Clinicopathological, Molecular Features and Prognosis of Colorectal Cancer with Mucinous Component

Abstract

Background: Colorectal cancer (CRC) with mucinous component is associated with distinct characteristics and controversial prognosis. Patients & methods: A total of 1800 CRC patients were retrospectively enrolled and grouped by the mucinous content of the primary tumors. The clinicopathological characteristics and overall survival rate were compared between groups. Results: Mucinous adenocarcinoma (MAC) and adenocarcinoma with mucinous component (AMC) had higher frequencies of DNA mismatch repair protein deficiency, KRAS, BRAF and PIK3CA mutations as compared to those of conventional adenocarcinoma (CAC). MAC had worse prognosis than CAC. However, MAC was not an independent prognostic factor in multivariable analysis. Conclusion: Molecular features of AMC and MAC were similar, which were different from those of CAC. Neither MAC nor AMC were independent prognostic factors for CRC.

Lymphocyte antigen 6G6D-mediated modulation through p38α MAPK and DNA methylation in colorectal cancer

“…S2B). Mucinous dedifferentiation was associated with the CIMP-H/MSI phenotype, a high frequency of BRAF and KRAS mutations, and fewer changes in the p53 pathway, consistent with the literature [29] (Additional file 1: Fig. S2C, D, S3A).…”

“…All cases were also analyzed for mismatch repair protein expression by IHC. More than 50% of mucinous tumors were MMR-deficient, compared to 15% of classical adenocarcinomas, which is consistent with the literature [29]. Next, we examined the tumor microenvironment for infiltration of LY6G6D + cells in mucinous and non-mucinous tumors.…”

“…S1D). Mucinous CRC is a specific histological subtype commonly associated with the proximal colon and characterized by dedifferentiation and mucin production [29]. Because LY6G6D has not previously been associated with differences in histotype, we analyzed the global gene expression profiles of mucinous and classical adenocarcinomas in the COAD and READ TCGA databases.…”

Value of the log odds of positive lymph nodes for prognostic assessment of colon mucinous adenocarcinoma: Analysis and external validation

“…Indeed, the effect of MAC on the survival of colon MAC patients remains debatable. Several studies have demonstrated that the MAC subtype was associated with a worse prognosis 6,9–11,24–26 . In a population‐based survival study, MAC had a poor outcome because of advanced disease 27 .…”

“…Several studies have demonstrated that the MAC subtype was associated with a worse prognosis. 6,[9][10][11][24][25][26] In a population-based survival study, MAC had a poor outcome because of advanced disease. 27 This association has been confirmed in a large metaanalysis.…”