Takayasu's Arteritis from the Patients' Perspectives: Measuring the Pulse to the Patient-Reported Outcomes

Luna-Vargas, Lizeth; Hinojosa, Carlos A.; Contreras-Yáñez, Irazú; Anaya‐Ayala, Javier E.; Hinojosa‐Azaola, Andrea

doi:10.1016/j.avsg.2020.10.026

Cited by 3 publications

(6 citation statements)

References 24 publications

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“…Individual SF-36 Domains Pooling data from five studies [37,39,45,51,56] (three cross- Comparisons between TAK patients and healthy controls were pooled from two studies (one each cross-sectional or cohort studies, 30 patients with TAK) [39,56]. Large effect sizes denoted worse scores in all domains for patients with TAK, with considerable heterogeneity [32]; however, the differences were not statistically significant (Fig.…”

Section: Patient-reported Outcome Measuresmentioning

confidence: 99%

“…HAQ scores C 1 indicate significant disability [12]. Six studies evaluated HAQ in TAK [40,42,45,49,51,56]. Pooled HAQ in 261 patients with TAK (two cohort, three cross-sectional studies) [40,42,45,51,56] was 0.46 (95% CI 0.37-0.55) with little heterogeneity (Fig.…”

Section: Disabilitymentioning

confidence: 99%

“…The MFI-20 assesses fatigue using 20 questions scored from 0 to 5, averaged to provide a score from 20, with higher scores indicating worse fatigue [59]. Three studies assessed MFI-20 in TAK [41,51,53]. Pooled MFI-20 score in 113 patients with TAK (one each cross-sectional and cohort study) [41,53] [41] with considerable heterogeneity (Fig.…”

Section: Fatigue Multidisciplinary Fatigue Inventorymentioning

confidence: 99%

“…Rimland et al [53] reported similar MFI-20 scores in patients with TAK and GCA. Luna-Vargas et al [51] reported the association of earlier disease duration with worse general fatigue domain scores of MFI-20 in 15 patients with TAK.…”

Section: Fatigue Multidisciplinary Fatigue Inventorymentioning

confidence: 99%

“…Excluding the study of Quartuccio et al[39], the I 2 for the domain of emotional role limitation but not for other domains was reduced to \ 50%. Excluding the study of Luna-Vargas[51] reduced I 2 to \ 50% for the domains of physical function, emotional role limitation and mental health but not for other domains. Thus, no single study adequately explained the heterogeneity.…”

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confidence: 97%

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Patient-Reported Outcome Measures in Takayasu Arteritis: A Systematic Review and Meta-Analysis

et al. 2021

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Introduction: We conducted a systematic review of patient-reported outcome measures (PROMs) regarding quality of life, disability, mood abnormalities (anxiety, depression), fatigue, illness perceptions and fibromyalgia in Takayasu arteritis (TAK). Wherever available, comparisons with healthy controls, disease controls or longitudinal changes in PROMs were noted. Methods: MEDLINE, EMBASE, Scopus, Web of Science and Pubmed Central databases, major recent international rheumatology conference abstracts, clinical trial databases and the Cochrane library were searched for relevant articles. Wherever possible, outcome measures across studies were pooled using the restricted maximum likelihood model. Inter-group differences were pooled and compared using standardized mean differences (SMD) with 95% confidence intervals (95% CI). Heterogeneity was assessed using the I 2 statistic. Quality of randomized controlled trials was assessed using the Cochrane risk of bias tool. For cross-sectional and cohort studies, the Joana Briggs Institute checklist and Newcastle-Ottawa scale were used, respectively. GRADE methodology was used to determine the certainty of evidence for outcomes. Results: Twenty-one studies (all but one observational) involving 1311 patients with TAK and 308 healthy controls were identified. Ten studies (559 TAK patients, 182 healthy controls were synthesized in a meta-analysis. Patients with TAK had worse quality of life (pooled SMD -6.66, 95% CI -10.08 to -3.23 for individual domains; -0.64, 95% CI -1.19 to -0.09 for pooled physical and mental component scores of 36-item Short Form Survey), depression (SMD 0.26, 95% 0.05-0.47) and anxiety (SMD 0.34, 95% CI -0.06 to 0.75) Durga P. Misra and Upendra Rathore are joint first authors.

