Cytotoxicity and DNA interaction in a series of aryl terminated iminopyridine Pt(II) complexes

Bondi, Riccardo; Via, Lisa Dalla; Hyeraci, Mariafrancesca; Pagot, Gioele; Labella, Luca; Marchetti, Fabio; Samaritani, Simona

doi:10.1016/j.jinorgbio.2020.111335

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…In the In cells incubated with 1, a remarkable Pt content was found, notably higher with respect to that of the reference drug, suggesting for the new complex the ability to easily cross the plasma cell membrane. It can be hypothesized that such capacity comes from the high lipophilicity of the new complex, a property that could also explain the significant difference with respect to the uptake of cisplatin in both cell lines [20,21,41]. It is worth noting that for cisplatin accumulation in cancer cells, multiple carrier proteins have been proposed [13,42].…”

Section: Mitochondria Damage and Cell Deathmentioning

confidence: 99%

trans-Dichloro(triphenylarsino)(N,N-dialkylamino)platinum(II) Complexes: In Search of New Scaffolds to Circumvent Cisplatin Resistance

et al. 2022

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The high incidence of the resistance phenomenon represents one of the most important limitations to the clinical usefulness of cisplatin as an anticancer drug. Notwithstanding the considerable efforts to solve this problem, the circumvention of cisplatin resistance remains a challenge in the treatment of cancer. In this work, the synthesis and characterization of two trans-dichloro(triphenylarsino)(N,N-dialkylamino)platinum(II) complexes (1 and 2) were described. The trypan blue exclusion assay demonstrated an interesting antiproliferative effect for complex 1 in ovarian carcinoma-resistant cells, A2780cis. Quantitative analysis performed by ICP-AES demonstrated a scarce ability to platinate DNA, and a significant intracellular accumulation. The investigation of the mechanism of action highlighted the ability of 1 to inhibit the relaxation of supercoiled plasmid DNA mediated by topoisomerase II and to stabilize the cleavable complex. Cytofluorimetric analyses indicated the activation of the apoptotic pathway and the mitochondrial membrane depolarization. Therefore, topoisomerase II and mitochondria could represent possible intracellular targets. The biological properties of 1 and 2 were compared to those of the related trans-dichloro(triphenylphosphino)(N,N-dialkylamino)platinum(II) complexes in order to draw structure–activity relationships useful to face the resistance phenotype.

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Section: Mitochondria Damage and Cell Deathmentioning

confidence: 99%

trans-Dichloro(triphenylarsino)(N,N-dialkylamino)platinum(II) Complexes: In Search of New Scaffolds to Circumvent Cisplatin Resistance

et al. 2022

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“…In recent years, we focused on the synthesis and biological studies of many platinumbased complexes endowed with antiproliferative properties [34][35][36][37][38][39][40][41][42]. Such investigations allowed us to conclude that the presence of a triphenylphosphine ligand can promote cell uptake and, in many cases, provide modes of action against cisplatin-resistant cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Dibromo- and Dichlorotriphenylphosphino N-Acyclic Carbene Complexes of Platinum(II)—Synthesis and Cytotoxicity

Farasat,

Labella,

Di Paolo

et al. 2023

Inorganics

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Some new dichloro- and dibromotriphenylphosphino isonitrile and N-acyclic (NAC) carbene complexes of platinum(II) were synthesized, starting from suitable dinuclear precursors. The reaction of cyclohexylisonitrile with trans-[Pt(μ-X)X(PPh3)]2, followed by the addition of N,N-diethylamine afforded the corresponding N-acyclic carbene (NAC)derivatives cis-[PtX2(PPh3)(NAC)] in 61–64% isolated yield. The cis geometry was attributed based on the comparison with known structures. The stability of the complexes in pure DMSO, DMSO/H2O, and DMSO/NaClaq mixtures was evaluated. While pure DMSO, as well as DMSO/H2O, did not affect the nature of either dichloro- or dibromo-compounds, dibromo derivatives were not stable in the presence of chloride ions. Since a high concentration of chloride ions is essential to perform in vitro cell assays, only dichlorocomplexes were tested as cytotoxic agents against HepG2 and human tumor cells. Among the tested complexes, NAC derivatives showed a moderate effect on MSTO-211H.

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Heterobimetallic platinum(ii) complexes with increased cytotoxicity against ovarian cancer cell lines

et al. 2021

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Cytotoxicity and DNA interaction in a series of aryl terminated iminopyridine Pt(II) complexes

Cited by 3 publications

References 47 publications

trans-Dichloro(triphenylarsino)(N,N-dialkylamino)platinum(II) Complexes: In Search of New Scaffolds to Circumvent Cisplatin Resistance

trans-Dichloro(triphenylarsino)(N,N-dialkylamino)platinum(II) Complexes: In Search of New Scaffolds to Circumvent Cisplatin Resistance

Dibromo- and Dichlorotriphenylphosphino N-Acyclic Carbene Complexes of Platinum(II)—Synthesis and Cytotoxicity

Heterobimetallic platinum(ii) complexes with increased cytotoxicity against ovarian cancer cell lines

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