DCs-based therapies: potential strategies in severe SARS-CoV-2 infection

Han, Jian; Sun, Jiazhi; Zhang, Guixin; Chen, Hailong

doi:10.7150/ijms.47706

Cited by 11 publications

(10 citation statements)

References 126 publications

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“…As a result, the cross-reactive T cell response may lead to a downward trend in MERS-CoV titer [ 43 ]. Besides, during MERS-CoV infection, the virus attacks the immune system and downregulates MHC-I, MHC-II, and CD80/86 in antigen-presenting cells (APC), which in consequence inhibits T cell response [ 44 ]. Recently, the induction of immune system suppression during MERS-CoV infection employing promotion T cell apoptosis has been recognized as another way to manipulate the host immune responses for surviving the virus [ 45 ].…”

Section: Adaptive Immune Response In Sars and Mers Infectionmentioning

confidence: 99%

Comparison of Immune Response between SARS, MERS, and COVID-19 Infection, Perspective on Vaccine Design and Development

Ansariniya

Seifati

Zaker

et al. 2021

BioMed Research International

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Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Coronavirus Disease 2019 (COVID-19) infections are the three epidemiological diseases caused by the Coronaviridae family. Perceiving the immune responses in these infections and the escape of viruses could help us design drugs and vaccines for confronting these infections. This review investigates the innate and adaptive immune responses reported in the infections of the three coronaviruses SARS, MERS, and COVID-19. Moreover, the present study can trigger researchers to design and develop new vaccines and drugs based on immune system responses. In conclusion, due to the need for an effective and efficient immune stimulation against coronavirus, a combination of several strategies seems necessary for developing the vaccine.

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Section: Adaptive Immune Response In Sars and Mers Infectionmentioning

confidence: 99%

Comparison of Immune Response between SARS, MERS, and COVID-19 Infection, Perspective on Vaccine Design and Development

Ansariniya

Seifati

Zaker

et al. 2021

BioMed Research International

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show abstract

“…They effectively sense intracellular viral RNA via TLRs and produce large amounts of type I and III IFNs [44]. Any DC that is not a pDC is referred to as a conventional DC (cDC), and peripheral blood studies show depletion of cDCs in COVID-19 patients suffering from ARDS [45]. Mature DCs can stimulate helper CD4 + and cytotoxic CD8 + T-cell memory, and SARS-CoV-2 has been shown to target DCs directly to limit their maturation, resulting in a delayed immune response [6,45].…”

Section: Dendritic Cellsmentioning

confidence: 99%

“…Any DC that is not a pDC is referred to as a conventional DC (cDC), and peripheral blood studies show depletion of cDCs in COVID-19 patients suffering from ARDS [45]. Mature DCs can stimulate helper CD4 + and cytotoxic CD8 + T-cell memory, and SARS-CoV-2 has been shown to target DCs directly to limit their maturation, resulting in a delayed immune response [6,45]. Studies report a slight increase in mature DCs from bronchoalveolar lavage fluid analysis, suggesting that they participate in the anti-SARS-CoV-2 immune response in the lungs [46].…”

Section: Dendritic Cellsmentioning

confidence: 99%

Can the immune system be targeted to treat COVID-19?

Abdelhafeez¹,

Doherty²

2021

Covid-19

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“…Based on those studies, DCs were regarded as a critical role in revealing how the host defends itself against invasion by SARS-CoV-2. Recently, Han et al proposed that the dendritic cell-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection [ 53 ].…”

Section: Introductionmentioning

confidence: 99%

The molecular mechanism of SARS-CoV-2 evading host antiviral innate immunity

Gan

et al. 2022

Virol J

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The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a global health emergency (COVID-19) because of its rapid spread and high mortality. Since the virus epidemic, many pathogenic mechanisms have been revealed, and virus-related vaccines have been successfully developed and applied in clinical practice. However, the pandemic is still developing, and new mutations are still emerging. Virus pathogenicity is closely related to the immune status of the host. As innate immunity is the body’s first defense against viruses, understanding the inhibitory effect of SARS-CoV-2 on innate immunity is of great significance for determining the target of antiviral intervention. This review summarizes the molecular mechanism by which SARS-CoV-2 escapes the host immune system, including suppressing innate immune production and blocking adaptive immune priming. Here, on the one hand, we devoted ourselves to summarizing the combined action of innate immune cells, cytokines, and chemokines to fine-tune the outcome of SARS-CoV-2 infection and the related immunopathogenesis. On the other hand, we focused on the effects of the SARS-CoV-2 on innate immunity, including enhancing viral adhesion, increasing the rate of virus invasion, inhibiting the transcription and translation of immune-related mRNA, increasing cellular mRNA degradation, and inhibiting protein transmembrane transport. This review on the underlying mechanism should provide theoretical support for developing future molecular targeted drugs against SARS-CoV-2. Nevertheless, SARS-CoV-2 is a completely new virus, and people’s understanding of it is in the process of rapid growth, and various new studies are also being carried out. Although we strive to make our review as inclusive as possible, there may still be incompleteness.

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DCs-based therapies: potential strategies in severe SARS-CoV-2 infection

Cited by 11 publications

References 126 publications

Comparison of Immune Response between SARS, MERS, and COVID-19 Infection, Perspective on Vaccine Design and Development

Comparison of Immune Response between SARS, MERS, and COVID-19 Infection, Perspective on Vaccine Design and Development

Can the immune system be targeted to treat COVID-19?

The molecular mechanism of SARS-CoV-2 evading host antiviral innate immunity

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