Fabrication and in-vitro characterization of a polymeric aortic valve for minimally invasive valve replacement

Cavallo, Alessia; Gasparotti, Emanuele; Losi, Paola; Foffa, Ilenia; Kayal, Tamer Al; Vignali, Emanuele; Celi, Simona; Soldani, Giorgio

doi:10.1016/j.jmbbm.2020.104294

Cited by 17 publications

(4 citation statements)

References 30 publications

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“…Given this aspect, the adoption of biomimetic valves and prosthetic devices may set another improvement of the pump performances. 29,30 It is worth stressing out that the adoption of different interpolation points, based on physiologic cardiac events, provided a satisfactory level of customization. The tests demonstrated that this approach is versatile enough to cover a wide range of cases, from both adults and pediatrics cases.…”

Section: Discussionmentioning

confidence: 99%

High-Versatility Left Ventricle Pump and Aortic Mock Circulatory Loop Development for Patient-Specific Hemodynamic In Vitro Analysis

et al. 2022

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The importance of experimental setups able to reproduce cardiac functions was well established in the field of clinical innovations. The mock circulatory loops acquired rising relevance, and the possibility to have a complete reproduction of different and specific fluid dynamic conditions within the setup is pivotal. A system with enough versatility to reproduce the physiologic range of both flows and pressures is required. This study describes the design of a versatile setup composed by a custom pulsatile left ventricular pump system and a 3D-printed mock circulatory loop for the in vitro analysis of a patient-specific case of an aortic complex. The performances of the pump were validated first with a set of test flow profiles. It was demonstrated that the system was able to cover a wide range of aortic and mitral flows. Second, the pump system was inserted within the full mock circulatory loop. A patient-specific case was reproduced, both in terms of flow and pressure profiles. A successful validation of the flow and pressure waveforms was obtained by using patient-specific in vivo data from magnetic resonance analysis. ASAIO

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Section: Discussionmentioning

confidence: 99%

High-Versatility Left Ventricle Pump and Aortic Mock Circulatory Loop Development for Patient-Specific Hemodynamic In Vitro Analysis

et al. 2022

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“…Even if the presented technique was designed for mechano-biological analysis for soft biological tissues, its customizability allows the usage in other biomedical fields, such as vascular grafts and cardiovascular valves prostheses [48,49]. The results derived from this approach will permit to quantify and interpret the effect of fiber distribution for mechanical constitutive modeling [43].…”

Section: Discussionmentioning

confidence: 99%

Development and Realization of an Experimental Bench Test for Synchronized Small Angle Light Scattering and Biaxial Traction Analysis of Tissues

et al. 2021

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Insights into the mechanical and microstructural status of biological soft tissues are fundamental in analyzing diseases. Biaxial traction is the gold standard approach for mechanical characterization. The state of the art methods for microstructural assessment have different advantages and drawbacks. Small angle light scattering (SALS) represents a valuable low energy technique for soft tissue assessment. The objective of the current work was to develop a bench test integrating mechanical and microstructural characterization capabilities for tissue specimens. The setup’s principle is based on the integration of biaxial traction and SALS analysis. A dedicated control application was developed with the objective of managing the test procedure. The different components of the setup are described and discussed, both in terms of hardware and software. The realization of the system and the corresponding performances are then presented.

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“…[21][22][23] Recent research on prosthetic valves focused on applying modifications to PU, 10,24 and different research groups reported in vitro and in vivo tests with valves made of polycarbonate urethane (PCU), 20,25 composites thereof, [26][27][28][29] and siloxane-based PUs. 30,31 In 2021, Foldax used the LifePolymer™, a siloxane poly(urethane-urea) (SiPUU), to develop the Tria valve, the first polymeric valve implanted in patients. 24 However, long-term prosthesis performance has not been demonstrated yet.…”

Section: Introductionmentioning

confidence: 99%

Design, manufacturing and testing of a green non-isocyanate polyurethane prosthetic heart valve

Melo,

Nondonfaz,

Aqil

et al. 2024

Biomater. Sci.

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Fabrication and in-vitro characterization of a polymeric aortic valve for minimally invasive valve replacement

Cited by 17 publications

References 30 publications

High-Versatility Left Ventricle Pump and Aortic Mock Circulatory Loop Development for Patient-Specific Hemodynamic In Vitro Analysis

High-Versatility Left Ventricle Pump and Aortic Mock Circulatory Loop Development for Patient-Specific Hemodynamic In Vitro Analysis

Development and Realization of an Experimental Bench Test for Synchronized Small Angle Light Scattering and Biaxial Traction Analysis of Tissues

Design, manufacturing and testing of a green non-isocyanate polyurethane prosthetic heart valve

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