Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Volz, Erik; Hill, Verity; McCrone, John; Price, Anna; Jorgensen, David A.; O’Toole, Áine; Southgate, Joel; Johnson, Robert A.; Jackson, Ben; Nascimento, Fabrícia F.; Rey, Sara; Nicholls, Samuel M.; Colquhoun, Rachel; Filipe, Ana da Silva; Shepherd, James G.; Pascall, David; Shah, Rajiv; Jesudason, Natasha; Li, Kathy; Jarrett, Ruth F.; Pacchiarini, Nicole; Bull, Matthew; Geidelberg, Lily; Siveroni, Igor; Goodfellow, Ian; Loman, Nicholas J.; Pybus, Oliver G.; Robertson, David L.; Thomson, Emma C.; Rambaut, Andrew; Connor, Thomas R.

doi:10.1016/j.cell.2020.11.020

Cited by 909 publications

(838 citation statements)

References 55 publications

(52 reference statements)

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“…Further work should clarify the role, if any, of increased mobility and population mixing that may have been concurrent with the circulation of the 501Y Variant 2 in explaining higher transmissibility. In particular, this should be done through comparison with contact tracing results of clusters of cases of 501Y Variant 2 [ 19 ]. Assessment of clinical severity changes associated with the new variants would require several more weeks of close and careful observation [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, this should be done through comparison with contact tracing results of clusters of cases of 501Y Variant 2 [ 19 ]. Assessment of clinical severity changes associated with the new variants would require several more weeks of close and careful observation [ 19 , 20 ]. Finally, given the numerous mutations associated with 501Y variants, and thus the potential for antigenic changes, intensified immunogenomic surveillance is necessary to identify instances of re-infection in previous confirmed COVID-19 patients, as well as breakthrough infections among those who have been vaccinated.…”

Section: Discussionmentioning

confidence: 99%

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Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

et al. 2021

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Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6–13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70–80%) more transmissible than the 501N lineage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

et al. 2021

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“…2). Preliminary studies suggest that the D614G mutation can enhance viral infectivity in cell culture 18 and phylodynamic approaches have shown an increase in growth and size of lineages with this mutation 19 . Nevertheless, it is noteworthy that the increase in glycine in New Zealand samples is due to multiple importation events of this variant rather than selection for this mutation within New Zealand.…”

Section: Resultsmentioning

confidence: 99%

Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand

et al. 2020

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New Zealand, a geographically remote Pacific island with easily sealable borders, implemented a nationwide ‘lockdown’ of all non-essential services to curb the spread of COVID-19. Here, we generate 649 SARS-CoV-2 genome sequences from infected patients in New Zealand with samples collected during the ‘first wave’, representing 56% of all confirmed cases in this time period. Despite its remoteness, the viruses imported into New Zealand represented nearly all of the genomic diversity sequenced from the global virus population. These data helped to quantify the effectiveness of public health interventions. For example, the effective reproductive number, Re of New Zealand’s largest cluster decreased from 7 to 0.2 within the first week of lockdown. Similarly, only 19% of virus introductions into New Zealand resulted in ongoing transmission of more than one additional case. Overall, these results demonstrate the utility of genomic pathogen surveillance to inform public health and disease mitigation.

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“…While infectiousness and transmissibility are closely related, they are not necessarily synonymous to one another, and therefore, detailed studies are needed to decide whether or not the D614G mutation has contributed to an increase in the number of infections and not simply higher viral loads during infection ( Volz et al, 2021 and COVID-19 Genomics UK Consortium, 2020a ). Interestingly the entire region is sharing the same common mutations within the same clades ( COVID-19 Genomics UK Consortium, 2020b ).…”

Section: Discussionmentioning

confidence: 99%

Molecular epidemiology of COVID-19 in Oman: A molecular and surveillance study for the early transmission of COVID-19 in the country

Al-Mahruqi

Wahaibi

Khan

et al. 2021

International Journal of Infectious Diseases

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Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been proven to be lethal to human health, which affects almost every corner of the world. The objectives of this study were to add context to the global data and international genomic consortiums, and to give insight into the efficiency of the contact tracing system in Oman. Methods: We combined epidemiological data and whole-genome sequence data from 94 samples of SARS-CoV-2 in Oman to understand the origins, genetic variation, and transmissibility. The wholegenome size of sequence data was obtained through a customized SARS-COV-2 research panel. Amplifier methods ranged from 26 Kbp to 30 Kbp and were submitted to GISAID. Findings: The study found that P323L (94.7%) is the most common mutation, followed by D614G (92.6%) Spike protein mutation. A unique mutation, I280V, was first reported in Oman and was associated with a rare lineage, B.1.113 (10.6%). In addition, the study revealed a good agreement between genetic and epidemiological data. Interpretation: Oman's robust surveillance system was very efficient in guiding the outbreak investigation processes in the country, the study illustrates the future importance of molecular epidemiology in leading the national response to outbreaks and pandemics.

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Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Cited by 909 publications

References 55 publications

Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand

Molecular epidemiology of COVID-19 in Oman: A molecular and surveillance study for the early transmission of COVID-19 in the country

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