Glassy cell carcinoma of the uterine cervix: 20-year experience from a comprehensive cancer center

Boustani, Jihane; Achkar, S.; Bertaut, Aurélie; Genestie, Catherine; Gouy, Sébastien; Pautier, Patricia; Morice, Philippe; Haie-Méder, Christine; Chargari, Cyrus

doi:10.1016/j.canrad.2020.07.007

Cited by 3 publications

(6 citation statements)

References 17 publications

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“…According to the data available in the literature, patients with GCC are about 10 years younger than patients with other types of cervical cancer and the case analyzed by us confirms these observations [ 5 , 12 ]. It is highly rare tumor, but some studies have noted an association with pregnancy [ 13 , 14 ].…”

Section: Discussionsupporting

confidence: 77%

“…The cumulative 5-year OS for all stage I GCCs was 48% compared with the stage I nonglassy cell adenocarcinomas 61% [ 24 ]. Boustani et al reported 5-year OS of 85.2% in early stage tumors versus 76.4% for locally advanced cases [ 12 ]. The patient in stage IVB, described by Kosińska-Kaczyńska et al, died within six months of the diagnosis [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…PFS rates at 5 years were 86.4% (CI: 63.4–95.4) for early stage versus 75.9% (CI: 55.2–89.2) for locally advanced stages, respectively. Further, 33% patients experienced a tumor relapse and the median time was 16 months (range: 5 months to 16 years) [ 12 ]. In older studies, most recurrences were identified within 24 to 31 months of primary therapy [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

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A Unique Glassy Cell Carcinoma (GCC) of the Cervix Diagnosed during Pregnancy—A Case Report

et al. 2022

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Glassy Cell carcinoma (GCC) of the cervix is classified as a unique, aggressive neoplasm, with different sensitivity to chemotherapy and radiotherapy. It is such an extremely rare tumor that it is practically not observed during pregnancy. Information on the coexistence of cervical GCC with pregnancy is also unique, so it seems extremely important to disseminate it in order to develop the most effective treatment regimen. Additionally, making any decisions regarding therapeutic methods during pregnancy encounters great ethical problems. We present the case of a 26-year-old pregnant woman, 18 weeks gestation, diagnosed with GCC of the cervix, IB3 grade in the International Federation of Gynecology and Obstetrics (FIGO) scale. Despite the unfavorable prognosis, the use of chemotherapy in a pregnant patient brought on a favorable therapeutic effect, without any negative effects on the fetus. The article also presents a literature review on the epidemiology, pathology, immunohistochemistry, treatment and prognosis of this rare disease.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Unique Glassy Cell Carcinoma (GCC) of the Cervix Diagnosed during Pregnancy—A Case Report

et al. 2022

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“…8 and 9) (12). GCC accounts for almost 5% of all cervical cancers, 40% of which are diagnosed in reproductive-aged women (4), with a median age ranging between 28 years and 41 years, as described by Boustani et al (2), Hopkins and Morley (11) and Guitarte et al (13), respectively (2,11,13). Incidence at a younger age, with most cases presenting at early stages (stage I-II) associated with the tendency to delay motherhood nowadays, shed light on conservative and fertility-preserving strategies (2).…”

Section: Discussionmentioning

confidence: 99%

“…Cervical cancer is the fourth most common cancer in women, with an estimated yearly incidence exceeding 600,000 and a mortality rate of almost 340,000 in 2020 ( 1 ). Squamous cell carcinoma (SCC) and adenocarcinoma are the two most common histological subtypes of cervical cancer, accounting for almost 85 and 10% of all cervical cancers, respectively ( 2 ). Other histologies such as small cell, neuroendocrine, adenosquamous, and glassy cell carcinomas (GCC) represent between 3–5% of cervical cancers ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Conservative treatment of glassy cell cervical cancer: A case report

et al. 2022

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Glassy cell carcinoma (GCC) constitutes a rare yet histologically aggressive subtype of cervical cancer known for its rapid proliferation and high risk of recurrence and metastasis. Due to its low prevalence, the medical literature lacks large retrospective and prospective studies, and thus, no standardized management has been defined. The recommended treatment for GCC is radical hysterectomy with bilateral pelvic lymphadenectomy; however, since it mainly affects young women of reproductive age, data in the literature suggest conservative management, such as radical trachelectomy. The present report describes the cases of 2 young patients treated conservatively with pelvic lymphadenectomy and radical trachelectomy for early-stage GCC of the cervix. The first patient was a 37-year-old patient who presented a 15-mm GCC tumor [International Federation of Gynecology and Obstetrics (FIGO) stage IB1], and the second patient was a 23-year-old patient who presented a 14-mm GCC tumor (FIGO stage IB1). The first patient presented early vaginal recurrence 3 months postoperatively, which was treated with concomitant pelvic chemoradiation (45 Gy) followed by vaginal and uterine brachytherapy (15 Gy). The second patient presented internal iliac nodal recurrence 1 year after treatment, which was treated by carboplatin-paclitaxel-Avastin-based chemotherapy, followed by laparoscopic paraaortic lymph node dissection and pelvic chemoradiation (45 Gy). Both patients were tumor-free after 5 and 6 years, respectively. Due to the aggressiveness of GCC of the cervix and its high risk of recurrence, conservative treatment should be considered cautiously and should not be the standard of care.

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