Abstract:Brincidofovir (BCV) is an investigational lipid conjugate of the nucleotide analog cidofovir (CDV), which is being developed as a medical countermeasure for the treatment of smallpox. BCV is active against double‐stranded DNA viruses including BK and JC viruses. Here, we validated procedures for quantifying BCV and its pharmacologically active moiety cidofovir diphosphate (CDV‐PP) in mouse kidney, brain and spleen tissue homogenates. Following homogenization, BCV and CDV‐PP were extracted from the tissues by p… Show more
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