Moody kids years later: Long-term outcomes of youth from the Omega-3 and therapy (OATS) studies

Fristad, Mary A.; Roley‐Roberts, Michelle E.; Black, Simon; Arnold, L. Eugene

doi:10.1016/j.jad.2020.11.115

Cited by 10 publications

(15 citation statements)

References 58 publications

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“…In addition to the thirteen RCTs, there were two open label trials [ 35 , 36 ] and one observational study [ 37 ]. Finally, one other report identified in the grey literature search was included with these additional studies because it reported on empirical data, despite not being peer-reviewed [ 38 ]; see S6 Table for non-RCT characteristics.…”

Section: Resultsmentioning

confidence: 99%

Omega-3 supplements in the prevention and treatment of youth depression and anxiety symptoms: A scoping review

et al. 2023

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Introduction Omega-3 supplements may be efficacious in reducing symptoms of depression and anxiety in adults, particularly as an adjunct to antidepressant medication. However, research in young people is limited. Thus, this scoping review aimed to summarise existing evidence on the efficacy of omega-3 supplementation in treating depression and anxiety symptoms in young people aged 14–24. A secondary aim was to determine whether grey literature intended for the general public accurately reflects the evidence. Method Four databases (Cochrane CENTRAL, EmBASE, PsycINFO, PubMed) were searched from inception to 4th August 2021. Eligible peer-reviewed studies were empirical studies which examined the efficacy of omega-3 supplements in preventing/treating anxiety and/or depression symptoms in young people aged 14–24. Risk of bias was assessed for randomised studies using the Cochrane Risk of Bias Tool. Selected grey literature databases were also searched, with eligible sources assessed for quality. A stakeholder group including young people with lived experience of anxiety/depression, parents/carers and mental health professionals informed the research questions and data interpretation. Findings were summarised using narrative synthesis. Results 17 empirical studies (N = 1240 participants) meeting inclusion criteria were identified. Studies varied in treatment and participant characteristics. In general, the data did not support the view that omega-3 supplements were efficacious in improving symptoms of anxiety or depression in young people aged 14–24. In contrast, most grey literature sources recommended the use of omega-3 supplements in young people. Discussion Evidence for efficacy of omega-3 supplementation in reducing symptoms of depression and anxiety in young people was inconclusive. More research is needed to identify potential mechanisms and moderators of the effect of omega-3 supplements on depression and anxiety symptoms in young people.

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Section: Resultsmentioning

confidence: 99%

Omega-3 supplements in the prevention and treatment of youth depression and anxiety symptoms: A scoping review

et al. 2023

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“…All studies targeted young populations (e.g., ≤19 years), except one [ 35 ] that included participants aged from 9 to 21 years. Considering the symptomatology, five studies identified existing Major Depressive Disorder (MDD), Mixed Anxiety and Depressive Disorders (MADD), Dysthymic Disorder (DD), or Depressive Disorder Not Otherwise Specified (DD-NOS) [ 35 , 36 , 37 , 38 , 39 ]. Among this research, one study required that the participants had at least one biological parent with Bipolar I disorder [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…Three studies compared the effectiveness of a combined treatment. Among these three, two studies provided an oral supplementation of Omega-3 with Psycho-Educational Psychotherapy (PEP) to the experimental group [ 36 , 37 ], while the third study provided an oral supplementation of Vitamin D 3 with Treatment As Usual (TAU) (in agreement with the clinical guidelines) for the experimental group [ 40 ]. Although the term “probiotics” was among the search keywords, no results were found.…”

Section: Resultsmentioning

confidence: 99%

Need for Multidimensional and Multidisciplinary Management of Depressed Preadolescents and Adolescents: A Review of Randomized Controlled Trials on Oral Supplementations (Omega-3, Fish Oil, Vitamin D3)

