Biological activity and antimicrobial property of Cu/a-C:H nanocomposites and nanolayered coatings on titanium substrates

Thukkaram, Monica; Vaidulych, Mykhailo; Kylián, Ondřej; Rigole, Petra; Aliakbarshirazi, Sheida; Asadian, Mahtab; Nikiforov, Anton; Biederman, Hynek; Coenye, Tom; Laing, Gijs Du; Morent, Rino; Tongel, Alexander Van; Wilde, Lieven De; Verbeken, Kim

doi:10.1016/j.msec.2020.111513

Cited by 22 publications

(8 citation statements)

References 46 publications

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“…CuO NPs offer advantages over Ag NPs, including cost-effectiveness, chemical stability and ease of combining with polymers, which makes them an attractive choice for biomaterial applications [140]. Further, Cu NPs have antibacterial, osteogenic and angiogenic properties [141], and have been applied towards the enhancement of both the bioactivity and the antimicrobial properties of Ti dental implants [142]. More recently, van Hengel et al incorporated varying amounts of Ag and Cu NPs into TiO 2 coating on additively manufactured Ti-6Al-4V porous implants via plasma electrolytic oxidation [143].…”

Section: Coppermentioning

confidence: 99%

Dental Implant Nano-Engineering: Advances, Limitations and Future Directions

Zhang

Gulati

et al. 2021

Nanomaterials

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Titanium (Ti) and its alloys offer favorable biocompatibility, mechanical properties and corrosion resistance, which makes them an ideal material choice for dental implants. However, the long-term success of Ti-based dental implants may be challenged due to implant-related infections and inadequate osseointegration. With the development of nanotechnology, nanoscale modifications and the application of nanomaterials have become key areas of focus for research on dental implants. Surface modifications and the use of various coatings, as well as the development of the controlled release of antibiotics or proteins, have improved the osseointegration and soft-tissue integration of dental implants, as well as their antibacterial and immunomodulatory functions. This review introduces recent nano-engineering technologies and materials used in topographical modifications and surface coatings of Ti-based dental implants. These advances are discussed and detailed, including an evaluation of the evidence of their biocompatibility, toxicity, antimicrobial activities and in-vivo performances. The comparison between these attempts at nano-engineering reveals that there are still research gaps that must be addressed towards their clinical translation. For instance, customized three-dimensional printing technology and stimuli-responsive, multi-functional and time-programmable implant surfaces holds great promise to advance this field. Furthermore, long-term in vivo studies under physiological conditions are required to ensure the clinical application of nanomaterial-modified dental implants.

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Section: Coppermentioning

confidence: 99%

Dental Implant Nano-Engineering: Advances, Limitations and Future Directions

Zhang

Gulati

et al. 2021

Nanomaterials

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“…This versatile method enables the production of coatings with a controllable composition resulting in efficient bactericidal and other (optical, electrical, mechanical) properties [14][15][16][17][18] . An alternative for Cu NPs introduction in the a-C films is cluster beam deposition combined with plasmaenhanced chemical vapour deposition 19 .…”

Section: Introductionmentioning

confidence: 99%

“…Metal release studies were not limited to ultra-pure water but included immersion in standard simulated body fluid 29 , artificial seawater 26 , and different pH biological solutions 30,31 . The release of Cu NPs and Cu ions depends on the coating structure 19 , contact time, and amount of the solvent (medium) 32,33 where it can lead to oxidation and fast degradation of metallic Cu resulting in the burst release happening at the first immersion stages. This may affect the antibacterial and antiviral properties and have cytotoxic effect 19 .…”

Section: Introductionmentioning

confidence: 99%

“…The release of Cu NPs and Cu ions depends on the coating structure 19 , contact time, and amount of the solvent (medium) 32,33 where it can lead to oxidation and fast degradation of metallic Cu resulting in the burst release happening at the first immersion stages. This may affect the antibacterial and antiviral properties and have cytotoxic effect 19 . Therefore, researching the coating compositions demonstrating slow and controlled Cu release is of paramount importance 34 .…”

Section: Introductionmentioning

confidence: 99%

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Antiviral and Antibacterial Efficacy of Nanocomposite Amorphous Carbon Films with Copper Nanoparticles

