Role of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in Peyronie's disease

Abstract

Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been associated with multiple entities and several types of cancers. They can be assumed as markers of inflammatory imbalance. The objective of this study is to evaluate the NLR and PLR in Peyronie's disease (PD) and to establish a comparison of its values in the acute and chronic stages. We recruited patients with PD from March 2018 to March 2019. The patients enrolled underwent medical and sexual history as well as a physical examination. The values of blood count of each patient were collected both in the acute and chronic stages. Wilcoxon test was used to compare the acute and chronic stage ratios. Kruskal–Wallis test was carried out to evaluate the impact of treatments on the ratios. To identify cutoff values, we used sensibility and specificity tables and receiver operating characteristic (ROC) curves. A total of 120 patients were enrolled. Their mean age was 55.85 (range: 18–77) years and the mean penile curvature was 48.43° (range: 10°–100°). In the acute stage, the mean NLR was 2.35 and the mean PLR was 111.22. These ratios, in the chronic stage, were 1.57 and 100.00, respectively. Statistically significant differences between acute and stable stages for both indices were found (NLR: P < 0.0001; PLR: P = 0.0202). The optimal cutoff for classification in acute or stable stage was 2 for NLR and 102 for PLR. According to our results, with an ordinary blood count, we could have important indications regarding the disease stage of the patient, and consequently on the most appropriate type of therapy to choose.

Which inflammatory marker, between systemic immune-inflammation index and neutrophil to eosinophil ratio, is associated with Peyronie’s disease and are there any implications for a better understanding of its mechanisms?

“…Analogously, Garcia Rojo et al, more recently, evaluated the role of NLR and PLR in PD in relation to acute and chronic phases of PD, reporting a statistically significant difference for both ratios in discriminating the phase of the disease. Differently from the previously reported studies [34] the aim of our work was to evaluate the role of inflammatory biomarkers in PD patients versus no PD controls, using patients with stable PD. Currently, no specific blood tests are available for the diagnosis of PD.…”

Diagnostic signiffcance of the lymphocyte-monocyte index in Dupuytren's contracture

“…Вероятно, нейтрофилы не имеют значимой роли в патогенезе ладонного фасциального фиброматоза, хотя при детальном иммуногистохимическом исследовании обнаруживались немногочисленные зрелые гранулоциты вблизи кровеносных сосудов и в пролиферирующих фиброматозных узлах [14]. При эктопическом фиброматозе -болезни Пейрони -нейтрофильно-лимфоцитарный индекс оценен как важный показатель, уточняющий стадию заболевания и тактику лечения [31,32], однако не все исследовательские группы пришли к такого рода выводам [33].…”

“…При обследовании 21 пациента с КД установлена корреляция содержания T-и B-лимфоцитов периферической крови с тяжестью заболевания [18]. При эктопическом фасциальном фиброматозе -болезни Пейрони -выявлена взаимосвязь значений нейтрофильно-лимфоцитарного индекса периферической крови с острой или стабильной стадией заболевания [19]. Однако в доступной литературе мы не встретили данных о возможных изменениях соотношений нейтрофилов, лимфоцитов и моноцитов периферической крови при КД.…”

Voice Assistants as Consultants for Male Patients with Sexual Dysfunction: A Reliable Option?

“…ED [14][15][16][17][18][19][20], PE [21], PD [22][23][24][25][26][27][28][29][30], male infertility [31,32], genital aesthetic concerns [33][34][35][36][37], as well as several other conditions [38][39][40][41][42][43][44][45] can significantly impact the sexual health of male patients. When this happens, worries and doubts often lead patients to independently search for information on the Internet with every available tool [1,2].…”