Pruneti

Guidotti

2023

Nutrients

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(1) Background: Depression is a serious health problem with a high cost for public administration. Epidemiological studies report that one in five children have a mental disorder and about 50% of mental health problems exacerbate in childhood and adolescence. Moreover, the antidepressant efficacy in children and adolescents is poorly demonstrated and can cause severe behavioral adverse events such as suicidal ideation. (2) Methods: This systematic literature review examined oral supplementations (Omega-3, fish oil, Vitamin D3) to treat depressed children, preadolescents, and adolescents. MEDLINE, Scopus, Embase, and PsycInfo were searched for articles published in the last five years. Six studies met the eligibility criteria. The inclusion criteria encompassed children, preadolescents, and adolescents, a diagnosis of depression, and an intervention of oral supplementations such as Omega-3, fish oil, and Vitamin D3. (3) Results: Most of the studies demonstrated that dietary intervention provides positive outcomes in terms of depression symptoms. (4) Conclusions: Overall, the results demonstrate a positive effect for oral supplementation suggesting an increase intake of Omega-3, fish oil, and Vitamin D3. However, only a few studies assess the effectiveness of diet recommendations, as a monotherapy or combined treatment, for the management of depression at developmental ages. Thus, there is still a need to further investigate these aspects and to look more specifically at adolescents and preadolescents.

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“…In addition to the thirteen RCTs, there were two open label trials (31, 32) and one observational study (33). Finally, one other report identified in the grey literature search was included with these additional studies because it reported on empirical data despite not being peer-reviewed (34; see Supplementary Table 5 for non-RCT characteristics).…”

Section: Resultsmentioning

confidence: 99%

Omega-3 supplements in the prevention and treatment of youth depression and anxiety: A scoping review

Reily

Tang

Negrone

et al. 2022

Preprint

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Introduction: Emerging evidence suggests that omega-3 supplements may be efficacious in reducing symptoms of depression and anxiety in adults, particularly as an adjunct to antidepressant medication. However, research on its efficacy in young people is limited. Thus, this scoping review aimed to summarise existing evidence on the efficacy of omega-3 supplementation in treating depression and anxiety in young people aged 14-24. Method: Four databases (Cochrane CENTRAL, EmBASE, PsycINFO and PubMed) were searched from inception to 4th August 2021. Eligible peer-reviewed studies were empirical studies which examined the efficacy of omega-3 supplements in preventing/treating anxiety and/or depression in young people aged 14-24. Risk of bias was assessed for randomised studies using the Cochrane Risk of Bias Tool. Selected grey literature databases were also searched, with eligible sources assessed for quality. A group of stakeholders consisting of young people with lived experience of anxiety/depression, parents/carers and mental health professionals informed the research questions and data interpretation. Findings were summarised using narrative synthesis. Results: 17 empirical studies (N = 1240 participants) meeting inclusion criteria were identified. Studies varied in treatment and participant characteristics. In general, the data did not support the view that omega-3 supplements were efficacious in improving symptoms of anxiety or depression. In contrast, most grey literature sources recommended the use of omega-3 supplements despite the lack of supporting evidence. Discussion: Evidence for efficacy of omega-3 supplementation in reducing symptoms of depression and anxiety was inconclusive. More research is needed to identify potential mechanisms and moderators of the effect of omega-3 supplements on depression and anxiety symptoms in young people.

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Moody kids years later: Long-term outcomes of youth from the Omega-3 and therapy (OATS) studies

Cited by 10 publications

References 58 publications

Omega-3 supplements in the prevention and treatment of youth depression and anxiety symptoms: A scoping review

Omega-3 supplements in the prevention and treatment of youth depression and anxiety symptoms: A scoping review

Need for Multidimensional and Multidisciplinary Management of Depressed Preadolescents and Adolescents: A Review of Randomized Controlled Trials on Oral Supplementations (Omega-3, Fish Oil, Vitamin D3)

Omega-3 supplements in the prevention and treatment of youth depression and anxiety: A scoping review

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