronic diseases. The criterion we used to select the diseases was based on the emerging literature showing a putative involvement of the oxytocinergic system in inflammatory processes in a variety of pathologies including neurological, gastrointestinal and cardiovascular disorders, diabetes and obesity. The evidence reviewed here supports a beneficial role of oxytocin in the control of both peripheral and central inflammatory response happening in the aforementioned pathologies. Although future studies are necessary to elucidate the mechanistic details underlying such regulation, this review supports the idea that the modulation of the endogenous oxytocinergic system might represent a new potential pharmacological approach for the treatment of inflammation.

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Microglial Activation Modulates Neuroendocrine Secretion During Experimental Sepsis

Cited by 11 publications

References 66 publications

Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

Oxytocin and microglia in the development of social behaviour

Targeting the Oxytocinergic System: A Possible Pharmacological Strategy for the Treatment of Inflammation Occurring in Different Chronic Diseases

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