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Section: Patient-reported Outcome Measuresmentioning

confidence: 99%

Section: Disabilitymentioning

confidence: 99%

Section: Fatigue Multidisciplinary Fatigue Inventorymentioning

confidence: 99%

Section: Fatigue Multidisciplinary Fatigue Inventorymentioning

confidence: 99%

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confidence: 97%

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Patient-Reported Outcome Measures in Takayasu Arteritis: A Systematic Review and Meta-Analysis

et al. 2021

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Assessment of damage in Takayasu’s arteritis

Kermani,

Sreih,

Cuthbertson

et al. 2024

Rheumatology

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Objectives To evaluate damage and clinical characteristics associated with damage in Takayasu’s arteritis (TAK). Methods Patients with TAK enrolled in a multicentre, prospective, observational study underwent standardized damage assessment every 6 months using the Vasculitis Damage Index (VDI) and the Large-Vessel Vasculitis Index of Damage (LVVID). Results The study included 236 patients with TAK: 92% female, 81% Caucasian; median (25th, 75th percentile) disease duration = 2.6 (0.12, 6.9) years. Eighty-four percent had follow-up: median (25th, 75th) duration 4.1 (1.9, 7.5) years. Items of damage were present in 89% on VDI, 87% on LVVID, in the peripheral vascular (76% VDI, 74% LVVID), cardiac (40% VDI, 45% LVVID) systems. During follow-up, 42% patients had new damage;, including major vessel stenosis/arterial occlusion (8%), limb claudication (6%), hypertension (7%), aortic aneurysm (4%), and bypass surgery (4%). Disease-specific damage accounted for >90% new items. Older age, relapse, and longer duration of follow-up were associated with new damage items; a higher proportion of patients without new damage were on methotrexate (p< 0.05). Among 48 patients diagnosed with TAK within 180 days of enrolment, new damage occurred in 31% on VDI and 52% on LVVID. History of relapse was associated with new damage in the entire cohort while in patients with a recent diagnosis, older age at diagnosis was associated with new damage. Conclusion Damage is present in > 80% of patients with TAK even with recent diagnosis and >40% of patients accrue new, mainly disease-specific damage. Therapies for TAK that better control disease activity and prevent damage should be prioritized.

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Organ Damage and Quality of Life in Takayasu Arteritis　― Evidence From a National Registry Analysis ―

Yoshifuji,

Nakaoka,

Uchida

et al. 2024

Circ J

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Background: Takayasu arteritis, affecting primarily young women, damages large arteries and organs. We examined the impact of disease duration and sex on organ damage and quality of life using Japan's Intractable Disease Registry. Methods and Results:After refining data, 2,013 of 2,795 patients were included in the study. Longer disease duration was related to a lower prevalence of disease activity symptoms, a higher prevalence of organ damage, and a higher proportion of patients requiring nursing care. Compared with men, women tended to have an earlier onset age, exhibiting longer disease duration. A higher proportion of women had aortic regurgitation and required nursing care. The proportion of female patients in employment was lower than that of the general female population, whereas no difference was observed between male patients and the general male population. Logistic regression analysis revealed that age at surveillance, brain ischemia, visual impairment/loss, and ischemic heart disease were significant factors associated with high nursing care needs (Level ≥2, with daily activity limitations). Conclusions:Early diagnosis and effective treatment, particularly to prevent brain ischemia, visual impairment, and ischemic heart disease, may improve the quality of life of patients with Takayasu arteritis, especially women.

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Takayasu's Arteritis from the Patients' Perspectives: Measuring the Pulse to the Patient-Reported Outcomes

Cited by 3 publications

References 24 publications

Patient-Reported Outcome Measures in Takayasu Arteritis: A Systematic Review and Meta-Analysis

Patient-Reported Outcome Measures in Takayasu Arteritis: A Systematic Review and Meta-Analysis

Assessment of damage in Takayasu’s arteritis

Organ Damage and Quality of Life in Takayasu Arteritis　― Evidence From a National Registry Analysis ―

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Takayasu's Arteritis from the Patients' Perspectives: Measuring the Pulse to the Patient-Reported Outcomes

Cited by 3 publications

References 24 publications

Patient-Reported Outcome Measures in Takayasu Arteritis: A Systematic Review and Meta-Analysis

Patient-Reported Outcome Measures in Takayasu Arteritis: A Systematic Review and Meta-Analysis

Assessment of damage in Takayasu’s arteritis

Organ Damage and Quality of Life in Takayasu Arteritis ― Evidence From a National Registry Analysis ―

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Product

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Organ Damage and Quality of Life in Takayasu Arteritis　― Evidence From a National Registry Analysis ―