Increased 18F-FDG accumulation in less-affected lung area in patients with non-small cell lung cancer and postoperative acute exacerbation of interstitial lung disease

Fukunaga, Kentaro; Nagatani, Yukihiro; Nakagawa, Hiroaki; Nitta-Seko, Ayumi; Nagata, Tamotsu; Nishizono, Masaki; Kobashi, Kazumasa; Iguchi, Harumi; Nitta, Norihisa; Hanaoka, Jun; Murata, Kiyoshi; Watanabe, Yoshiyuki; Nakano, Yasutaka

doi:10.1016/j.ejrad.2020.109477

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…In IPF patients, PET/CT scans have been widely studied and found to be valuable for the evaluation of disease activity and therapy efficacy as well as the prediction of disease progression and survival [31,33,34]. In patients with lung cancer, elevated pulmonary FDG uptake is associated with acute exacerbation of ILD after chemotherapy or surgery [35][36][37]. In Ssc-ILD patients, pulmonary FDG uptake is correlated with ILD severity [13].…”

Section: Discussionmentioning

confidence: 99%

The lungs were on fire: a pilot study of 18F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease

Liang

Liu

et al. 2021

Arthritis Res Ther

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Background Interstitial lung disease (ILD) and its rapid progression (RP) are the main contributors to unfavourable outcomes of patients with idiopathic inflammatory myopathy (IIM). This study aimed to identify the clinical value of PET/CT scans in IIM-ILD patients and to construct a predictive model for RP-ILD. Methods Adult IIM-ILD patients who were hospitalized at four divisions of the First Affiliated Hospital, Zhejiang University School of Medicine (FAHZJU), from 1 January 2017 to 31 December 2020 were reviewed. PET/CT scans and other characteristics of patients who met the inclusion and exclusion criteria were collected and analysed. Results A total of 61 IIM-ILD patients were enrolled in this study. Twenty-one patients (34.4%) developed RP-ILD, and 24 patients (39.3%) died during follow-up. After false discovery rate (FDR) correction, the percent-predicted diffusing capacity of the lung for carbon monoxide (DLCO%, P = 0.014), bilateral lung mean standard uptake value (SUVmean, P = 0.014) and abnormal mediastinal lymph node (P = 0.045) were significantly different between the RP-ILD and non-RP-ILD groups. The subsequent univariate and multivariate logistic regression analyses verified our findings. A “DLM” model was established by including the above three values to predict RP-ILD with a cut-off value of ≥ 2 and an area under the curve (AUC) of 0.905. Higher bilateral lung SUVmean (P = 0.019) and spleen SUVmean (P = 0.011) were observed in IIM-ILD patients who died within 3 months, and a moderate correlation was recognized between the two values. Conclusions Elevated bilateral lung SUVmean, abnormal mediastinal lymph nodes and decreased DLCO% were significantly associated with RP-ILD in IIM-ILD patients. The “DLM” model was valuable in predicting RP-ILD and requires further validation.

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Section: Discussionmentioning

confidence: 99%

The lungs were on fire: a pilot study of 18F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease

Liang

Liu

et al. 2021

Arthritis Res Ther

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“…Umeda et al proposed that the positive retention index of SUV, based on SUV obtained after one-hour and three-hour imaging in 50 patients, e ciently predicted early progression of pulmonary function impairment [35]. In patients suffering from lung cancer, elevated pulmonary FDG uptake was associated with acute exacerbation of ILD after chemotherapy or surgery [36][37][38]. In Ssc-ILD patients, pulmonary FDG uptake was correlated with ILD severity [14].…”

Section: Discussionmentioning

confidence: 99%

The lungs were on fire: a pilot study of 18F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease

