Notch receptor GLP-1 regulates toxicity of simulated microgravity stress by activating germline-intestine communication of insulin signaling in C. elegans

Liu, Huanliang; Tian, Lijie; Wang, Dayong

doi:10.1016/j.bbrc.2020.11.102

Cited by 23 publications

(4 citation statements)

References 22 publications

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“…Insulin peptides are conserved regulators for a broad spectrum of biological processes, such as energy consumption, neural activity, stress resistance, and lifespan. − Insulin-like peptides function as agonists or antagonist of DAF-2 to influence the biological process. , It has been reported that environmental pollutants or stress could induce toxicity through affecting insulin peptides, such as nanoplastics and microgravity. − In this study, 6-PPDQ exposure significantly increased ins-7 , ins-6 , and daf-28 expressions (Figure A). Meanwhile, ins-7(RNAi) , ins-6(RNAi) , and daf-28(RNAi) nematodes were resistant to 6-PPDQ toxicity on lifespan and healthspan (Figure C–E).…”

Section: Results and Discussionmentioning

confidence: 59%

Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans

Hua,

Wang

2023

Environ. Sci. Technol.

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Section: Results and Discussionmentioning

confidence: 59%

Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans

Hua,

Wang

2023

Environ. Sci. Technol.

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“…The corresponding Notch receptors are LIN-12 and GLP-1 [ 51 ]. Notch receptor GLP-1 is involved in regulating the toxicity of CdTe quantum dots and simulated microgravity [ 52 , 53 ]. Moreover, we focused on the Notch signal in the germline to determine its possible involvement in mediating transgenerational PS-S NP toxicity.…”

Section: Introductionmentioning

confidence: 99%

Sulfonate-Modified Polystyrene Nanoparticle at Precited Environmental Concentrations Induces Transgenerational Toxicity Associated with Increase in Germline Notch Signal of Caenorhabditis elegans

Wang

2023

Toxics

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Recently, the transgenerational toxicity of nanoplastics has received increasing attention. Caenorhabditis elegans is a useful model to assess the transgenerational toxicity of different pollutants. In nematodes, the possibility of early-life exposure to sulfonate-modified polystyrene nanoparticle (PS-S NP) causing transgenerational toxicity and its underlying mechanisms were investigated. After exposure at the L1-larval stage, transgenerational inhibition in both locomotion behavior (body bend and head thrash) and reproductive capacity (number of offspring and fertilized egg number in uterus) was induced by 1–100 μg/L PS-S NP. Meanwhile, after exposure to 1–100 μg/L PS-S NP, the expression of germline lag-2 encoding Notch ligand was increased not only at the parental generation (P0-G) but also in the offspring, and the transgenerational toxicity was inhibited by the germline RNA interference (RNAi) of lag-2. During the transgenerational toxicity formation, the parental LAG-2 activated the corresponding Notch receptor GLP-1 in the offspring, and transgenerational toxicity was also suppressed by glp-1 RNAi. GLP-1 functioned in the germline and the neurons to mediate the PS-S NP toxicity. In PS-S NP-exposed nematodes, germline GLP-1 activated the insulin peptides of INS-39, INS-3, and DAF-28, and neuronal GLP-1 inhibited the DAF-7, DBL-1, and GLB-10. Therefore, the exposure risk in inducing transgenerational toxicity through PS-S NP was suggested, and this transgenerational toxicity was mediated by the activation of germline Notch signal in organisms.

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“…Caenorhabditis elegans is a classical model animal . Meanwhile, C. elegans shows a high sensitivity to environmental exposure to different toxicants or stresses. − Using this animal model, different aspects of NPs toxicity could be detected. For example, exposure to MPs or NPs could cause damage on intestinal function. − High concentrations of MPs or NPs could reduce the lifespan of worms. , Additionally, long-term exposure to polystyrene nanoparticles (PS-NPs) could induce the transgenerational toxicity in nematodes …”

Section: Introductionmentioning

confidence: 99%

Induction of Protective Response Associated with Expressional Alterations in Neuronal G Protein-Coupled Receptors in Polystyrene Nanoparticle Exposed Caenorhabditis elegans

Yang

Dong

et al. 2021

Chem. Res. Toxicol.

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Notch receptor GLP-1 regulates toxicity of simulated microgravity stress by activating germline-intestine communication of insulin signaling in C. elegans

Cited by 23 publications

References 22 publications

Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans

Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans

Sulfonate-Modified Polystyrene Nanoparticle at Precited Environmental Concentrations Induces Transgenerational Toxicity Associated with Increase in Germline Notch Signal of Caenorhabditis elegans

Induction of Protective Response Associated with Expressional Alterations in Neuronal G Protein-Coupled Receptors in Polystyrene Nanoparticle Exposed Caenorhabditis elegans

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