Increasing changes in visceral adiposity is associated with higher risk for colorectal adenoma: Multilevel analysis in a prospective cohort

Moon, Jeong Min; Im, Jong Pil; Kim, Dong‐Hee; Han, Yoo Min; Soh, Hosim; Song, Ji Hyun; Yang, Sun Young; Kim, Young Sun; Yim, Jeong Yoon; Lim, Seon Hee; Kim, Sang Woo

doi:10.1111/jgh.15364

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…Excessive fat beyond the capacity of SAT is stored in ectopic fat, the so-called VAT [ 35 ]. However, in terms of colonic adenomas, SAT was not a significant risk factor for colonic adenoma in previous studies [ 13 , 14 , 36 ]. Previous studies have reported that SAT correlates with fat mass measured using BIA.…”

Section: Discussionmentioning

confidence: 66%

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Visceral Obesity Is a More Important Factor for Colorectal Adenomas than Skeletal Muscle or Body Fat

Seo

Han

Chung

et al. 2022

Cancers

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Objective: Although the incidence of colorectal adenomas increases with obesity, the role of various body compositions is still unknown. We aimed to determine which body composition best reflects the risk of colorectal adenomas. Methods: Patients aged 50–75 years who underwent colonoscopy and a bioelectrical impedance analysis (BIA) for a health check-up from 2017 to 2019 were retrospectively enrolled. The skeletal muscle index (SMI), fat mass index (FMI), and visceral fat index (VFI) were obtained using BIA. The muscle-to-fat ratio (MFR) and the skeletal muscle mass to visceral fat area ratio (SVR) were calculated. Results: Among 15,102 patients, 6605 (43.7%) had adenomas. SMI, FMI, MFR, VFI, and SVR were all associated with the risk of adenomas and high-risk adenomas in the age- and sex-adjusted model. When further adjusted for metabolic and lifestyle factors, VFI was the only factor significantly associated with the risk of colorectal adenomas and high-risk adenomas (adenomas: odds ratio (OR) 1.40, 95% confidence interval (CI) 1.22–1.61; high-risk adenomas: OR 1.47, 95% CI 1.16–1.87, for the highest quartile). Conclusion: Among the various body indices, VFI was the most important index associated with the development of colorectal adenoma. More attention should be paid to visceral fat when predicting the risk of colorectal adenomas.

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Section: Discussionmentioning

confidence: 66%

“…VFA measured using computed tomography (CT) scans has been widely studied and shown to have a positive relationship with adenomas [ 13 ]. In a longitudinal study, increased VFA increased both incident and recurrent colorectal adenomas [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Visceral Obesity Is a More Important Factor for Colorectal Adenomas than Skeletal Muscle or Body Fat

Seo

Han

Chung

et al. 2022

Cancers

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“…Although the association between VAT and CRC was controversial, its association with colorectal polyp was quite well established [ 31 , 32 ]. Various studies have demonstrated that increase in VAT area was an independent risk factor for colorectal polyp [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Abdominal fat and muscle distributions in different stages of colorectal cancer

et al. 2023

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Background The purpose of this study is to explore the difference of abdominal fat and muscle composition, especially subcutaneous and visceral adipose tissue, in different stages of colorectal cancer (CRC). Materials and methods Patients were divided into 4 groups: healthy controls (patients without colorectal polyp), polyp group (patients with colorectal polyp), cancer group (CRC patients without cachexia), and cachexia group (CRC patients with cachexia). Skeletal muscle (SM), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and intermuscular adipose tissue (IMAT) were assessed at the third lumbar level on computed tomography images obtained within 30 days before colonoscopy or surgery. One-way ANOVA and linear regression were used to analyze the difference of abdominal fat and muscle composition in different stages of CRC. Results A total of 1513 patients were divided into healthy controls, polyp group, cancer group, and cachexia group, respectively. In the development of CRC from normal mucosa to polyp and cancer, the VAT area of the polyp group was significantly higher than that of the healthy controls both in male (156.32 ± 69.71 cm2 vs. 141.97 ± 79.40 cm2, P = 0.014) and female patients (108.69 ± 53.95 cm2 vs. 96.28 ± 46.70 cm2, P = 0.044). However, no significant differences were observed of SAT area between polyp group and healthy controls in both sexes. SAT area decreased significantly in the male cancer group compared with the polyp group (111.16 ± 46.98 cm2 vs. 126.40 ± 43.52 cm2, P = 0.001), while no such change was observed in female patients. When compared with healthy controls, the SM, IMAT, SAT, and VAT areas of cachexia group was significantly decreased by 9.25 cm2 (95% CI: 5.39–13.11 cm2, P < 0.001), 1.93 cm2 (95% CI: 0.54–3.32 cm2, P = 0.001), 28.84 cm2 (95% CI: 17.84–39.83 cm2, P < 0.001), and 31.31 cm2 (95% CI: 18.12–44.51 cm2, P < 0.001) after adjusting for age and gender. Conclusion Abdominal fat and muscle composition, especially SAT and VAT, was differently distributed in different stages of CRC. It is necessary to pay attention to the different roles of subcutaneous and visceral adipose tissue in the development of CRC.

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“…Moreover, a recent study showed that increase in visceral adiposity was associated with a higher risk for CRA, indicating there might also be changes in the severity of NAFLD. 5 We propose that severity of NAFLD and onset time of first diagnosis could be reported to better explain the conclusion.…”

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confidence: 86%

Serum pancreatic amylase and colorectal adenoma: From clinical research to practice

Liu

Bian

2022

J of Gastro and Hepatol

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Increasing changes in visceral adiposity is associated with higher risk for colorectal adenoma: Multilevel analysis in a prospective cohort

Abstract: Moon was involved in the acquisition of data, analysis and interpretation of data, and drafting of the manuscript.

Cited by 5 publications

References 33 publications

Visceral Obesity Is a More Important Factor for Colorectal Adenomas than Skeletal Muscle or Body Fat

Visceral Obesity Is a More Important Factor for Colorectal Adenomas than Skeletal Muscle or Body Fat

Abdominal fat and muscle distributions in different stages of colorectal cancer

Serum pancreatic amylase and colorectal adenoma: From clinical research to practice

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