Associations between red blood cells fatty acids, desaturases indices and metabolism of platelet activating factor in healthy volunteers

Fragopoulou, Elizabeth; Detopoulou, Paraskevi; Alepoudea, E.; Nomikos, Tzortzis; Kalogeropoulos, Nick; Antonopoulou, Smaragdi

doi:10.1016/j.plefa.2020.102234

Cited by 18 publications

(8 citation statements)

References 49 publications

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“…It is noted that Lp-PLA 2 , increases as a result of increased PAF in order to catabolize it, thus, the trend for an inverse association of Lp-PLA 2 with omega-3 fatty acids, implies a negative association with PAF. Moreover, results from a cross-sectional study of our group have shown that omega-6 fatty acids were positively correlated with PAF-CPT while no significant correlations were observed with omega-3 fatty acids and PAF or its enzymes [111].…”

Section: Omega-3 Fatty Acidsmentioning

confidence: 79%

Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism

2021

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The new coronavirus disease 2019 (COVID-19) pandemic is an emerging situation with high rates of morbidity and mortality, in the pathophysiology of which inflammation and thrombosis are implicated. The disease is directly connected to the nutritional status of patients and a well-balanced diet is recommended by official sources. Recently, the role of platelet activating factor (PAF) was suggested in the pathogenesis of COVID-19. In the present review several micronutrients (vitamin A, vitamin C, vitamin E, vitamin D, selenium, omega-3 fatty acids, and minerals), phytochemicals and Mediterranean diet compounds with potential anti-COVID activity are presented. We further underline that the well-known anti-inflammatory and anti-thrombotic actions of the investigated nutrients and/or holistic dietary schemes, such as the Mediterranean diet, are also mediated through PAF. In conclusion, there is no single food to prevent coronavirus Although the relationship between PAF and COVID-19 is not robust, a healthy diet containing PAF inhibitors may target both inflammation and thrombosis and prevent the deleterious effects of COVID-19. The next step is the experimental confirmation or not of the PAF-COVID-19 hypothesis.

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Section: Omega-3 Fatty Acidsmentioning

confidence: 79%

Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism

2021

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“…These results could explain that fish consumption, although reasonable in terms of a usual diet, is not capable of provoking significant changes. Previous studies regarding the association of RBC fatty acids and PAF enzymes in healthy subjects did not observe any relation between ω-3 fatty acids and the enzymes [ 29 , 44 ].…”

Section: Discussionmentioning

confidence: 90%

“…These findings may explain the increase of the PAF-CPT activity since the decrease of AA could lead to the reduction of PAF production by the remodeling pathway and subsequently to the enhanced production of PAF through the de novo biosynthesis by the activation of PAF-CPT. Fragopoulou et al also reported that a dietary pattern low in ω-6 fatty acids was inversely related with PAF-CPT in healthy subjects [ 29 ]. Furthermore, the negative correlation between ω-3 fatty acids EPA and DHA as well as PAF-CPT only in the CF group may suggest that the ω-3 fatty acids consumed during the clinical trial were borderline sufficient for provoking alternations in the enzymatic activities.…”

Section: Discussionmentioning

confidence: 99%

“…The supernatant was aliquoted and stored at −80 °C. In order to collect RBCs, blood was collected in BD Vacutainer™ EDTA Plasma Tubes, and after appropriate washing RBCs were stored at −80 °C in the presence of BHT as previously described [ 29 ].…”

Section: Methodsmentioning

confidence: 99%

“…The analytical procedure has already been published [ 29 ]. Briefly, the RBC samples underwent a hemolysis and lipids were collected in the chloroform phase of a biphasic solution.…”

Section: Methodsmentioning

confidence: 99%

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Consumption of Farmed Fish, Fed with an Olive-Pomace Enriched Diet, and Its Effect on the Inflammatory, Redox, and Platelet-Activating Factor Enzyme Profile of Apparently Healthy Adults: A Double-Blind Randomized Crossover Trial

Petsini

Ntzouvani

Detopoulou

et al. 2022

Foods

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A fish-rich diet has a beneficial effect on cardiovascular health. The platelet activating factor (PAF) is involved in the development of atherosclerosis, and in vitro results support the regulating action of bioactive nutrients on PAF metabolism. The purpose of this study is to examine whether the consumption of farmed fish fed with an olive-pomace enriched diet (EF) affects PAF metabolism and the markers of inflammation and oxidative stress compared to the consumption of conventionally fed farmed fish (CF). Thirty apparently healthy adults completed a randomized double-blind crossover trial, during which they consumed both CF and EF twice a week for 8 weeks with a six-week washout period in between. The activities of PAF acetylhydrolase (PAF-AH), lysoPAF acetyltransferase (lysoPAF-AT), DTT-insensitive CDP-choline: 1-alkyl-2-acetyl-sn-glycerol-choline-phosphotransferase (PAF-CPT) in leukocytes, and lipoprotein-associated phospholipase A2 (LpPLA2) in serum were determined. The quantities of interleukin-6 (IL-6), high sensitivity C-reactive protein (hsCRP), oxidized LDL (ox-LDL), thiobarbituric acid-reactive substances (TBARS), and glutathione peroxidase (GPx), as well as the serum oxidation, were also determined. Both types of fish exerted similar effects as there were no statistically significant differences between the two interventions except for an elevated PAF-CPT and reduced arachidonic acid (AA) in the red blood cell (RBC) membrane lipids after the EF intake.

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Healthy eating index (HEI) as the predictor of asthma: Findings from NHANES

Lin

et al. 2023

Clinical Nutrition ESPEN

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Associations between red blood cells fatty acids, desaturases indices and metabolism of platelet activating factor in healthy volunteers

Cited by 18 publications

References 49 publications

Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism

Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism

Consumption of Farmed Fish, Fed with an Olive-Pomace Enriched Diet, and Its Effect on the Inflammatory, Redox, and Platelet-Activating Factor Enzyme Profile of Apparently Healthy Adults: A Double-Blind Randomized Crossover Trial

Healthy eating index (HEI) as the predictor of asthma: Findings from NHANES

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