A greener protocol for the synthesis of phosphorochalcogenoates: Antioxidant and free radical scavenging activities

Mailahn, Daniela H.; Iarocz, Lucas E. B.; Nobre, Patrick C.; Perin, Gelson; Sinott, Airton; Pesarico, Ana Paula; Birmann, Paloma T.; Savegnago, Lucielli; Silva, Márcio S.

doi:10.1016/j.ejmech.2020.113052

Cited by 8 publications

(2 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The activity of these α-amino phosphonates compounds therefore appears to be dependent on their chemical structure. The group have described the synthesis of new organophosphate compounds, the phosphoroselenoates 175 [118]. Eleven compounds were prepared in 82-98% yield, by the reaction between diorganyl diselenide 4 and diorganyl H-phosphonate 174 in DMSO at 50 °C for 1-4 h (Scheme 47).…”

Section: Miscellaneousmentioning

confidence: 99%

“…It was demonstrated that, in ex vivo assays, at a dose of 10 mg/kg, compounds 175f and 175g reduced lipid peroxidation levels in the brain of mice, while compounds 175a, 175c, and 175g decreased GPx activity, and 175f-g decreased SOD activity. The group have described the synthesis of new organophosphate compounds, the phosphoroselenoates 175 [118]. Eleven compounds were prepared in 82-98% yield, by the reaction between diorganyl diselenide 4 and diorganyl H-phosphonate 174 in DMSO at 50 • C for 1-4 h (Scheme 47).…”

Section: Miscellaneousmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

Anghinoni,

Birmann,

da Rocha

et al. 2023

Molecules

Self Cite

View full text Add to dashboard Cite

Selenium is an essential trace element in living organisms, and is present in selenoenzymes with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). The search for small selenium-containing molecules that mimic selenoenzymes is a strong field of research in organic and medicinal chemistry. In this review, we review the synthesis and bioassays of new and known organoselenium compounds with antioxidant activity, covering the last five years. A detailed description of the synthetic procedures and the performed in vitro and in vivo bioassays is presented, highlighting the most active compounds in each series.

show abstract

Section: Miscellaneousmentioning

confidence: 99%

Section: Miscellaneousmentioning

confidence: 99%

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

Anghinoni,

Birmann,

da Rocha

et al. 2023

Molecules

Self Cite

View full text Add to dashboard Cite

show abstract

A Promoter‐free Protocol for the Synthesis of Selenophosphates and Thiophosphates via a Spontaneous Process at Room Temperature

et al. 2022

View full text Add to dashboard Cite

show abstract

Synthesis of Phosphate Esters by Using Diphenyl Ditelluride as Organocatalyst

et al. 2023

Self Cite

View full text Add to dashboard Cite

We report a protocol for the synthesis of new dialkyl(1‐(organolthio)naphthalen‐2‐yl)phosphates and derivatives via a dehydrogenative phosphorylation reaction between functionalized naphthols and H‐phosphonates. Diphenyl ditelluride was employed as an organocatalyst and sonochemistry as an alternative energy source. The reaction conditions were defined through a factorial design approach, and the best condition provided the synthesis of dialkyl(1‐(organolthio)naphthalen‐2‐yl)phosphates in yields that varied from 51–98 % under ultrasound irradiation after 2 h of sonication. The synthetic protocol was also effective for phenol and thiophenol starting materials. All products were characterized by state‐of‐the‐art spectroscopic and spectrometric techniques.

show abstract

A greener protocol for the synthesis of phosphorochalcogenoates: Antioxidant and free radical scavenging activities

Cited by 8 publications

References 69 publications

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

A Promoter‐free Protocol for the Synthesis of Selenophosphates and Thiophosphates via a Spontaneous Process at Room Temperature

Synthesis of Phosphate Esters by Using Diphenyl Ditelluride as Organocatalyst

Contact Info

Product

Resources

About