Nodular fasciitis on the cheek of a child

Patel, Dinesh G.; Samson, Thomas D.; Cochran, Eric; Zaenglein, Andrea L.

doi:10.1111/pde.14497

Cited by 2 publications

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“…Nodular fasciitis (NF) is one such myofibroblastic proliferation that is seen most often in young adults, with fewer than 10% of estimated cases presenting in childhood. However, multiple pediatric cases have previously been reported 1–5 . Pediatric NF generally presents on the head, neck, or upper extremities and typically grows in the subcutaneous space, very rarely involving the overlying reticular dermis or deeper structures such as muscle or bone 6 .…”

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confidence: 99%

“…However, multiple pediatric cases have previously been reported. [1][2][3][4][5] Pediatric NF generally presents on the head, neck, or upper extremities and typically grows in the subcutaneous space, very rarely involving the overlying reticular dermis or deeper structures such as muscle or bone. 6 Although previously thought to be primarily a reactive phenomenon, a history of preceding trauma at the site is rarely elicited.…”

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USP6 rearrangement in pediatric nodular fasciitis

et al. 2022

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Nodular fasciitis (NF) is a myofibroblastic proliferation that is uncommonly present in pediatric patients. These benign neoplasms can masquerade as more insidious sarcomatous proliferations on both clinical exam and initial histopathologic review, often prompting undue concern in patients, parents, and providers. While immunohistochemical analysis of NF can be variable, adding to the diagnostic uncertainty, molecular analysis documenting ubiquitin‐specific protease 6 (USP6) gene rearrangement can help confirm the diagnosis as an association between NF and USP6 overexpression was first identified 10 years ago in an analysis that found rearrangements of the involved locus in over 90% of studied samples. In this report, we review one case of NF located on the chin of a nine‐year‐old girl in which molecular testing was essential to secure the correct diagnosis, and provide a summary of documented cases of USP6 overexpression in transient pediatric neoplasms.

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confidence: 99%

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USP6 rearrangement in pediatric nodular fasciitis

et al. 2022

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Nodular Fasciitis in the Preauricular Area in Pediatric Patients

Jeong

2023

Ear Nose Throat J

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Nodular fasciitis is a benign myofibroblastic and fibroblastic proliferative lesion that can be found in the subcutaneous tissue, muscle, and fascia. It is frequently observed in young adults aged 20 to 40 years and less commonly in pediatric patients. Rapid growth, high cellularity, and remarkable mitotic activity of this lesion could lead to misdiagnosis as a soft tissue sarcoma. Here, two cases of nodular fasciitis in the preauricular area in pediatric patients were reported. Nodular fasciitis in the preauricular area in a pediatric patient is rare. It could be confused with soft tissue sarcoma. However, nodular fasciitis should be suspected in a pediatric patient with a rapidly growing mass in the head and neck region. Surgical excision should be performed to confirm the histopathologic diagnosis when clinical diagnosis is uncertain and there is possibility of malignancy.

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Nodular fasciitis on the cheek of a child

Abstract: Nodular fasciitis is a benign proliferation of myofibroblastic cells affecting subcutaneous tissue, muscles, and fascia. This rare disorder is most commonly observed on the upper extremity of adults. We present a case of nodular fasciitis of the cheek of a 12-year-old girl.

Cited by 2 publications

References 5 publications

USP6 rearrangement in pediatric nodular fasciitis

USP6 rearrangement in pediatric nodular fasciitis

Nodular Fasciitis in the Preauricular Area in Pediatric Patients

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