“…However, a recent systematic review and meta-analysis of human clinical trials and animal studies published prior to January 2020 showed that most publications on animal models reported positive outcomes on cognition and brain function following exposure to resveratrol or grape seed extracts. Conversely, eleven meta-analyses of data from human placebo vs. resveratrol, grape, or wine treatment trials did not find any statistically significant effect on various measures, including cognitive performance and mood assessments, gray matter volume, and blood pressure [313].…”
Multiple factors combined are currently recognized as contributors to cognitive decline. The main independent risk factor for cognitive impairment and dementia is advanced age followed by other determinants such as genetic, socioeconomic, and environmental factors, including nutrition and physical activity. In the next decades, a rise in dementia cases is expected due largely to the aging of the world population. There are no hitherto effective pharmaceutical therapies to treat age-associated cognitive impairment and dementia, which underscores the crucial role of prevention. A relationship among diet, physical activity, and other lifestyle factors with cognitive function has been intensively studied with mounting evidence supporting the role of these determinants in the development of cognitive decline and dementia, which is a chief cause of disability globally. Several dietary patterns, foods, and nutrients have been investigated in this regard, with some encouraging and other disappointing results. This review presents the current evidence for the effects of dietary patterns, dietary components, some supplements, physical activity, sleep patterns, and social engagement on the prevention or delay of the onset of age-related cognitive decline and dementia.
“…However, a recent systematic review and meta-analysis of human clinical trials and animal studies published prior to January 2020 showed that most publications on animal models reported positive outcomes on cognition and brain function following exposure to resveratrol or grape seed extracts. Conversely, eleven meta-analyses of data from human placebo vs. resveratrol, grape, or wine treatment trials did not find any statistically significant effect on various measures, including cognitive performance and mood assessments, gray matter volume, and blood pressure [313].…”
Multiple factors combined are currently recognized as contributors to cognitive decline. The main independent risk factor for cognitive impairment and dementia is advanced age followed by other determinants such as genetic, socioeconomic, and environmental factors, including nutrition and physical activity. In the next decades, a rise in dementia cases is expected due largely to the aging of the world population. There are no hitherto effective pharmaceutical therapies to treat age-associated cognitive impairment and dementia, which underscores the crucial role of prevention. A relationship among diet, physical activity, and other lifestyle factors with cognitive function has been intensively studied with mounting evidence supporting the role of these determinants in the development of cognitive decline and dementia, which is a chief cause of disability globally. Several dietary patterns, foods, and nutrients have been investigated in this regard, with some encouraging and other disappointing results. This review presents the current evidence for the effects of dietary patterns, dietary components, some supplements, physical activity, sleep patterns, and social engagement on the prevention or delay of the onset of age-related cognitive decline and dementia.
“…Thus, when SIRT1 was identified as a potential target for resveratrol, a compound enriched in red grapes [300], resveratrol became a popular strategy for the induction of endogenous PGC-1α activity and/or expression. While there are reports of resveratrol treatment increasing PGC-1α, NRF-1, and TFAM expression in the hippocampus [301] with some evidence for effects on cognition and mood in mouse models [302,303], trials in humans have been inconclusive [301], potentially due to its low bioavailability [304].…”
Section: Stimulating Increases In Endogenous Expression Of Pgc-1α Andmentioning
Substantial evidence indicates that mitochondrial impairment contributes to neuronal dysfunction and vulnerability in disease states, leading investigators to propose that the enhancement of mitochondrial function should be considered a strategy for neuroprotection. However, multiple attempts to improve mitochondrial function have failed to impact disease progression, suggesting that the biology underlying the normal regulation of mitochondrial pathways in neurons, and its dysfunction in disease, is more complex than initially thought. Here, we present the proteins and associated pathways involved in the transcriptional regulation of nuclear-encoded genes for mitochondrial function, with a focus on the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α). We highlight PGC-1α’s roles in neuronal and non-neuronal cell types and discuss evidence for the dysregulation of PGC-1α-dependent pathways in Huntington’s Disease, Parkinson’s Disease, and developmental disorders, emphasizing the relationship between disease-specific cellular vulnerability and cell-type-specific patterns of PGC-1α expression. Finally, we discuss the challenges inherent to therapeutic targeting of PGC-1α-related transcriptional programs, considering the roles for neuron-enriched transcriptional coactivators in co-regulating mitochondrial and synaptic genes. This information will provide novel insights into the unique aspects of transcriptional regulation of mitochondrial function in neurons and the opportunities for therapeutic targeting of transcriptional pathways for neuroprotection.
“…Moreover, there is another issue related to ammonia-induced cell swelling under certain concentrations, as described above [118]. Moreover, there were meta-analyses suggesting that the effect of resveratrol on the cognitive effects of the human brain may be limited [35,36]. Although more studies are required to scrutinize these points, resveratrol is still expected to be a promising candidate for the treatment of HE, according to its diverse effects related to HE described in this review.…”
Section: Discussionmentioning
confidence: 87%
“…Although a meta-analysis study suggested that resveratrol has no significant effect on cognitive function [34], another meta-analysis study indicated that oral resveratrol treatment improves some cognitive performances in subjects [35]. Based on these reports, the effect of resveratrol on cognitive improvement has so far been controversial [36].…”
Hepatic encephalopathy is a common complication in patients with liver cirrhosis and portosystemic shunting. Patients with hepatic encephalopathy present a variety of clinical features, including neuropsychiatric manifestations, cognitive dysfunction, impaired gut barrier function, hyperammonemia, and chronic neuroinflammation. These pathogeneses have been linked to various factors, including ammonia-induced oxidative stress, neuronal cell death, alterations in the gut microbiome, astrocyte swelling, and blood-brain barrier disruptions. Many researchers have focused on identifying novel therapeutics and prebiotics in the hope of improving the treatment of these conditions. Resveratrol is a natural polyphenic compound and is known to exert several pharmacological effects, including antioxidant, anti-inflammatory, and neuroprotective activities. Recent studies suggest that resveratrol contributes to improving the neuropathogenic effects of liver failure. Here, we review the current evidence describing resveratrol’s effects in neuropathogenesis and its impact on the gut-liver axis relating to hepatic encephalopathy. We highlight the hypothesis that resveratrol exerts diverse effects in hepatic encephalopathy and suggest that these effects are likely mediated by changes to the gut microbiota, brain edema, and neuroinflammation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.