Liang

Cao

Liu

et al. 2021

Preprint

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Background: Interstitial lung disease (ILD) and its rapid progression (RP) were main contributors to unfavorable outcome of idiopathic inflammatory myopathy (IIM) patients. This study aimed at identifying the clinical value of PET/CT scan in IIM-ILD patients as well as constructing a predicting model for RP-ILD.Methods: Adult IIM-ILD patients who were hospitalized at four divisions of the First Affiliated Hospital, Zhejiang University School of Medicine (FAHZJU) from Jannuary 1st 2017 to December 31st 2020 were reviewed. PET/CT scan as well as other factors of patients who met the inclusion and exclusion criteria were collected and analyzed.Results: A total of 61 IIM-ILD patients were finally enrolled into this study. Twenty-one patients (34.4%) developed RP-ILD and 24 patients (39.3%) died in follow-up. After false discovery rate (FDR) correction, percent-predicted diﬀusing capacity of the lung for carbon monoxide (DLCO%, P=0.014), bilateral lung mean standard uptake value (SUVmean, P=0.014) and abnormal mediastinal lymph node (P=0.045) were significantly different in comparison between RP-ILD and non-RP-ILD groups. A “DLM” model was hereby established by including the above three values to predict RP-ILD with a cutoff value of ≥2 and an area under the curve (AUC) of 0.905. Higher bilateral lung SUVmean (P=0.019) and spleen SUVmean (P=0.011) were observed in IIM-ILD patients who died within three months, and a moderate correlation was recognized between the two values. Conclusions: Elevated bilateral lung SUVmean and abnormal mediastinal lymph node were associated with RP-ILD in IIM-ILD patients. The “DLM” model was valuable in predicting RP-ILD and demanded further evaluation.

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“…For example, Fukunaga et al investigated whether 18 F-FDG accumulation in normal or less-affected lungs with PF increased in 36 lung cancer patients with postoperative AE of PF, compared to 50 patients without PF on pre-operative PET/CT evaluation. 18 F-FDG-PET/CT demonstrated increased SUV mean as well as elevated SUV TF in normal or less-affected lungs for lung cancer patients with AE potentially reflecting regional fibrosis and inflammatory change [69]. Yamamichi et al aimed to investigate whether the SUV max was useful in assessing the postoperative risk of AE and severe respiratory adverse events in patients with lung cancer after surgical resection, including a subset of 120 patients with PF.…”

Section: Cross-application Of Pet Imaging Between Cancer and Fibrosismentioning

confidence: 99%

Imaging at the nexus: how state of the art imaging techniques can enhance our understanding of cancer and fibrosis

Baniasadi,

Das,

Prendergast

et al. 2024

J Transl Med

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Both cancer and fibrosis are diseases involving dysregulation of cell signaling pathways resulting in an altered cellular microenvironment which ultimately leads to progression of the condition. The two disease entities share common molecular pathophysiology and recent research has illuminated the how each promotes the other. Multiple imaging techniques have been developed to aid in the early and accurate diagnosis of each disease, and given the commonalities between the pathophysiology of the conditions, advances in imaging one disease have opened new avenues to study the other. Here, we detail the most up-to-date advances in imaging techniques for each disease and how they have crossed over to improve detection and monitoring of the other. We explore techniques in positron emission tomography (PET), magnetic resonance imaging (MRI), second generation harmonic Imaging (SGHI), ultrasound (US), radiomics, and artificial intelligence (AI). A new diagnostic imaging tool in PET/computed tomography (CT) is the use of radiolabeled fibroblast activation protein inhibitor (FAPI). SGHI uses high-frequency sound waves to penetrate deeper into the tissue, providing a more detailed view of the tumor microenvironment. Artificial intelligence with the aid of advanced deep learning (DL) algorithms has been highly effective in training computer systems to diagnose and classify neoplastic lesions in multiple organs. Ultimately, advancing imaging techniques in cancer and fibrosis can lead to significantly more timely and accurate diagnoses of both diseases resulting in better patient outcomes.

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Increased 18F-FDG accumulation in less-affected lung area in patients with non-small cell lung cancer and postoperative acute exacerbation of interstitial lung disease

Cited by 3 publications

References 22 publications

The lungs were on fire: a pilot study of 18F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease

The lungs were on fire: a pilot study of 18F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease

The lungs were on fire: a pilot study of 18F-FDG PET/CT in idiopathic-inflammatory-myopathy-related interstitial lung disease

Imaging at the nexus: how state of the art imaging techniques can enhance our understanding of cancer and fibrosis

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