Distinct cardiovascular and respiratory responses to short-term sustained hypoxia in juvenile Sprague Dawley and Wistar Hannover rats

Bazilio, Darlan S.; Rodrigues, Karla Lima; Moraes, Deovaldo de; Machado, Benedito H.

doi:10.1016/j.autneu.2020.102746

Cited by 10 publications

(5 citation statements)

References 73 publications

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“…With respect to respiratory parameters recorded in behaving animals, we observed that mice submitted to SH present significant increase in respiratory frequency, tidal volume and pulmonary ventilation. These changes observed in mice are similar to those observed in juvenile rats submitted to SH (Bazilio et al., 2020; da Silva et al., 2019). These findings are also in agreement with previous studies showing similar increase in all ventilatory parameters ( f R , V T and

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E ) in response to hypoxic challenges in mice (Cramer et al., 2015; Giannakopoulou et al., 2019; Han et al., 2001; Lee & Liao, 2018; Tankersley et al., 2000).…”

Section: Discussionsupporting

confidence: 83%

Changes in the autonomic and respiratory patterns in mice submitted to short‐term sustained hypoxia

Rodrigues

Souza

Bazilio

et al. 2021

Experimental Physiology

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New Findings What is the central question of this study?Do mice submitted to sustained hypoxia present autonomic and respiratory changes similarly to rats? What is the main finding and its importance?Arterial pressure in the normal range, reduced baseline heart rate and tachypnoea were observed in behaving sustained hypoxia mice. Recordings in the in situ preparation of mice submitted to sustained hypoxia show an increase in cervical vagus nerve activity and a simultaneous reduction in thoracic sympathetic nerve activity correlated with changes in the respiratory cycle. Therefore, mice are an important model for studies on the modulation of sympathetic activity to the cardiovascular system and the vagus innervation of the upper airways due to changes in the respiratory network induced by sustained hypoxia. Abstract Short‐term sustained hypoxia (SH) in rats induces sympathetic overactivity and hypertension due to changes in sympathetic–respiratory coupling. However, there are no consistent data about the effect of SH on mice due to the different protocols of hypoxia and difficulties associated with the handling of these rodents under different experimental conditions. In situ recordings of autonomic and respiratory nerves in SH mice have not been performed yet. Herein, we evaluated the effects of SH (FnormaliO2 = 0.1 for 24 h) on baseline mean arterial pressure (MAP), heart rate (HR), respiratory frequency (fR) and responses to chemoreflex activation in behaving SH mice. A characterization of changes in cervical vagus (cVN), thoracic sympathetic (tSN), phrenic (PN) and abdominal (AbN) nerves in SH mice using the in situ working heart–brainstem preparation was also performed. SH mice presented normal MAP, significant reduction in baseline HR, increase in baseline fR, as well as increase in the magnitude of bradycardic response to chemoreflex activation. In in situ preparations, SH mice presented a reduction in PN discharge frequency, and increases in the time of expiration and incidence of late‐expiratory bursts in AbN activity. Nerve recordings also indicated a significant increase in cVN activity and a significant reduction in tSN activity during expiration in SH mice. These findings make SH mice an important experimental model for better understanding how changes in the respiratory network may impact on the modulation of vagal control to the upper airways, as well as in the sympathetic activity to the cardiovascular system.

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\overset{V}{true}

E ) in response to hypoxic challenges in mice (Cramer et al., 2015; Giannakopoulou et al., 2019; Han et al., 2001; Lee & Liao, 2018; Tankersley et al., 2000).…”

Section: Discussionsupporting

confidence: 83%

Changes in the autonomic and respiratory patterns in mice submitted to short‐term sustained hypoxia

Rodrigues

Souza

Bazilio

et al. 2021

Experimental Physiology

Self Cite

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show abstract

“…This difference is probably related to HR in the in situ preparation being intrinsic, since With respect to respiratory parameters recorded in behaving animals, we observed that mice submitted to SH present significant increase in respiratory frequency, tidal volume and pulmonary ventilation. These changes observed in mice are similar to those observed in juvenile rats submitted to SH (Bazilio et al, 2020;. These findings are also in agreement with previous studies showing similar increase in all ventilatory parameters (f R , V T and VE ) in response to hypoxic challenges in mice (Cramer et al, 2015;Giannakopoulou et al, 2019;Han et al, 2001;Lee & Liao, 2018;Tankersley et al, 2000).…”

Section: Discussionsupporting

confidence: 92%

Envolvimento das células gliais na modulação das vias neurais do quimiorreflexo periférico no núcleo do trato solitário de ratos jovens submetidos à hipóxia mantida

Bazilio¹

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“…For example, a lower dose and longer time after STZ administration can favor changes in the LC and an increased response to hypercapnia [153], while a higher dose may affect changes in the NTS region and alter the response to hypoxia [143,145]. The use of a specific strain may be important, as Wistar Hanover rats have been shown to be less sensitive to short-term hypoxia than Sprague Dawley rats [162]. Thus, for example, Wistar rats treated with STZ showed no change in their ventilatory response to hypoxia compared to controls [153,154] as opposed to Sprague Dawley rats, which had this response reduced [143].…”

Section: Altered Ventilatory Response To Hypercapniamentioning

confidence: 99%

Respiratory Dysfunction in Alzheimer’s Disease—Consequence or Underlying Cause? Applying Animal Models to the Study of Respiratory Malfunctions

Wrzesień,

Andrzejewski,

Jampolska

et al. 2024

IJMS

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Alzheimer’s disease (AD) is a neurodegenerative brain disease that is the most common cause of dementia among the elderly. In addition to dementia, which is the loss of cognitive function, including thinking, remembering, and reasoning, and behavioral abilities, AD patients also experience respiratory disturbances. The most common respiratory problems observed in AD patients are pneumonia, shortness of breath, respiratory muscle weakness, and obstructive sleep apnea (OSA). The latter is considered an outcome of Alzheimer’s disease and is suggested to be a causative factor. While this narrative review addresses the bidirectional relationship between obstructive sleep apnea and Alzheimer’s disease and reports on existing studies describing the most common respiratory disorders found in patients with Alzheimer’s disease, its main purpose is to review all currently available studies using animal models of Alzheimer’s disease to study respiratory impairments. These studies on animal models of AD are few in number but are crucial for establishing mechanisms, causation, implementing potential therapies for respiratory disorders, and ultimately applying these findings to clinical practice. This review summarizes what is already known in the context of research on respiratory disorders in animal models, while pointing out directions for future research.

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Distinct cardiovascular and respiratory responses to short-term sustained hypoxia in juvenile Sprague Dawley and Wistar Hannover rats

Cited by 10 publications

References 73 publications

Changes in the autonomic and respiratory patterns in mice submitted to short‐term sustained hypoxia

Changes in the autonomic and respiratory patterns in mice submitted to short‐term sustained hypoxia

Envolvimento das células gliais na modulação das vias neurais do quimiorreflexo periférico no núcleo do trato solitário de ratos jovens submetidos à hipóxia mantida

Respiratory Dysfunction in Alzheimer’s Disease—Consequence or Underlying Cause? Applying Animal Models to the Study of Respiratory Malfunctions

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