Uso de mioinositol más Bifidobacterium lactis y Lactobacillus rhamnosus para la prevención de diabetes mellitus gestacional en mujeres mexicanas

Reyes-Muñoz, Enrique; Sosa, Salvador Espino Y; Flores-Robles, Claudia Montserrat; Arce-Sánchez, Lidia; Martínez-Cruz, Nayeli; Garduño-García, Guillermo; Tawney-Serrano, Cesar R; Domínguez-Rodríguez, Juan J; Martínez-Hernández, María L; Pérez-Mota, Lilia R; Llanes-Carrillo, Lourdes C; González-Rodríguez, Marcelo

doi:10.24875/gmm.m20000438

Cited by 5 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We did not have a control group without intensive MNT intervention to evaluate the benefit of intensive MNT alone. However, in a study that included participants in our institution with three or more risk factors for GDM without intensive MNT, the incidence of GDM using the IADPSG diagnostic criteria was 46.9% [ 29 ], which was higher than the incidence of GDM in this study and could be attributable to the early intervention in the present study.…”

Section: Discussioncontrasting

confidence: 65%

Intensive Medical Nutrition Therapy Alone or with Added Metformin to Prevent Gestational Diabetes Mellitus among High-Risk Mexican Women: A Randomized Clinical Trial

et al. 2021

Self Cite

View full text Add to dashboard Cite

The aim of this study was to examine the efficacy of intensive medical nutrition therapy (MNT) plus metformin in preventing gestational diabetes mellitus (GDM) among high-risk Mexican women. An open-label randomized clinical trial was conducted. Inclusion criteria were pregnant women with three or more GDM risk factors: Latino ethnic group, maternal age >35 years, body mass index >25 kg/m2, insulin resistance, and a history of previous GDM, prediabetes, a macrosomic neonate, polycystic ovarian syndrome, or a first-degree relative with type 2 diabetes. Women before 15 weeks of gestation were assigned to group 1 (n = 45): intensive MNT-plus metformin (850 mg twice/day) or group 2 (n = 45): intensive MNT without metformin. Intensive MNT included individual dietary counseling, with ≤50% of total energy from high carbohydrates. The primary outcome was the GDM incidence according to the International Association of Diabetes Pregnancy Study Groups criteria. There were no significant differences in baseline characteristics and adverse perinatal outcomes between the groups. The GDM incidence was n = 11 (24.4%) in the MNT plus metformin group versus n = 7 (15.5%) in the MNT without metformin group: p = 0.42 (RR: 1.57 [95% CI: 0.67–3.68]). There is no benefit in adding metformin to intensive MNT to prevent GDM among high-risk Mexican women. Clinical trials registration: NCT01675310.

show abstract

Section: Discussioncontrasting

confidence: 65%

Intensive Medical Nutrition Therapy Alone or with Added Metformin to Prevent Gestational Diabetes Mellitus among High-Risk Mexican Women: A Randomized Clinical Trial

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Probiotics are live microorganisms that bring health benefits to the host when administered in appropriate amounts [ 36 ]. The role of probiotics in preventing carbohydrate disorders and GDM is not yet fully understood or proved; however, there are several studies that show promising results [ 37 , 38 , 39 , 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…After the intervention, the frequency of GDM in the supplemented group was 29.2% and, in the control group, it was 47.9% (RR: 0.61; p = 0.03). The study concluded that supplementation with myo-inositol and probiotics starting at 12–14 weeks of pregnancy reduced the incidence of GDM in Mexican women [ 39 ]. Although the combination of myo-inositol and probiotics has been shown to be beneficial in preventing GDM, no clear conclusions can be drawn as to whether myo-inositol influences these results.…”

