Tripterygium wilfordii Hook F. in the treatment of synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a clinical trial

Wang, Lun; Gong, Liang; Zhang, Xinlu; Cao, Yihan; Long, Piaopiao; Zhang, Wen; Zeng, Xiaofeng; Li, Chen

doi:10.1007/s10067-020-05562-x

Cited by 11 publications

(12 citation statements)

References 39 publications

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“…Antibiotics gave clinical improvement in one study, but pain recurred after discontinuation [ 24 ]. In other studies, Tripterygium wilfordii and tonsillectomy (in patients with concomitant tonsillitis) caused significant improvement of bone pain [ 22 , 23 ].…”

Section: Resultsmentioning

confidence: 98%

Clinical and therapeutic diversity in adult chronic nonbacterial osteomyelitis (CNO) of the sternocostoclavicular region: a meta-analysis

Leerling

Dekkers²,

Appelman‐Dijkstra

et al. 2022

Rheumatology

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Objectives Chronic nonbacterial osteomyelitis (CNO) is a rare inflammatory bone disease. The distinct CNO subtype that affects the anterior chest wall is descriptively named sternocostoclavicular hyperostosis (SCCH) and mainly occurs in adults. Literature on CNO/SCCH is scattered, and lacks diagnostic and therapeutic consensus. Methods Systematic review and meta-analysis aiming to characterize 1) clinical presentation and i2) therapeutic modalities applied in adult CNO/SCCH patients. Untransformed numerical data and double-arcsine transformed proportional data were pooled in a random effects model in R-4.0.5; proportions were reported with 95% confidence intervals(95%CI). Results 40 studies were included, containing data on 2030 and 642 patients for aim 1 and 2 respectively. A female predisposition (67%, 95%CI60-73) and major diagnostic delay (5 years 95%CI3-7) were noted. Clinical presentation included chest pain (89%, 95%CI79-96), and swelling (79%, 95%CI62-91). Patients suffered from pustulosis palmoplantaris (53%, 95%CI37-68), arthritis (24%, 95%CI 11–39) and acne (8%, 95%CI4-13). Inflammatory markers were inconsistently elevated. Autoantibody and HLA-B27 prevalence was normal, and histopathology unspecific. Increased isotope uptake (99%, 95%CI96-100) was a consistent imaging finding. Amongst manifold treatments, pamidronate and biologicals yielded good response in 83%, 95%CI60-98 and 56%, 95%CI26-85 respectively. Conclusion CNO/SCCH literature proves heterogeneous regarding diagnostics and treatment. Timely diagnosis is challenging and mainly follows from increased isotope uptake on nuclear examination. Biopsies, autoantibodies and HLA-status are non-contributory, and biochemical inflammation only variably detected. Based on reported data, bisphosphonates and biologicals seem reasonably effective, but due to limitations in design and heterogeneity between studies the precise magnitude of their effect is uncertain. Fundamentally, international consensus seems imperative to advance clinical care for CNO/SCCH.

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Section: Resultsmentioning

confidence: 98%

Clinical and therapeutic diversity in adult chronic nonbacterial osteomyelitis (CNO) of the sternocostoclavicular region: a meta-analysis

Leerling

Dekkers²,

Appelman‐Dijkstra

et al. 2022

Rheumatology

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“…The patients achieved significant changes from baseline in ASDAS, visual analogue scale in global osteoarticular pain, bath Ankylosing Spondylitis Disease Activity Index, and other efficacy measures. 79 Remission of osteoarticular are reported by Li et al 80 Three case reports showed osteoarticular or cutaneous symptoms of SAPHO patients improved in response to TwHF. 39 , 80 , 81 Bisphosphonates inhibit bone resorption and have some anti-inflammatory properties.…”

Section: Biologics In Sapho Syndromementioning

confidence: 94%

New Insights in the Treatment of SAPHO Syndrome and Medication Recommendations

Cheng¹,

Li²,

Tian³

et al. 2022

JIR

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Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare autoinflammatory disease characterized by dermatological disorders and osteoarticular inflammatory lesions. This article reviews the application of biologics and other treatments based on the therapeutic target and the size of molecules in SAPHO syndrome. We found that drugs, especially biologics, have different effects on bone, joint, and skin damage. This may relate to the different inflammatory pathways involved in the osteoarticular and cutaneous symptoms in SAPHO patients. In this study, we provide stratified medication recommendations for SAPHO syndrome. Patients with osteoarticular symptoms can consider tumor necrosis factor blockers, JAK inhibitor, interleukin (IL)-1 inhibitor, and IL-17 inhibitor. Patients with cutaneous symptoms should consider IL-17 and JAK inhibitors. Apremilast, Tripterygium wilfordii Hook F, and bisphosphonates are other effective treatments.

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“…Although China ranked first in citation frequency (16,371) and H-index (53), it ranked lowest in citations per publication (14.43) among the 10 countries. The United States ranked high in citation frequency (11,782), H-index (49), and citations per publication (51.23) among the 10 countries.…”

Section: Country/institution Cooperation Network Relationshipsmentioning

confidence: 99%

“…[6][7][8][9] In this paper, several natural products that have effects on arthritis were found through visual analysis. For example, Tripterygium wilfordii Hook.f., [10,11] turmeric, [12,13] and Siegesbeckia orientalis L. [14] are commonly used in anti-arthritis research.…”

Section: Introductionmentioning

confidence: 99%

Trends and frontiers in natural products for arthritis, 2000–2021: A bibliometric analysis

2022

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Background: Arthritis has become one of the trouble diseases that upsets people. A growing number of studies have shown that natural products have great potential for the treatment of arthritis. However, few bibliometrics have been systematically studied in this area. This paper analyzes the literature data of natural products on the arthritis research, and the research hot spots and future research directions of the treatment of arthritis by natural products were explored. Method: Through CiteSpace, VOSviewer software and Bibliometricx under the R language environment, the article and review literatures on the treatment of arthritis with natural drugs in the Web of Science core collection database were analyzed by bibliometric analysis. Results: On December 28, 2021, a total of 2102 records were retrieved, 81.69% publications were issued in 2012 to 2021, mainly in China-dominated Asian countries, with cooperation among countries. The analysis of the number of articles published by institutions shows that the number of articles published by China Academy of Chinese Medical Sciences is up to 82. Lu, Aiping and Smolen, JS are the authors with the highest citation frequency and co-citation frequency. Keywords analysis showed that the research of natural drugs mainly focused on gene expression, anti-inflammatory and other mechanisms and signaling pathways. With the progress of science and technology and the integration of multi-disciplines, the research on natural drugs for arthritis will be more in-depth and specific. Conclusion: In this study, literature metrology analysis was conducted on natural products in the treatment of arthritis, in order to grasp the background, trends and frontiers of the research, and predict possible research hotspots in the future. It is expected to provide some reference value and direction for future scholars in this field.

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Tripterygium wilfordii Hook F. in the treatment of synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a clinical trial

Cited by 11 publications

References 39 publications

Clinical and therapeutic diversity in adult chronic nonbacterial osteomyelitis (CNO) of the sternocostoclavicular region: a meta-analysis

Clinical and therapeutic diversity in adult chronic nonbacterial osteomyelitis (CNO) of the sternocostoclavicular region: a meta-analysis

New Insights in the Treatment of SAPHO Syndrome and Medication Recommendations

Trends and frontiers in natural products for arthritis, 2000–2021: A bibliometric analysis

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