A risk biomarker for obstructive sleep apnea in patients with coronary artery disease: monocyte to high-density lipoprotein ratio

Role of sleep disorders in patients with cardiovascular disease: A systematic review

“…A total of 66795 references were identified in the two databases. After careful reading, 78 articles were included in this systemic review [ [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] , [87] , [88] , [89] , [90] ...…”

“… NOS high quality Low OSA probability N = 45/69 ± 14yrs High OSA probability N = 123/71 ± 12yrs 12 Feng2022 [ 43 ] Canada Prospective cohort study CAD Sleep quality N = 113/63.7 ± 6.4yrs PSQI A marker of late-stage lipid peroxidation is elevated in CAD patients with poor sleep and associated with daily disturbances, but not with other factors or with sleep quality and its factors after exercise intervention. NOS high quality Normal sleep quality N = 54/64.8 ± 6.6yrs Poor sleep quality N = 59/62.6 ± 6.1yrs 13 Huang2020 [ 41 ] China Cross-sectional study CAD OSA N = 1243 Overnight portable respiratory monitoring Elevated levels of MHR were independently associated with a higher likelihood of OSA in patients with CAD. Combie high quality MHR Quartile 1 N = 311/63.3 ± 9.1yrs MHR Quartile 2 N = 311/62.6 ± 9.5yrs MHR Quartile 3 N = 311/62.6 ± 13.0yrs MHR Quartile 4 N = 310/60.2 ± 10.8yrs 14 Juskiene2018 [ 32 ] Lithuania Cross-sectional study CAD Sleep quality OSA N = 879/58 ± 9 yrs ...…”

“…In this review, 22 studies [ [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] ] focused on sleep disorders in patients with CAD. Three studies [ [25] , [26] , [27] ] reported a high prevalence of sleep disorders in patients with CAD.…”

“…The personality disorders included type D personality, depression, anxiety, and cognition. Six studies [ [39] , [40] , [41] , [42] , [43] , [44] ] reported several biomarkers that were implicated in predicting sleep disorders in patients with CAD, such as placental growth factor (PIGF), vascular endothelial growth factor family (VEGF), high sensitivity C-reactive protein (hs-CRP) et al Three studies [ 38 , 45 , 46 ] reported that patients with CAD benefited from sleep disorder therapies, namely CPAP and inspiratory muscle training (IMT).…”

“…The monocyte-to-high-density lipoprotein ratio (MHR), which reflects the inflammatory response during CVD, is considered a new predictor of CVD. Huang et al [ 41 ] conducted a study on patients with CAD, uncovering the association between an elevated MHR and a high risk of OSA. Sorting nexins, which act on sorting membrane proteins, have been implicated in arteriosclerosis.…”