Effect of bacterial contamination in bile on pancreatic cancer cell survival

Shrader, Hannah R.; Miller, Ann L.; Tomanek-Chalkley, Ann; McCarthy, Ashley; Coleman, Kristen L.; Ear, Po Hien; Mangalam, Ashutosh K.; Salem, Aliasger K.; Chan, Carlos

doi:10.1016/j.surg.2020.09.029

Cited by 17 publications

(23 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bile samples were obtained from patients undergoing a Pancreaticoduodenectomy. All sterile bile ( n = 4) reduced PDAC cell survival in vitro, while contaminated bile samples exhibited a reduced anti-tumour effect [ 160 ]. Conversely, pre-incubation of sterile bile with live bacteria altered the antitumor effect of sterile bile [ 160 ].…”

Section: Discussionmentioning

confidence: 99%

“…All sterile bile ( n = 4) reduced PDAC cell survival in vitro, while contaminated bile samples exhibited a reduced anti-tumour effect [ 160 ]. Conversely, pre-incubation of sterile bile with live bacteria altered the antitumor effect of sterile bile [ 160 ]. This study showed that a change in the biliary microbiome through stenting directly impacts PDAC cell survival in vitro.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Comprehensive Review of the Current and Future Role of the Microbiome in Pancreatic Ductal Adenocarcinoma

Merali

Chouari

Kayani

et al. 2022

Cancers

View full text Add to dashboard Cite

Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second most common cause of cancer death in the USA by 2030, yet progress continues to lag behind that of other cancers, with only 9% of patients surviving beyond 5 years. Long-term survivorship of PDAC and improving survival has, until recently, escaped our understanding. One recent frontier in the cancer field is the microbiome. The microbiome collectively refers to the extensive community of bacteria and fungi that colonise us. It is estimated that there is one to ten prokaryotic cells for each human somatic cell, yet, the significance of this community in health and disease has, until recently, been overlooked. This review examines the role of the microbiome in PDAC and how it may alter survival outcomes. We evaluate the possibility of employing microbiomic signatures as biomarkers of PDAC. Ultimately this review analyses whether the microbiome may be amenable to targeting and consequently altering the natural history of PDAC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Comprehensive Review of the Current and Future Role of the Microbiome in Pancreatic Ductal Adenocarcinoma

Merali

Chouari

Kayani

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…Bile acid can change the microvilli structure on the surface of PC cells and affect the function of mitochondria in cancer cells. Therefore, it is speculated that bile acid can affect the proliferation and invasion of PC cells through cytotoxic effects ( Lu et al., 2000 ; Shrader et al., 2021 ). The gut microbiota is involved in the catabolism of bile acids, which inhibits the conversion rate of primary bile acids to secondary bile acids.…”

Section: Mechanisms By Which the Gut Microbiota Causes Pcmentioning

confidence: 99%

Potential Roles of the Gut Microbiota in Pancreatic Carcinogenesis and Therapeutics

Yang

Zhang

Zhu

2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The intestinal microenvironment is composed of normal gut microbiota and the environment in which it lives. The largest microecosystem in the human body is the gut microbiota, which is closely related to various diseases of the human body. Pancreatic cancer (PC) is a common malignancy of the digestive system worldwide, and it has a 5-year survival rate of only 5%. Early diagnosis of pancreatic cancer is difficult, so most patients have missed their best opportunity for surgery at the time of diagnosis. However, the etiology is not entirely clear, but there are certain associations between PC and diet, lifestyle, obesity, diabetes and chronic pancreatitis. Many studies have shown that the translocation of the gut microbiota, microbiota dysbiosis, imbalance of the oral microbiota, the interference of normal metabolism function and toxic metabolite products are closely associated with the incidence of PC and influence its prognosis. Therefore, understanding the correlation between the gut microbiota and PC could aid the diagnosis and treatment of PC. Here, we review the correlation between the gut microbiota and PC and the research progresses for the gut microbiota in the diagnosis and treatment of PC.

show abstract

“…Acinetobacter, Enterobacter, Pseudomonas, Delftia, Enterococcus, Streptococcus, Corynebacterium, Propionibacterium, Sphingomonas, and Staphylococcus with a significant Klebsiella predominance were found in the human PanCa group compared to the healthy control (samples from organ donations)[ 32 ]. In addition, higher levels of Malassezia species in cancer tissue were related to PanCa progression, while Candida, Aspergillus, or Saccharomyces species did not cause cancer development after repopulation following mycobiome ablation[ 34 ]. In animal models, a relatively higher abundance of Lactobacillus was found in the pancreatic tissue of the control group, while a relatively higher abundance of Fusobacterium species and Proteobacteria were found in the pancreatic tissue of the cancer group[ 17 , 33 ].…”

Section: Cancer Developmentmentioning

confidence: 99%

Impact of microbiota-immunity axis in pancreatic cancer management

Bartolini¹,

Nannini²,

Risaliti³

et al. 2022

WJG

View full text Add to dashboard Cite

The microbiota impact on human diseases is well-known, and a growing body of literature is providing evidence about the complex interplay between microbiota-immune system-human physiology/pathology, including cancers. Together with the defined risk factors ( e.g. , smoke habits, diet, diabetes, and obesity), the oral, gut, biliary, and intrapancreatic microbiota contribute to pancreatic cancer development through different pathways including the interaction with the immune system. Unfortunately, a great majority of the pancreatic cancer patients received a diagnosis in advanced stages not amenable to be radically treated and potentially cured. Given the poor pancreatic cancer prognosis, complete knowledge of these complicated relationships could help researchers better understand the disease pathogenesis and thus provide early potential non-invasive biomarkers, new therapeutic targets, and tools for risk stratification that might result in greater therapeutic possibilities and eventually in a better and longer patient survival.

show abstract

Effect of bacterial contamination in bile on pancreatic cancer cell survival

Cited by 17 publications

References 36 publications

A Comprehensive Review of the Current and Future Role of the Microbiome in Pancreatic Ductal Adenocarcinoma

A Comprehensive Review of the Current and Future Role of the Microbiome in Pancreatic Ductal Adenocarcinoma

Potential Roles of the Gut Microbiota in Pancreatic Carcinogenesis and Therapeutics

Impact of microbiota-immunity axis in pancreatic cancer management

Contact Info

Product

Resources

About