Changes in fasting patterns during Ramadan, and associated clinical outcomes in adults with type 2 diabetes: A narrative review of epidemiological studies over the last 20 years

Hassanein, Mohamad M.; Hanif, Wasim; Malek, R.; Jabbar, Abdul

doi:10.1016/j.diabres.2020.108584

Cited by 9 publications

(11 citation statements)

References 41 publications

(78 reference statements)

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“…Consequently, projections point towards a large number of people with diabetes seeking to fast during Ramadan. Indeed, Hassanein et al highlighted the motivation among people with diabetes seeking to fast during Ramadan in a recent review [10].…”

Section: Introductionmentioning

confidence: 99%

Diabetes and Ramadan: Practical guidelines 2021

Hassanein

Afandi

Ahmedani

et al. 2022

Diabetes Research and Clinical Practice

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Section: Introductionmentioning

confidence: 99%

Diabetes and Ramadan: Practical guidelines 2021

Hassanein

Afandi

Ahmedani

et al. 2022

Diabetes Research and Clinical Practice

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“…In addition, a number of patients changed their meal type compared with the pre-Ramadan period, particularly by eating more carbohydrates during Ramadan, leading to a lower risk of hypoglycemia, but also by increasing proteins and to a lesser extent fats. This is highly relevant since changes in fasting patterns during Ramadan could be associated with clinical outcomes in T2DM patients [10]. Unfortunately, dietary changes during Ramadan have not been well analyzed in other studies and currently available information is scarce, with substantial disparities between previous studies, likely due to differences in culture and nutritional habits between regions [10, 26, 27].…”

Section: Discussionmentioning

confidence: 99%

A Real-World Study in Patients with Type 2 Diabetes Treated with Gliclazide Modified Release during Fasting in Gulf Cooperation Council Countries: An Analysis from the International DIA-RAMADAN Study

Hassanein

Sifri²,

Awadi

et al. 2022

Dubai Diabetes Endocrinol J

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Introduction: The safety and effectiveness of gliclazide modified release (MR) in patients with type 2 diabetes mellitus (T2DM) who fasted during Ramadan were previously published. Here, we carried out a regional analysis among patients living in Gulf Cooperation Council (GCC) countries. Patients and Methods: DIA-RAMADAN was a real-world, observational, international, noncomparative study conducted in nine countries that included >1200 T2DM adults receiving gliclazide MR for at least 90 days before inclusion. The study comprised 2 visits: at inclusion, 6–8 weeks before the start of Ramadan (V0) and 4–6 weeks after the end of Ramadan (V1). The primary endpoint was the proportion of patients reporting ≥1 symptomatic hypoglycemic event as collected using a patient diary. Changes in HbA1c, fasting plasma glucose (FPG), and weight were also analyzed. This manuscript represents data collected in GCC countries (Kuwait, Saudi Arabia, and United Arab Emirates). Results: Data from 161 patients were analyzed: mean (SD) age 56.8 (10.6) years, 30.4% women, body mass index 29.1 (3.7) kg/m2, T2DM disease duration 6.7 (3.3) years, baseline HbA1c 7.9% (0.8). The proportions of patients reporting ≥1 symptomatic hypoglycemic event or confirmed hypoglycemia during Ramadan were 4.3% and 0.6%, respectively. No cases of severe hypoglycemia were reported. Significant reductions in main variables were observed before the start of Ramadan (V0) and 4–6 weeks after the end of Ramadan (V1): HbA1c (from 7.9 [0.8] to 7.6 [0.7]%; p value <0.001), FPG (from 143.5 [24.3] to 137.9 [25.2] mg/dL; p value = 0.031), and weight (from 79.0 [73.0–86.0] to 78.0 [72.0–85.0] kg; p value = 0.018). Conclusions: These real-world data indicate that patients with T2DM treated with gliclazide MR during Ramadan in the selected GCC countries have a low risk of hypoglycemia and maintain glycemic control and weight while fasting.

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“…Thus, health care professionals must support individuals who choose to fast to minimize risks. Hassanein et al 9 reviewed three epidemiologic studies to understand how fasting patterns during Ramadan and associated clinical outcomes in adults with T2DM have evolved over two decades (2000–2020). Over a while, people with diabetes choosing to fast during Ramadan display increasingly complex profiles in terms of their diabetes, with increased disease duration, greater body mass index (BMI), and elevated pre-Ramadan mean glycated hemoglobin (HbA1c) levels.…”

Section: Highlights Of the Literaturementioning

confidence: 99%

Ramadan Fasting and Diabetes (2021): The Year in Review

Beshyah

Hafidh

Kenz

et al. 2022

Journal of Diabetes and Endocrine Practice

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Introduction The literature on the impact of Ramadan fasting (RF) on diabetes is widely spread in many journals. This makes it not readily accessible to those interested in the subject. We aimed to provide a narrative overview of the global literature production in 1 year (2021) on diabetes and RF. Materials and Methods This was a narrative, nonsystematic review of the international literature from a single major medical online database (i.e., PubMed) during the year 2021. The search term “Ramadan fasting AND Diabetes” was used, and the relevant literature was narrated in a concise thematic account. Results The publications spanned a vast array of topics related to diabetes and RF, including epidemiology, assessments of safety and efficacy profiles of older and newer diabetes therapies, hypoglycemia, diabetes education, use of advanced technology for the treatment, and monitoring and impact on pregnancy. Some reports covered the interaction of Ramadan and the novel coronavirus disease 2019 (COVID-19) in relationship to diabetes. Professional concerns, patients' perspectives, and telemedicine's role in RF were also addressed. Conclusion The current narration presents this year's literature on the safety of fasting practices, care models, and patients' experiences and perspectives. Work should continue on comprehensive assessments for the interplay of diabetes and RF under different settings. Particular attention should focus on the roles of newer antidiabetic medicines and advanced technology for safer fasting practices.

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Changes in fasting patterns during Ramadan, and associated clinical outcomes in adults with type 2 diabetes: A narrative review of epidemiological studies over the last 20 years

Cited by 9 publications

References 41 publications

Diabetes and Ramadan: Practical guidelines 2021

Diabetes and Ramadan: Practical guidelines 2021

A Real-World Study in Patients with Type 2 Diabetes Treated with Gliclazide Modified Release during Fasting in Gulf Cooperation Council Countries: An Analysis from the International DIA-RAMADAN Study

Ramadan Fasting and Diabetes (2021): The Year in Review

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