Emerging roles of steroid receptor coactivators in stromal cell responses

Rohira, Aarti D.; Lonard, David M.; O’Malley, Bert W.

doi:10.1530/joe-20-0511

Cited by 6 publications

(2 citation statements)

References 48 publications

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“…SRCs contribute to angiogenesis, cell differentiation and inflammation, beyond the conventional epithelial cell compartments by regulating stromal cell components (reviewed in Ref. [27]).…”

Section: Cointegrators Govern the Acetylation Status Of Nuclear Recep...mentioning

confidence: 99%

Acetylation of nuclear receptors in health and disease: an update

et al. 2022

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Lysine acetylation is a common reversible post‐translational modification of proteins that plays a key role in regulating gene expression. Nuclear receptors (NRs) include ligand‐inducible transcription factors and orphan receptors for which the ligand is undetermined, which together regulate the expression of genes involved in development, metabolism, homeostasis, reproduction and human diseases including cancer. Since the original finding that the ERα, AR and HNF4 are acetylated, we now understand that the vast majority of NRs are acetylated and that this modification has profound effects on NR function. Acetylation sites are often conserved and involve both ordered and disordered regions of NRs. The acetylated residues function as part of an intramolecular signalling platform intersecting phosphorylation, methylation and other modifications. Acetylation of NR has been shown to impact recruitment into chromatin, co‐repressor and coactivator complex formation, sensitivity and specificity of regulation by ligand and ligand antagonists, DNA binding, subcellular distribution and transcriptional activity. A growing body of evidence in mice indicates a vital role for NR acetylation in metabolism. Additionally, mutations of the NR acetylation site occur in human disease. This review focuses on the role of NR acetylation in coordinating signalling in normal physiology and disease.

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“…SRCs contribute to angiogenesis, cell differentiation and inflammation, beyond the conventional epithelial cell compartments by regulating stromal cell components (reviewed in Ref. [27]).…”

Section: Cointegrators Govern the Acetylation Status Of Nuclear Recep...mentioning

confidence: 99%

Acetylation of nuclear receptors in health and disease: an update

et al. 2022

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“…The stroma consists of fibroblasts, immune cells, endothelial cells, pericytes, neurons and these are considered as the key cell types. Nevertheless, the stroma may also contain other cell types, like adipocytes and mesenchymal stromal cells, depending on the tissue (1). The many facets of the distinct stromal cell populations are only now starting to be acknowledged since the stromal cells in the various tissues have significantly different morphologies and functional features (2).…”

Section: Introductionmentioning

confidence: 99%

Stromal Hücrelerin Tarihçesi: İnterstisyel Cajal Hücrelerinden Telositlere - İnsan Telositlerine ve Olası İşlevlerine Kısa Bir Bakış

PURELKU,

TANRIVERDİ

2023

Ege Tıp Dergisi

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In the organ microenvironment stromal cells make up an essential population, however research on them has been very limited. The stroma mainly consists of fibroblasts that reside together with mesenchymal cells, endothelial cells, pericytes, neurons, adipocytes, immune cells etc. The different morphologies and functional properties of stromal cells have led to subclassification of different cell types in connective tissue. Among them are the interstitial cells of Cajal and telocytes. Telocytes are one of the newer cells known for their small cell bodies and long telopods and have been recently identified in the connective tissue of many organs. Telocytes are strategically positioned near nerve endings, around blood capillaries and in close relation with particular cells. The network of telocytes is engaged in integrating information from multiple sources and coordinating the tissue homeostasis in response to the tissues local functional requirements. Extracellular vesicles provide a means of bidirectional communication, and their secretome appears to control the mechanisms of stem cell differentiation. Telocytes have been identified in various organs, specifically in human heart, lungs, brain, eye, thyroid, skeletal muscles, skin, salivary glands, gastrointestinal tract, pancreas, gallbladder, liver, and organs of the male and female urogenital system. Additionally, given the heterogeneity of the organs in which telocytes are found, and their capability to play a role in the etiopathogenesis of various diseases, the concept of "telocytopathies" has emerged. In conclusion, telocytes are increasingly becoming a focal point for the understanding of idiopathic diseases that affect humans as well as the development of new diagnostic and therapeutic approaches, and they have the potential to contribute to regenerative medicine.

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Steroid hormones: chemistry, biosynthesis, and metabolism

Litwack

2022

Hormones

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Emerging roles of steroid receptor coactivators in stromal cell responses

Cited by 6 publications

References 48 publications

Acetylation of nuclear receptors in health and disease: an update

Acetylation of nuclear receptors in health and disease: an update

Stromal Hücrelerin Tarihçesi: İnterstisyel Cajal Hücrelerinden Telositlere - İnsan Telositlerine ve Olası İşlevlerine Kısa Bir Bakış

Steroid hormones: chemistry, biosynthesis, and metabolism

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