Five-year survival in patients with nodular and superficial spreading melanomas in the US population

Allais, Blair S.; Beatson, Meghan; Wang, Hongkun; Shahbazi, Shandiz; Bijelić, Lana; Jang, Sekwon; Venna, Suraj

doi:10.1016/j.jaad.2020.11.047

Cited by 35 publications

(34 citation statements)

References 41 publications

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“…Usually, women are more active in the prevention of sun exposure on the head and neck, which may reduce the risk of HNM [8]. Histology has been reported as an important survival factor for melanoma patients [42,43]. In agreement with other studies, we observed a high frequency of LMM on the head and neck [7,9].…”

Section: Discussionsupporting

confidence: 91%

Comparing the characteristics and predicting the survival of patients with head and neck melanoma versus body melanoma: a population-based study

et al. 2021

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Background Previous studies reported cutaneous melanoma in head and neck (HNM) differed from those in other regions (body melanoma, BM). Individualized tools to predict the survival of patients with HNM or BM remain insufficient. We aimed at comparing the characteristics of HNM and BM, developing and validating nomograms for predicting the survival of patients with HNM or BM. Methods The information of patients with HNM or BM from 2004 to 2015 was obtained from the Surveillance, Epidemiology, and End Results (SEER) database. The HNM group and BM group were randomly divided into training and validation cohorts. We used the Kaplan-Meier method and multivariate Cox models to identify independent prognostic factors. Nomograms were developed via the rms and dynnom packages, and were measured by the concordance index (C-index), the area under the curve (AUC) of the receiver operating characteristic (ROC) curve and calibration plots. Results Of 70,605 patients acquired, 21% had HNM and 79% had BM. The HNM group contained more older patients, male sex and lentigo maligna melanoma, and more frequently had thicker tumors and metastases than the BM group. The 5-year cancer-specific survival (CSS) and overall survival (OS) rates were 88.1 ± 0.3% and 74.4 ± 0.4% in the HNM group and 92.5 ± 0.1% and 85.8 ± 0.2% in the BM group, respectively. Eight variables (age, sex, histology, thickness, ulceration, stage, metastases, and surgery) were identified to construct nomograms of CSS and OS for patients with HNM or BM. Additionally, four dynamic nomograms were available on web. The internal and external validation of each nomogram showed high C-index values (0.785–0.896) and AUC values (0.81–0.925), and the calibration plots showed great consistency. Conclusions The characteristics of HNM and BM are heterogeneous. We constructed and validated four nomograms for predicting the 3-, 5- and 10-year CSS and OS probabilities of patients with HNM or BM. These nomograms can serve as practical clinical tools for survival prediction and individual health management.

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Section: Discussionsupporting

confidence: 91%

Comparing the characteristics and predicting the survival of patients with head and neck melanoma versus body melanoma: a population-based study

et al. 2021

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“…As in our study, stage IV patients at first diagnosis and other melanoma subtypes besides SSM and NM were not included in the analysis. Recently, Allais et al (Allais et al 2020 ) determined the difference in 5-year relative survival in patients with NM and SSM at the same Breslow depth and TNM stage obtained from the SEER register. They showed that 5-year relative survival was worse in NM patients as compared to patients with SSM, particularly in T1b, T2a, and T2b melanomas.…”

Section: Discussionmentioning

confidence: 99%

Multivariate analysis of prognostic factors in patients with nodular melanoma

Susok

Stücker

Bechara

et al. 2021

J Cancer Res Clin Oncol

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Purpose Nodular melanoma (NM) is associated with worse disease outcome when compared to superficial spreading melanoma (SSM). We aimed to perform a single-center analysis of prognostic factors in patients with NM and compare the data with SSM patients. Methods We studied 228 patients with NN and 396 patients with SSM. Patients with in situ melanomas or stage IV at diagnosis were not included in the study. Data were analyzed using the Mann–Whitney test, Chi-square test, Kaplan–Meier curves including the log-rank test, and logistic regression model. Results When compared to patients with SSM, patients with NM had less likely lower Clark level, higher tumor thickness, less likely tumor regression, more often ulcerated tumors, and less likely a history of precursor lesions such as a nevus. Within a 5-year follow-up we observed significantly more disease relapses and deaths in NM patients than in SSM patients. On multivariate analysis, disease relapse in NM patients was independently predicted by tumor thickness and positive SLNB, whereas melanoma-specific death of NM patients was independently predicted by male sex and tumor thickness. Histologic regression also remained in the logistic regression model as a significant independent negative predictor of NM death. Conclusions We did not observe that NM subtype was per se a significant independent predictor for disease relapse or melanoma-specific death. Among the well-known prognostic factors such as tumor thickness and male sex, NM is also associated with other unfavorable factors such as absence of regression.

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“…3 As in our study, stage IV patients at rst diagnosis and other melanoma subtypes besides SSM and NM were not included in the analysis. Recently, Allais et al 13 determined the difference in 5-year relative survival in patients with NM and SSM at the same Breslow depth and TNM stage obtained from the SEER register. They showed that 5-year relative survival was worse in NM patients as compared to patients with SSM, particularly in T1b, T2a, and T2b melanomas.…”

Section: Discussionmentioning

confidence: 99%

Multivariate Analysis of Prognostic Factors in Patients With Nodular Melanoma

Susok

Stücker

Bechara

et al. 2021

Preprint

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Purpose Nodular melanoma (NM) is associated with worse disease outcome when compared to superficial spreading melanoma (SSM). We aimed to perform a single center analysis of prognostic factors in patients with NM and compare the data with SSM patients. Methods We studied 228 patients with NN and 396 patients with SSM. Patients with in-situ melanomas or stage IV at diagnosis were not included in the study. Data were analyzed using the Mann-Whitney test, Chi² test, Kaplan-Meier curves including the log-rank test, and logistic regression model.Results When compared to patients with SSM, patients with NM had less likely lower Clark level, higher tumor thickness, less likely tumor regression, more often ulcerated tumors, and less likely a history of precursor lesions such as a nevus. Within a 5-year follow-up we observed significantly more disease relapses and deaths in NM patients than in SSM patients. On multivariate analysis, disease relapse in NM patients was independently predicted by tumor thickness and positive SLNB, whereas melanom-specific death of NM patients was independently predicted by male sex and tumor thickness. Histologic regression also remained in the logistic regression model as a significant independent negative predictor of NM death.Conclusions We did not observe that NM subtype was a significant independent predictor for disease relapse or melanoma-specific death. Among the well-known prognostic factors such as tumor thickness and male sex, NM is also associated with other unfavorable factors such as absence of regression.

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Five-year survival in patients with nodular and superficial spreading melanomas in the US population

Cited by 35 publications

References 41 publications

Comparing the characteristics and predicting the survival of patients with head and neck melanoma versus body melanoma: a population-based study

Comparing the characteristics and predicting the survival of patients with head and neck melanoma versus body melanoma: a population-based study

Multivariate analysis of prognostic factors in patients with nodular melanoma

Multivariate Analysis of Prognostic Factors in Patients With Nodular Melanoma

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