Association Between Preoperative Blood Transfusion and Postoperative Venous Thromboembolism: Review Meta-Analysis

Tissue plasminogen activator resistance is an early predictor of posttraumatic venous thromboembolism: A prospective study from the CLOTT research group

“…At 24 hours, brain injuries, pelvic fractures, and those undergoing major surgery during the first 24 hours are most at risk for displaying SD or tPA-R. A review of the data in Tables 2, 3, and 4 would suggest that transfusions of RBCs, plasma, platelets, and cryoprecipitate could be implicated as causative factors contributing to the inability to lyse clot. Perioperative blood transfusions have been associated with postoperative VTE in other fields of surgery with an estimated odds ratio of 2.95 36,37 . It has been proposed that transfused blood acts as a modulator of the inflammatory cascade and thus contributes of hypercoagulation.…”

“…Perioperative blood transfusions have been associated with postoperative VTE in other fields of surgery with an estimated odds ratio of 2.95. 36,37 It has been proposed that transfused blood acts as a modulator of the inflammatory cascade and thus contributes of hypercoagulation. A previous study in trauma patients by Schultz et al 38 found that patients who had been transfused with RBCs had more than three times the risk of developing VTE compared with those without transfusions, although the number of units of blood is not mentioned in that study.…”