Evaluating efficacy of a novel dentifrice in reducing probing depths in Stage I and II periodontitis maintenance patients: A randomized, double‐blind, positive controlled clinical trial

Abstract

Background: Compliance to periodontal maintenance therapy (PMT) is essential for long-term periodontal health. Between PMT visits, patients must maintain good oral hygiene. A dentifrice with demonstrable clinical benefits for use between PMT visits would be highly desirable. The aim of this clinical study was to investigate the effect of a novel dental gel on probing depths (PD) and inflammation when used as a home care dentifrice in Stage I and II periodontitis patients.Methods: This double-blind clinical study randomized 65 subjects with Stage I and II periodontitis to the novel dental gel containing 2.6% EDTA, and a commercially available anti-gingivitis dentifrice with 0.454% stannous fluoride. Primary endpoint was PD at 6 months for those sites with baseline PD ≥ 4 mm and secondary endpoints included whole mouth mean scores of modified gingival index (MGI), modified sulcus bleeding index (mSBI) and plaque index (PI). No SRP was performed at baseline. Results: Subjects using the novel dentifrice showed significant PD reductions of 1.18 mm (from 4.27 mm at baseline to 3.09 mm at 6 months) compared to 0.93 mm (from 4.23 mm at baseline to 3.30 mm at 6 months) shown for those using the positive control dentifrice. Difference between treatments at 6 months was 0.21 mm with P-value = 0.0126. Significant improvements in MGI (P = 0.0000), mSBI (P = 0.0000), and PI (P = 0.0102) were also observed in 6 months. Conclusion:The novel dentifrice showed significant reductions in PD and gingival inflammation over 6 months solely as a home care dentifrice without baseline SRP in Stage I and II periodontitis maintenance patients.

Better living through chemistry? A randomized, double‐blind controlled study evaluating the efficacy of plaque control and gingival health impacts of a novel stannous fluoride‐containing gel

“…Previous studies have evaluated the use of a novel dental gel containing 2.6% EDTA without the addition of fluoride in patients with gingivitis and periodontitis 22–27,31 . Studies evaluating the effects of this dentifrice have demonstrated increased effectiveness of plaque removal, improved gingival health, and diminution of plaque repopulation in patients with gingivitis 22,31 .…”

“…Limitations to existing antiplaque therapies include reported taste alteration, tooth structure staining, dental abrasion, dentinal sensitivity, and reactive gingival lesions 21 . Previous studies have demonstrated the efficacy of a dental gel with 2.6% ethylenediamine tetra‐acetic acid (EDTA) as an antitartar agent in reducing oral plaque deposit, gingival inflammation, and probing depths with minimal patient‐reported side effects or impact upon tooth surface microarchitecture and microhardness 22–27 . These previous investigations of 2.6% EDTA containing dentifrice lacked the inclusion of fluoride in the formulation.…”

Ação de dentifrícios antiplaca e anticálculo sobre esmalte dentário bovino

“…O efeito dos dentifrícios antiplaca e anticálculo sobre a massa e a rugosidade do esmalte dentário, bovino ou humano, é um assunto pouco investigado e descrito na literatura. Os estudos, de modo geral, avaliam o efeito antimicrobiano dos dentifrícios antiplaca 6,21,22 , ou a ação dos dentifrícios anticálculo na inibição e no controle do cálculo dental 23 e doenças periodontais 8 .…”

“…Dentifrícios e antissépticos com diferentes composições e substâncias terapêuticas têm sido disponibilizados aos consumidores, com o objetivo de promover a redução e o controle de micro-organismos existentes na cavidade oral 6 . A função dos dentifrícios antiplaca e anticálculo é prevenir a formação do biofilme e, consequenemente, as doenças periodontais 7 , que podem agravar doenças sistêmicas, como diabetes mellitus, doenças cardiovasculares e artrite reumatoide 8 .…”

New US toothpaste significantly improves gum health

“…Researchers at the UCI Beckman Laser Institute & Medical Clinic recently reported results of a six-month long study, showing for the first time that a novel toothpaste demonstrated medically significant improvements in the health of the gums of patients with periodontitis, the most severe form of gum disease. 1 As a part of her focus on translational research, Dr Petra Wilder Smith initiated a double-blinded study testing a novel dental gel, LivFresh Dental Gel, against an FDA-approved anti-gingivitis toothpaste, to investigate their effects on gum health in patients with early to moderate periodontitis. The six-month long study compared how the two toothpastes affected periodontal pocket depths, gingival inflammation, and gum bleeding in patients with periodontitis who were in maintenance care.…”