A population-level analysis of nonsquamous penile cancer: The importance of histology

Bhambhvani, Hriday P.; Greenberg, Daniel S.; Parham, Matthew J.

doi:10.1016/j.urolonc.2020.11.025

Cited by 5 publications

(10 citation statements)

References 18 publications

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“…Speci cally, we noted a median age at diagnosis of 68 years, highest prevalence in Caucasians (75%), and most diagnoses occurring at a localized stage (65%). These observations are particularly different from the population-based report by Bhambhvani et al, relying on the SEER database 1975-2016, in which over 42% of patients were diagnosed prior to year 2000 and without excluding non-invasive and precursor lesions [20]. For example, in this more historical report, mean age of non-SCC patients was 61 years.…”

Section: Discussioncontrasting

confidence: 79%

“…In the population-based report by Bhambhvani et al, melanoma non-SCC patients diagnosed between 1975 and 2016 displayed a CSM disadvantage relative to SCC patients. The disadvantage persisted even in the most recent subgroup of patients diagnosed between 2000 and 2016 [20]. Conversely, relying on the same methodology, no CSM differences were recorded between basal cell carcinoma vs. SCC penile cancer patients diagnosed between 2000-2016.…”

Section: Discussionmentioning

confidence: 91%

“…Within SEER database (2004 − 2016), we identi ed patients ≥ 18 years old with histologically con rmed primary penile cancer (International Classi cation of Disease for Oncology [ICD-O] site code C60.0). Histological subtype was de ned as either SCC, basal cell, melanoma, skin appendage malignancy, neuroendocrine, adenocarcinoma, lymphoma, sarcoma or as epithelial neoplasm (including non-small cell carcinoma, pseudocarcinomatous carcinoma, and undifferentiated carcinoma), according to the WHO criteria [1,9,22]. Unknown histology, penile intraepithelial neoplasia and precursor lesions such as Paget's disease were excluded.…”

Section: Study Populationmentioning

confidence: 99%

“…Most contemporary large-scale epidemiological penile cancer studies exclusively focused on SCC histological subtype [4,[10][11][12][13][14]. Only one large-scale, and several case series and case reports examined outcomes of non-SCC penile cancer [15][16][17][18][19][20]. The largest single institutional cohort of non-SCC penile cancer (1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012) consisted of 12 patients with melanoma, sarcoma, and sebaceous carcinoma histologies [17].…”

Section: Introductionmentioning

confidence: 99%

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Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma

Wenzel

Siron

Ruvolo

et al. 2021

Preprint

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Purpose:To test the effect of variant histology (non-SCC) cancer-specific mortality (CSM), relative to squamous cell carcinoma (SCC) in penile cancer patients. Methods:Within the Surveillance, Epidemiology and End Results database (2004–2016), penile cancer patients of all stages were identified. Temporal trend analyses, cumulative incidence and Kaplan-Meier plots and multivariable competing-risks regression analyses tested for CSM differences between non-SCC vs. SCC penile cancer patients.Results:Of 4,120 eligible penile cancer patients, 123 (3%) harbored non-SCC vs. 4,027 (97%) SCC. Of all non-SCC patients, 51 (41%) harbored melanomas vs. 42 (34%) basal cell carcinomas vs. 10 (8%) adenocarcinomas vs. eight (6.5%) skin appendage malignancies vs. six (5%) epithelial cell neoplasms vs. two (1.5%) neuroendocrine tumors vs. two (1.5%) lymphomas, vs. two (1.5%) sarcomas. In temporal trend analyses, non-SCC diagnoses neither decreased nor increased over time (p>0.05). After stratification according to localized, locally advanced, and metastatic stage, no CSM differences were observed between non-SCC vs. SCC, with 5-year survival rates of 11 vs 11% (p=0.9) for localized, 33 vs 37% (p=0.4) for locally advanced, and 1-year survival rates of 37 vs 53% (p=0.9) for metastatic penile cancer, respectively. After propensity score matching for patient and tumor characteristics and additional multivariable adjustment, no CSM differences between non-SCC vs. SCC were observed. Conclusion:Non-SCC penile cancer is rare. Although exceptions exist, on average, non-SCC penile cancer has comparable CSM as SCC penile cancer patients, after stratification for localized, locally invasive, and metastatic disease.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 91%

Section: Study Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma

Wenzel

Siron

Ruvolo

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma

Wenzel

Siron

Ruvolo

et al. 2021

Cancer Causes Control

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Purpose To compare Cancer-specific mortality (CSM) in patients with Squamous cell carcinoma (SCC) vs. non-SCC penile cancer, since survival outcomes may differ between histological subtypes. Methods Within the Surveillance, Epidemiology and End Results database (2004–2016), penile cancer patients of all stages were identified. Temporal trend analyses, cumulative incidence and Kaplan–Meier plots, multivariable Cox regression and Fine and Gray competing-risks regression analyses tested for CSM differences between non-SCC vs. SCC penile cancer patients. Results Of 4,120 eligible penile cancer patients, 123 (3%) harbored non-SCC vs. 4,027 (97%) SCC. Of all non-SCC patients, 51 (41%) harbored melanomas, 42 (34%) basal cell carcinomas, 10 (8%) adenocarcinomas, eight (6.5%) skin appendage malignancies, six (5%) epithelial cell neoplasms, two (1.5%) neuroendocrine tumors, two (1.5%) lymphomas, two (1.5%) sarcomas. Stage at presentation differed between non-SCC vs. SCC. In temporal trend analyses, non-SCC diagnoses neither decreased nor increased over time (p > 0.05). After stratification according to localized, locally advanced, and metastatic stage, no CSM differences were observed between non-SCC vs. SCC, with 5-year survival rates of 11 vs 11% (p = 0.9) for localized, 33 vs. 37% (p = 0.4) for locally advanced, and 1-year survival rates of 37 vs. 53% (p = 0.9) for metastatic penile cancer, respectively. After propensity score matching for patient and tumor characteristics and additional multivariable adjustment, no CSM differences between non-SCC vs. SCC were observed. Conclusion Non-SCC penile cancer is rare. Although exceptions exist, on average, non-SCC penile cancer has comparable CSM as SCC penile cancer patients, after stratification for localized, locally invasive, and metastatic disease.

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Une tumeur rare de la verge survenue dans un contexte de maladie de Lapeyronie

Olejarz

Audenet

Verkarre

2021

Annales de Pathologie

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A population-level analysis of nonsquamous penile cancer: The importance of histology

Cited by 5 publications

References 18 publications

Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma

Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma

Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma

Une tumeur rare de la verge survenue dans un contexte de maladie de Lapeyronie

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