Section: Resultsmentioning

confidence: 99%

“…Despite various studies confirming the efficacy of probiotics in preventing GDM [ 37 , 38 , 39 , 40 , 41 ], it still cannot be unanimously stated that this is actually an effective intervention. Some of the available studies agree with the hypothesis that probiotics effectively prevent carbohydrate metabolism disorders in pregnant women [ 45 , 46 , 47 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Probiotics in the Prevention and Treatment of Gestational Diabetes Mellitus (GDM): A Review

et al. 2022

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM)is one of the most common perinatal pathologies, with a prevalence of 5–20% depending on the population or diagnostic standards. It is diagnosed when glucose intolerance is first detected during pregnancy. In the pathogenesis of GDM, genetic, environmental, and pregnancy-related factors (excessive fat storage and increased adipokine and cytokine secretion) play important roles. A growing amount of scientific data has indicated the role of gut microbiota (GM) dysbiosis in the development of glucose intolerance during pregnancy. Previous studies have indicated that, in comparison to healthy pregnant women, GDM individuals have a greater abundance of bacteria belonging to the genera Ruminococcus, Eubacterium, and Prevotella and a lower number of bacteria belonging to the genera Bacteroides, Parabacteroides, Roseburia, Dialister, and Akkermansia. Recently, many studies have focused on treating GDM with methods targeting GM. Several previous studies have analyzed the effect of probiotics on the course of GDM, but their data are inconclusive. In view of this state, the aim of the study was to collect and comprehensively discuss current knowledge regarding the role of probiotic supplementation in preventing and treating GDM. According to the analyzed data, probiotics have a positive influence on glycemic control and are a promising tool for lowering the frequency of GDM. However, further studies must be conducted to determine the optimal model of probiotic therapy (strain, dose, time of intervention, etc.) in pregnant women with GDM.

show abstract

“…También se obtienen metabolitos de las bacterias, especialmente los ácidos grasos de cadena corta los que pueden actuar directa o indirectamente en las células intestinales (mediante la modificación del pH), regulando varios procesos como la carcinogénesis colorrectal, la absorción de minerales, y la eliminación de otras sustancias dañina al organismo humano. (Reyes-Muñoz, Sosa, Flores-Robles, Arce-Sánchez, Martínez-Cruz, & Gutiérrez-Castrellón, 2020), (Reyes-Muñoz, Sosa, Flores-Robles, Arce-Sánchez, Martínez-Cruz,Garduño-García, et al, 2020)…”

unclassified

Microbiota intestinal y obesidad

2021

View full text Add to dashboard Cite

La obesidad está definida como un aumento de la grasa corporal en proporción a la altura del paciente. El diagnóstico se establece con la medición del Índice de Masa Corporal (IMC); el mismo se calcula dividiendo el peso en kilogramos entre la altura en metros al cuadrado. Investigaciones actuales han evidenciado que existe relación entre el microbiota intestinal y la obesidad. El objetivo del presente trabajo estuvo dirigido a describir tal asociación. Se realizó una investigación documental mediante revisión bibliográfica en las bases de datos Google académico, SciELO, Medline, Dialnet, y PubMed; con las palabras claves: obesidad, inflamación, microbioma intestinal y probióticos. La revisión se realizó en los idiomas inglés, español y portugués. Se utilizó bibliografía de los últimos 5 años. Se ha identificado a través de diferentes estudios que en las personas con exceso de peso existen modificaciones en la composición de su flora intestinal, disminuyendo considerablemente las cantidades de bifidobacterias y lactobacilos, a la vez que se incrementan otros gérmenes fundamentalmente bacterias gran negativas que tienen en sus membranas como componente mayoritario lipopolisacáridos que puede estimular la inflamación. A estos gérmenes también se les atribuye la propiedad de hacer más rentable la energía de los alimentos, por lo que son capaces de obtener más energía de la misma ingesta calórica diaria. Las investigaciones actuales muestran que existe relación entre la obesidad y la característica del microbiota intestinal, destacando que en los pacientes obesos existe un incremento de bacteroidetes y menor proporción de gérmenes firmicutes

show abstract

Uso de mioinositol más Bifidobacterium lactis y Lactobacillus rhamnosus para la prevención de diabetes mellitus gestacional en mujeres mexicanas

Cited by 5 publications

References 19 publications

Intensive Medical Nutrition Therapy Alone or with Added Metformin to Prevent Gestational Diabetes Mellitus among High-Risk Mexican Women: A Randomized Clinical Trial

Intensive Medical Nutrition Therapy Alone or with Added Metformin to Prevent Gestational Diabetes Mellitus among High-Risk Mexican Women: A Randomized Clinical Trial

Probiotics in the Prevention and Treatment of Gestational Diabetes Mellitus (GDM): A Review

Microbiota intestinal y obesidad

Contact Info

Product

Resources

About