Porcine circovirus type 2 exploits cap to inhibit PKR activation through interaction with Hsp40

Lv, Qizhuang; Wang, Tao; Liu, Shanchuan; Zhu, Yong‐Guan

doi:10.1016/j.vetmic.2020.108929

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…Furthermore, PCV2-induced endothelial IL-8 decreases the adhesion and migration of monocyte-derived DCs (MoDCs), resulting in a decrease in the maturation rate of MoDCs and further inhibition of antigen presentation by dendritic cells (DCs) [ 143 ]. Moreover, the PKR signaling pathway was activated by dsRNA generated during PCV transcription, which activates eIF2α to inhibit virus protein [ 70 , 144 ]. However, the viral cap can interact with Hsp40 DNAJC7, causing the migration of DNAJC7 to the nucleus and releasing PKR inhibitor P58 IPK from the DNAJC7-P58 IPK complex to the cytoplasm, thus inhibiting the activation of PKR [ 144 ].…”

Section: Crosstalk Between Pcv and Hostmentioning

confidence: 99%

“…Moreover, the PKR signaling pathway was activated by dsRNA generated during PCV transcription, which activates eIF2α to inhibit virus protein [ 70 , 144 ]. However, the viral cap can interact with Hsp40 DNAJC7, causing the migration of DNAJC7 to the nucleus and releasing PKR inhibitor P58 IPK from the DNAJC7-P58 IPK complex to the cytoplasm, thus inhibiting the activation of PKR [ 144 ]. These results indicate that PCV modulates inflammatory responses to inhibit antiviral responses and the maturation of immune cells.…”

Section: Crosstalk Between Pcv and Hostmentioning

confidence: 99%

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Advances in Crosstalk between Porcine Circoviruses and Host

Niu

Chen

et al. 2022

Viruses

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Porcine circoviruses (PCVs), including PCV1 to PCV4, are non-enveloped DNA viruses with a diameter of about 20 nm, belonging to the genus Circovirus in the family Circoviridae. PCV2 is an important causative agent of porcine circovirus disease or porcine circovirus-associated disease (PCVD/PCVAD), which is highly prevalent in pigs and seriously affects the swine industry globally. Furthermore, PCV2 mainly causes subclinical symptoms and immunosuppression, and PCV3 and PCV4 were detected in healthy pigs, sick pigs, and other animals. Although the pathogenicity of PCV3 and PCV4 in the field is still controversial, the infection rates of PCV3 and PCV4 in pigs are increasing. Moreover, PCV3 and PCV4 rescued from infected clones were pathogenic in vivo. It is worth noting that the interaction between virus and host is crucial to the infection and pathogenicity of the virus. This review discusses the latest research progress on the molecular mechanism of PCVs–host interaction, which may provide a scientific basis for disease prevention and control.

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Section: Crosstalk Between Pcv and Hostmentioning

confidence: 99%

Section: Crosstalk Between Pcv and Hostmentioning

confidence: 99%

Advances in Crosstalk between Porcine Circoviruses and Host

Niu

Chen

et al. 2022

Viruses

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“…ORF2 is located on the anti-sense strand of the genome and encodes the capsid (Cap) protein [17]. As the main structural protein, Cap protein contains highly conserved linear and conformational epitopes, induces host immunity and mediates immune evasion during PCV infection [18][19][20][21]. Therefore, Cap protein serves as a versatile tool for molecular diagnosis and serological surveillance.…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic Analysis and Serological Investigation of Porcine Circovirus Indicates Frequent Infection with Various Subtypes

Peng,

Shi,

Lang

et al. 2023

IJMS

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Porcine circoviruses (PCVs) are notorious for triggering severe diseases in pigs and causing serious economic losses to the swine industry. In the present study, we undertook a comprehensive approach for the investigation of PCV prevalence, including the phylogenetic analysis of obtained PCV sequences, the determination of major circulating genotypes and serological screening based on different recombinant Cap proteins with specific immunoreactivity. Epidemiological surveillance data indicate that PCV2d and PCV3a are widely distributed in Southwest China, while PCV4 has only sporadic circulation. Meanwhile, serological investigations showed high PCV2 antibody positivity in collected serum samples (>50%), followed by PCV4 (nearly 50%) and PCV3 (30–35%). The analysis supports different circulation patterns of PCV2, PCV3 and PCV4 and illustrates the PCV2/PCV3 genetic evolution characteristics on a nationwide basis. Taken together, our findings add up to the current understanding of PCV epidemiology and provide new tools and insight for PCV antiviral intervention.

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