Epithelium of the human vocal fold as a vibrating tissue

Sato, Kiminori; Chitose, Shun‐ichi; Satô, Fumihiko; Ono, Takeharu; Umeno, Hirohito

doi:10.1016/j.anl.2020.11.011

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…In humans, only the VF is covered with this type of epithelium, but other laryngeal regions, including the vestibule, are covered with the pseudostratified ciliated epithelium 29 , 30 . The stratified squamous epithelium has a high tensile strength and is flexible, thus becoming quite resistant to mechanical stimuli and friction 29 , 30 . This feature reflects the frequent collisions of the VFs in humans.…”

Section: Resultsmentioning

confidence: 99%

Twin vocal folds as a novel evolutionary adaptation for vocal communications in lemurs

Nakamura,

Kanaya,

Matsushima

et al. 2024

Sci Rep

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Primates have varied vocal repertoires to communicate with conspecifics and sometimes other species. The larynx has a central role in vocal source generation, where a pair of vocal folds vibrates to modify the air flow. Here, we show that Madagascan lemurs have a unique additional pair of folds in the vestibular region, parallel to the vocal folds. The additional fold has a rigid body of a vocal muscle branch and it is covered by a stratified squamous epithelium, equal to those of the vocal fold. Such anatomical features support the hypothesis that it also vibrates in a manner like the vibrations that occur in the vocal folds. To examine the acoustic function of the two pairs of folds, we made a silicone compound model to demonstrate that they can simultaneously vibrate to lower the fundamental frequency and increase vocal efficiency. Similar acoustic effects are achieved using different features of the larynx for the other primates, e.g., by vibrating multiple sets of ventricular folds in several species and further by an evolutionary modification of enlarged larynx in howler monkeys. Our multidisciplinary approaches found that these functions were acquired through a unique evolutionary adaptation of the twin vocal folds in Madagascan lemurs.

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Section: Resultsmentioning

confidence: 99%

Twin vocal folds as a novel evolutionary adaptation for vocal communications in lemurs

Nakamura,

Kanaya,

Matsushima

et al. 2024

Sci Rep

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“…Regarding the epithelium of the human vocal fold, the stratified squamous epithelium seems to form a structural framework which likely has great tensile strength with mobility, extensibility and pliability resulting in a structure suitable for vibration 11) .…”

Section: Viscoelastic Properties Of the Lamina Propria Of The Human V...mentioning

confidence: 99%

声帯粘膜のmicrofibril-associated macromoleculeの超微構造

Sato,

Chitose,

Sato

et al. 2023

LARYNX JAPAN

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ヒト声帯粘膜の粘弾性は，声帯振動と発声に必須である．粘膜の粘弾性は細胞外マトリックスの質的・量的三次元構造に委ねられる．近年，フィブリリン含有の微小線維(microfibril)は，単なるフィブリリン重合体ではなく，種々の高分子が付加された構造である事が分かってきている．ヒト声帯粘膜では，微小線維と他の細胞外マトリックスとの関連性とその機能に関して十分に解明されていない．本総説では声帯粘膜の microfibril-associated macromolecule の超微構造を概説する．直径が約 10nm の微小線維はヒト声帯粘膜のラインケ腔に広く分布している．微小線維の一部は単独に存在し，他の微小線維は，膠原線維，細網線維(typeⅢ膠原線維) ，エラスチン，プロテオグリカン，グリコサミノグリカンと混在している．このことは，微小線維に伴ったタンパク質あるいは糖タンパク質は，ヒト声帯粘膜の特性や粘弾性に関与していることが示唆される．微小線維に伴ったタンパク質あるいは糖タンパク質は，微小線維単独の機能とは異なった細胞外マトリックスとしての特性や機能を保持していることが示唆される．声帯粘膜の microfibril-associated macromolecule の役割について，さらなる研究が望まれる． Keywords： microfibril-associated macromolecules, microfibril-associated protein, microfibril-associated glycoprotein, viscoelastic properties, human vocal fold mucosa

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“…Interestingly, cell junctions hold stratified squamous epithelium, which serves as a protective layer around membranous vocal folds [ 20 ]. Compared to newborn epithelial cells, adult epithelial cells displayed more significant intercellular gaps, greater mechanical strength, and more excellent elasticity [ 21 ]. In the lamina propria, the vascular network disperses differently.…”

Section: Introductionmentioning

confidence: 99%

Tissue Engineering as a Promising Treatment for Glottic Insufficiency: A Review on Biomolecules and Cell-Laden Hydrogel

Lokanathan

Baki

et al. 2022

Biomedicines

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Glottic insufficiency is widespread in the elderly population and occurs as a result of secondary damage or systemic disease. Tissue engineering is a viable treatment for glottic insufficiency since it aims to restore damaged nerve tissue and revitalize aging muscle. After injection into the biological system, injectable biomaterial delivers cost- and time-effectiveness while acting as a protective shield for cells and biomolecules. This article focuses on injectable biomaterials that transport cells and biomolecules in regenerated tissue, particularly adipose, muscle, and nerve tissue. We propose Wharton’s Jelly mesenchymal stem cells (WJMSCs), induced pluripotent stem cells (IP-SCs), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), insulin growth factor-1 (IGF-1) and extracellular vesicle (EV) as potential cells and macromolecules to be included into biomaterials, with some particular testing to support them as a promising translational medicine for vocal fold regeneration.

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Epithelium of the human vocal fold as a vibrating tissue

Cited by 5 publications

References 2 publications

Twin vocal folds as a novel evolutionary adaptation for vocal communications in lemurs

Twin vocal folds as a novel evolutionary adaptation for vocal communications in lemurs

声帯粘膜のmicrofibril-associated macromoleculeの超微構造

Tissue Engineering as a Promising Treatment for Glottic Insufficiency: A Review on Biomolecules and Cell-Laden Hydrogel

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