Lichenoid dermatoses with pseudomelanocytic nests vs inflamed melanoma in situ: A comparative study

Panse, Gauri; McNiff, Jennifer M.

doi:10.1111/cup.13945

Cited by 10 publications

(27 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the occuerence of pseudomelanocytic nests, known as aggregates of Melan-A positive cells at the dermoepidermal junction, may represent a diagnostic challenge in melanoma in situ associated with lichenoid inflammation. Clinical data, which are crucial in these cases, are not always available to pathologists; therefore, the concomitant use of nuclear stainings such as MITF (microphthalmia-associated transcription factor) and SOX10 has been proposed [ 49 ]. SOX10 exhibited higher specificity (96%) compared to Melan-A (17%) in evaluating epidermal malnocytes and consequently in avoiding overdiagnosis of melanoma in situ in sun-damaged skin [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

The Importance of Immunohistochemistry in the Evaluation of Tumor Depth of Primary Cutaneous Melanoma

et al. 2023

View full text Add to dashboard Cite

Primary cutaneous melanoma (PCM) is the most aggressive skin malignancy, with an increasing incidence and significant mortality. Tumoral invasion, expressed as Breslow thickness, is routinely assessed on hematoxylin and eosin (HE), although this stain may sometimes underestimate the tumoral depth. The aim of this study was to compare the efficiency of the immunohistochemical (IHC) markers S-100, SOX10, Melan-A, and HMB-45 with HE for the evaluation of the Breslow thickness and staging of PCM. This retrospective study included 46 cases of PCM diagnosed between 2015 and 2022; for each case, the Breslow thickness using HE, S-100, SOX10, Melan-A, and HMB-45 was measured and the appropriate T category was recorded. The highest values of the Breslow thickness were observed for S-100. However, S-100, SOX10, and Melan-A provided statistically significant higher values of the Breslow thickness compared to HE, but no difference was noted between HMB-45 and HE. S-100 was most frequently involved in increasing the T category (26.1%), the majority of cases being upstaged from T1a to T1b. The IHC markers S-100, SOX10, and Melan-A contributed to better evaluation of the melanoma invasion, especially in thin melanomas, but their impact on staging and consecutive treatment remains to be confirmed by future studies.

show abstract

Section: Discussionmentioning

confidence: 99%

The Importance of Immunohistochemistry in the Evaluation of Tumor Depth of Primary Cutaneous Melanoma

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Presence of diffuse lichenoid inflammation is a well-known confounding factor in cases suspicious for a hidden melanocytic lesion. 6,7 Case reports have attempted to assess the utility of Melan A/Mart-1 as a single diagnostic immunostain in a BLK. Many ultimately performed additional stains such as HMB45, S100, and MITF to definitively rule out a melanocytic lesion and make a correct diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Presence of diffuse lichenoid inflammation is a well‐known confounding factor in cases suspicious for a hidden melanocytic lesion 6,7 . Case reports have attempted to assess the utility of Melan A/Mart‐1 as a single diagnostic immunostain in a BLK.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic utility of SOX10 immunostaining in benign lichenoid keratosis: A study of 21 cases

et al. 2022

View full text Add to dashboard Cite

Background Benign lichenoid keratosis (BLK) is a cutaneous lesion that can clinically mimic malignancy and may represent regression of a pre‐existing lesion. BLK may show epidermal pseudo‐nests prompting evaluation for a melanocytic lesion. False positivity of MART‐1/Melan‐A immunostaining in pseudonests has been showed; however, the value of SRY‐related HMG‐box 10 (SOX10) staining in BLK with features suspicious for a melanocytic proliferation has not been previously reported. Methods Twenty‐one cases of BLK from 2015 to 2020 were identified. Slides were reviewed and SOX10 immunohistochemistry was performed on each case. Subsequently, Melan‐A immunohistochemical staining was performed on all cases. Results In 10 cases (47.6%), unexpected SOX10 staining was seen in rare to numerous small, single cells in the epidermis above the basal cell layer. No malignancy was identified. Of the 10 cases, 8 (80%) showed suprabasal SOX10 staining did not show similar suprabasal Melan‐A staining; 2 (20%) cases showed scattered suprabasal cells positive for Melan‐A. Conclusion SOX10 immunostaining in BLK can highlight scattered cells in the epidermis (not easily noticeable on routine stain). Performing SOX10 immunostain alone on BLK can prompt a misdiagnosis of a melanocytic lesion and should be done with caution.

show abstract

“…Percentage fraction of cases of lichenoid dermatoses with “pseudomelanocytic nests” positive in immunohistochemical staining of HMB‐45, S‐100, Melan‐A/Mart‐1, MITF, and SOX‐10. The analysis was based on 12 papers in which 1–10 cases were examined 21,56,58–60,62–68 . In total 33 lesions were investigated.…”

Section: Lichenoid Dermatoses Mimicking Melanoma In Situmentioning

confidence: 99%

The detectability of intraepidermal melanocytes—A narrative review of immunohistochemical studies

Kuźbicki

Brożyna

2022

J Cutan Pathol

View full text Add to dashboard Cite

Some intraepidermal lesions, even the nonmelanocytic ones, may mimic melanoma in situ. The cytoplasmic clarity in atypical basal cells, architectural disorder with cell aggregates or nest-like structures within the epidermis often cause challenge particularly in sun-damaged skin. The aim of this review is to evaluate the effectiveness of the most often used immunohistochemical melanocyte markers in the diagnosis of intraepidermal lesions. All the analyzed markers can be useful in detection of intraepidermal melanocytes that occur more densely in lentigo maligna than in solar lentigo or sun-damaged skin. However, the number of these cells is underestimated by HMB-45 and Mel-5. The cytoplasmic Melan-A staining may overestimate melanocyte number and highlight the dendritic process. Atypical melanized keratinocytes in actinic keratoses and nest-like structures in lichenoid dermatoses may mimic atypical melanocytes in melanomas in situ. S-100 remains a marker of high sensitivity but low specificity. The nuclear localization of MITF, SOX-10, and PRAME overcomes the problem of melanosome transfer to cells of other types. Neither MITF nor SOX-10 is detectable in keratinocytes, which makes them useful in distinguishing actinic keratoses from melanomas in situ. The use of markers considered as melanocyte specific suggests that lichenoid dermatoses constitute a heterogeneous group of lesions.

show abstract

Lichenoid dermatoses with pseudomelanocytic nests vs inflamed melanoma in situ: A comparative study

Cited by 10 publications

References 16 publications

The Importance of Immunohistochemistry in the Evaluation of Tumor Depth of Primary Cutaneous Melanoma

The Importance of Immunohistochemistry in the Evaluation of Tumor Depth of Primary Cutaneous Melanoma

Diagnostic utility of SOX10 immunostaining in benign lichenoid keratosis: A study of 21 cases

The detectability of intraepidermal melanocytes—A narrative review of immunohistochemical studies

Contact Info

Product

Resources

About