Disparities in cardio metabolic risk between Black and White women with polycystic ovary syndrome: a systematic review and meta-analysis

Kazemi, Maryam; Kim, Joy Y.; Parry, Stephen; Azziz, Ricardo; Lujan, Marla E.

doi:10.1016/j.ajog.2020.12.019

Cited by 11 publications

(5 citation statements)

References 134 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, studies suggest that delayed sleep cycles may be more harmful among Black/African American mothers compared to White mothers ( Eastman, 2012 , Smith, 2009 ). Typically, later chronotypes have been associated with negative health markers (e.g., elevated cardiometabolic risk ( Baldanzi, 2022 ), which are also more prevalent among Black/African American women of childbearing age ( Kazemi, 2021 , Kalinowski et al, 2019 ). Thus, it is surprising that racial/ethnic differences in chronotype were not identified in our sample.…”

Section: Discussionmentioning

confidence: 99%

Sleep duration and chronotype of pregnant women in the United States: An online cross-sectional survey study

Cassidy¹,

Bailey²,

Napolitano³

et al. 2023

Preventive Medicine Reports

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Sleep duration and chronotype of pregnant women in the United States: An online cross-sectional survey study

Cassidy¹,

Bailey²,

Napolitano³

et al. 2023

Preventive Medicine Reports

View full text Add to dashboard Cite

“…Moreover, it seems that nonobese patients have a higher prevalence of hypertriglyceridemia and low HDL [39]. And there is evidence suggesting that black women with PCOS have lower Tgs than white women, although the risk of cardiometabolic disease is higher [40]. Dyslipidaemia were also reported to affect long-term outcomes of PCOS patients.…”

Section: Dyslipidaemia In Pcosmentioning

confidence: 99%

Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites

Chen

Pang

2021

Metabolites

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among women of reproductive age and is associated with many metabolic manifestations, such as obesity, insulin resistance (IR) and hyperandrogenism. The underlying pathogenesis of these metabolic symptoms has not yet been fully elucidated. With the application of metabolomics techniques, a variety of metabolite changes have been observed in the serum and follicular fluid (FF) of PCOS patients and animal models. Changes in metabolites result from the daily diet and occur during uncommon physiological routines. However, some of these metabolite changes may provide evidence to explain possible mechanisms and new approaches for prevention and therapy. This article reviews the pathogenesis of PCOS metabolic symptoms and the relationship between metabolites and the pathophysiology of PCOS. Furthermore, the potential clinical application of some specific metabolites will be discussed.

show abstract

“…68 We were cautious about including women with a clinically established PCOS diagnosis as recommended by the PCOS Guideline 35 to improve the likelihood of reliable assessment of our clinical population. [57][58][59]63 Unpublished literature was not included.…”

Section: Data Sources and Search Strategymentioning

confidence: 99%

“…51,56 The conflicting reports may stem from small sample sizes of the individual trials, which have limited their statistical power to capture differences in muscle outcomes. Difficulties also exist in establishing an accurate definition of PCOS status owing to a reliance on a self-reported diagnosis that is unreliable likely leading to misdiagnosis, 35,[57][58][59] unreliable measures of androgen status, 60 and/or ovarian morphology. 18,61,62 Variability in defining control cohorts and heterogeneity in groups' ethnic composition 27 may be contributory.…”

Section: Introductionmentioning

confidence: 99%

Obesity, but not hyperandrogenism or insulin resistance, predicts skeletal muscle mass in reproductive‐aged women with polycystic ovary syndrome: A systematic review and meta‐analysis of 45 observational studies

et al. 2021

Self Cite

View full text Add to dashboard Cite

Women with polycystic ovary syndrome (PCOS) exhibit reduced muscle insulinmediated glucose uptake, potentially attributed to altered muscle mass; however, this is inconclusive. Altered muscle mass may aggravate PCOS complications. Our systematic review and meta-analysis evaluated whether PCOS alters muscle mass and function. Databases (MEDLINE, Web of Science, Scopus) were searched through September 2, 2020, for studies documenting skeletal muscle mass (lean tissue mass) and function (strength) in PCOS and control groups. The primary outcome was total lean body mass (LBM) or fat-free mass (FFM). Data were pooled by random-effects models and expressed as mean differences and 95% confidence intervals. Forty-five studies (n = 3676 participants) were eligible. Women with PCOS had increased total (0.83 [0.08,1.58] kg; p = 0.03; I 2 = 72.0%) yet comparable trunk (0.84 [−0.37,2.05] kg; p = 0.15; I 2 = 73.0%) LBM or FFM versus controls. Results of metaregression analyses showed no associations between mean differences between groups in total testosterone or homeostatic model assessment of insulin resistance and total or trunk LBM or FFM (All: p ≥ 0.75). Mean differences in body mass index (BMI) were associated with total (0.65 [0.23,1.06] kg; p < 0.01; I 2 = 56.9%) and trunk (0.56 [0.11,1.01] kg; p = 0.02; I 2 = 42.8%) LBM or FFM. The PCOS subgroup with BMI ≥ 25 kg/m 2 had greater total LBM or FFM versus controls (1.58 [0.82,2.34] kg; p < 0.01; I 2 = 64.0%) unlike the PCOS subgroup with BMI < 25 kg/m 2 (−0.45 [−1.94,1.05] kg; p = 0.53; I 2 = 69.5%). Appendicular lean mass and muscle strength data were contradictory and described narratively, as meta-analyses were impossible.

show abstract

Disparities in cardio metabolic risk between Black and White women with polycystic ovary syndrome: a systematic review and meta-analysis

Cited by 11 publications

References 134 publications

Sleep duration and chronotype of pregnant women in the United States: An online cross-sectional survey study

Sleep duration and chronotype of pregnant women in the United States: An online cross-sectional survey study

Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites

Obesity, but not hyperandrogenism or insulin resistance, predicts skeletal muscle mass in reproductive‐aged women with polycystic ovary syndrome: A systematic review and meta‐analysis of 45 observational studies

Contact Info

Product

Resources

About