Cyclodextrins based delivery systems for macro biomolecules

Liu, Jiang; Ding, Xin Hua; Fu, Yupeng; Xiang, Cen; Yuan, Yuan; Zhang, Yongmin; Yu, Peng

doi:10.1016/j.ejmech.2020.113105

Cited by 20 publications

(11 citation statements)

References 139 publications

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“…Meanwhile, the dissolution of lipids from biomembranes through complexation with CDs, especially methyl-β-CD and HP-β-CD, may be useful in the study of cellular biology, e.g., caveolae, lipid rafts, and cholesterol transport. It is not certain that CDs are not polymers, but it is acknowledged that CD-containing polymers and CD conjugates with cationic polymers such as polyethyleneimine (PEI) and starburst polyamidoamine (PAMAM) dendrimers (PAMAM dendrimers), and CD-based supramolecules such as polyrotaxanes (PRX) and polypseudorotaxanes (PPRX) with linear polymers have been utilizing as carriers for delivery for gene and oligonucleotide drugs [ 20 , 21 , 22 , 23 ]. Additionally, CD-based supramolecular nanoassemblies that are sensitive to chemical, biological, and physical stimuli have been designed and developed [ 24 ].…”

Section: Cyclodextrins Conjugates With Pamam Dendrimers For Gene and Oligonucleotide Drug Deliverymentioning

confidence: 99%

Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers

Arima

2021

Pharmaceutics

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Recently, the number of gene and oligonucleotide drugs are increasing. Of various drug delivery systems (DDSs) for gene and oligonucleotide drugs, few examples of the clinical application of polymer as drug carriers are known, despite development of the novel polymers has been progressing. Cyclodextrin (CD) conjugates with starburst polyamidoamine (PAMAM) dendrimer (CDEs), as a new type of polymer-based carriers, were first published in 2001. After that, galactose-, lactose-, mannose-, fucose-, folate-, and polyethyleneglycol (PEG)-appended CDEs have been prepared for passive and active targeting for gene, oligonucleotide, and low-molecular-weight drugs. PEG-appended CDE formed polypsuedorotaxanes with α-CD and γ-CD, which are useful for a sustained release system of gene and oligonucleotide drugs. Interestingly, CDEs were found to have anti-inflammatory effects and anti-amyloid effects themselves, which have potential as active pharmaceutical ingredients. Most recently, CDE is reported to be a useful Cas9-RNA ribonucleoproteins (Cas9 RNP) carrier that induces genome editing in the neuron and brain. In this review, the history and progression of CDEs are overviewed.

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Section: Cyclodextrins Conjugates With Pamam Dendrimers For Gene and Oligonucleotide Drug Deliverymentioning

confidence: 99%

Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers

Arima

2021

Pharmaceutics

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“…The thermo‐mechanical properties of cyclodextrin‐based gels have recently attracted noticeable attention because these materials are biocompatible and non‐cytotoxic 67,68 . Due to the ability of cyclodextrin to form supramolecular bonds based on the host–guest inclusion complexation, these gels are widely used for the controlled delivery of proteins and nucleic acids 69 …”

Section: Fitting Of Experimental Datamentioning

confidence: 99%

A model for equilibrium swelling of the upper critical solution temperature type thermoresponsive hydrogels

Drozdov

Christiansen

2021

Polymer International

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Thermoresponsive gels of the upper critical solution temperature (UCST) type shrink below their critical temperature and swell above it. Changes in water uptake by these gels are driven by thermally induced dissociation of hydrogen or ionic bonds between chains. A simple model is developed for the description of the equilibrium swelling of thermophilic gels with hydrogen bonds. To confirm its ability to describe observations, equilibrium swelling diagrams are fitted on poly(acrylamide‐acrylic acid) and poly(acrylamide‐acrylonitrile) macroscopic gels and microgels with various structures (copolymer gels, gels with interpenetrating networks, nanocomposite gels), as well as on biocompatible poly(N‐acryloyl‐glycinamide) and poly(allylurea‐co‐allylamine) gels. Numerical simulation reveals that material parameters evolve consistently with molar fractions of crosslinker, hydrophobic and hydrophilic comonomers in the feed, degree of ionization of functional groups, and concentration of nanofiller. It is shown that the model can also be applied to describe observations on thermophilic zwitterionic gels. © 2021 Society of Industrial Chemistry.

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“…Acting as cyclic sugar oligomers composed of glucose monomers, the CDs not only have excellent biocompatibility but also the capability of encapsulating a variety of hydrophobic molecules through host-guest interactions due to its hydrophobic inner F I G U R E 1 Schematic illustration of nanopore sensing for γ-CD induced host-guest interaction to reverse binding of PFOA to HSA cavity [13]. These features make CDs one of the best candidates for hydrophobic drug delivery [14] and surfactant removal [13,15]. For example, β-CD can encapsulate PFOA strongly in a host-guest complex without being disturbed by changes in solution [16].…”

Section: Introductionmentioning

confidence: 99%

Nanopore sensing of γ‐cyclodextrin induced host‐guest interaction to reverse the binding of perfluorooctanoic acid to human serum albumin

2021

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Perfluorooctanoic acid (PFOA) has been one of the most common perfluorochemicals, which are globally pervasive contaminants that are persistent, bioaccumulative, toxic, and have adverse impacts on human health. The highest concentration of PFOA occurs in the blood, where it strongly binds to human serum albumins (HSA). Thus, a method to reverse the HSA-PFOA binding is critical to help facilitate the faster elimination of PFOA from the body to minimize its toxicological effects. Inspired by the remediation effect of cyclodextrin (CD) to PFOA through host-guest interactions, herein, by elucidating inter-molecular interactions using a nanopore sensor, we demonstrated in vitro reversal of the binding of PFOA to HSA using γ-cyclodextrin (γ-CD). The competition behavior for the complexation of PFOA between HSA and γ-CD was discussed in combination with in situ nanopore current recording and nuclear magnetic resonance (NMR) characterization. The present work not only demonstrates the potential therapeutic application of γ-CD for PFOA removal from human blood, but also provides an emerging method for investigating interactions between organic compounds and proteins.

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Cyclodextrins based delivery systems for macro biomolecules

Cited by 20 publications

References 139 publications

Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers

Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers

A model for equilibrium swelling of the upper critical solution temperature type thermoresponsive hydrogels

Nanopore sensing of γ‐cyclodextrin induced host‐guest interaction to reverse the binding of perfluorooctanoic acid to human serum albumin

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