Bakhet,

Tamulevičienė,

Vasiliauskas

et al. 2023

Preprint

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Copper compound-rich films and coatings are effective against widespread viruses and bacteria. Even though the killing mechanisms are still debated it is agreed that the metal ion, nanoparticle release, and surface effects are of paramount importance in the antiviral and antibacterial efficacy of the surfaces. In this work we have investigated the behaviour of the reactive magnetron sputtered nanocomposite diamond-like carbon thin films with copper nanoparticles (DLC:Cu). The films were etched employing oxygen plasma and/or exposed to ultra-pure water aiming to investigate the differences of the Cu release in the medium and changes in film morphology. Pristine films were more effective in the Cu release reaching up to 1.3 mg/L/cm2concentration. Plasma processing resulted in the oxidation of the films which released less Cu but after exposure to water, their average roughness increased more, up to 5.5 nm. Pristine and O2plasma processed DLC:Cu films were effective against both model coronavirus and herpesvirus after 1-hour contact time and reached virus reduction up to 2.23 and 1.63 log10, respectively. Pristine DLC:Cu films were more effective than plasma-processed ones against herpesvirus, while less expressed difference was found for coronavirus. A bactericidal study confirmed that pristine DLC:Cu films were effective against gram-negativeE. coliand gram-positiveE. faecalisbacteria. After 3 hours 100% antibacterial efficiency (ABE) was obtained forE. coliand 99.83% forE. faecalis. After 8 hours and longer exposures, 100% ABE was reached. The half-life inactivation of viruses was 8.10 – 11.08 minutes and forE. faecalis19.5 – 30.2 minutes.

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“…Some are based on complex polymer substances such as parylene-c, poly-dimethyl siloxane, or poly-methyl methacrylate [ 16 ]. Others focus on the use of metal-based coatings such as zinc pyrithione [ 17 , 18 ], zinc oxide [ 19 ], copper [ 20 ], titan dioxide [ 21 , 22 , 23 ], or silver [ 24 , 25 ]. Biocides such as diuoron, and Sea-Nine 211 were also effective [ 17 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Photodynamic Coatings Reduce the Microbial Burden on Environmental Surfaces in Public Transportation—A Field Study in Buses

Kalb

Bäßler

Schneider-Brachert

et al. 2022

IJERPH

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Millions of people use public transportation daily worldwide and frequently touch surfaces, thereby producing a reservoir of microorganisms on surfaces increasing the risk of transmission. Constant occupation makes sufficient cleaning difficult to achieve. Thus, an autonomous, permanent, antimicrobial coating (AMC) could keep down the microbial burden on such surfaces. A photodynamic AMC was applied to frequently touched surfaces in buses. The microbial burden (colony forming units, cfu) was determined weekly and compared to equivalent surfaces in buses without AMC (references). The microbial burden ranged from 0–209 cfu/cm2 on references and from 0–54 cfu/cm2 on AMC. The means were 13.4 ± 29.6 cfu/cm2 on references and 4.5 ± 8.4 cfu/cm2 on AMC (p < 0.001). The difference in microbial burden on AMC and references was almost constant throughout the study. Considering a hygiene benchmark of 5 cfu/cm2, the data yield an absolute risk reduction of 22.6% and a relative risk reduction of 50.7%. In conclusion, photodynamic AMC kept down the microbial burden, reducing the risk of transmission of microorganisms. AMC permanently and autonomously contributes to hygienic conditions on surfaces in public transportation. Photodynamic AMC therefore are suitable for reducing the microbial load and closing hygiene gaps in public transportation.

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Biological activity and antimicrobial property of Cu/a-C:H nanocomposites and nanolayered coatings on titanium substrates

Cited by 22 publications

References 46 publications

Dental Implant Nano-Engineering: Advances, Limitations and Future Directions

Dental Implant Nano-Engineering: Advances, Limitations and Future Directions

Antiviral and Antibacterial Efficacy of Nanocomposite Amorphous Carbon Films with Copper Nanoparticles

Antimicrobial Photodynamic Coatings Reduce the Microbial Burden on Environmental Surfaces in Public Transportation—A Field Study in Buses

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