The impact of salinity and dissolved oxygen regimes on transcriptomic immune responses to oil in early life stage Fundulus grandis

Rodgers, Maria L.; Serafin, Jennifer; Sepúlveda, Marı́a S.; Griffitt, Robert J.

doi:10.1016/j.cbd.2020.100753

Cited by 4 publications

(2 citation statements)

References 68 publications

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“…In vivo as well as in vitro studies reported that HAH or PAH exposure of fish or fish immune cells results in altered expression of pro-inflammatory cytokines like IL-1β, TNFα, IL-6, IL-8, or IFNγ [150,155,[169][170][171][172][173]. Additionally, global transcriptomic studies corroborate that exposure to AhR ligands modulates immune gene expression of fish [170,[174][175][176]. The toxicant-induced changes of immune gene transcription are not adverse by themselves, but they may have implications for the overall immune functioning of the organism.…”

Section: Immune Transcriptional Responses Of Fish To Ahr-binding Xenobioticsmentioning

confidence: 74%

Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

Segner

Bailey²,

Tafalla³

et al. 2021

IJMS

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The impact of anthropogenic contaminants on the immune system of fishes is an issue of growing concern. An important xenobiotic receptor that mediates effects of chemicals, such as halogenated aromatic hydrocarbons (HAHs) and polyaromatic hydrocarbons (PAHs), is the aryl hydrocarbon receptor (AhR). Fish toxicological research has focused on the role of this receptor in xenobiotic biotransformation as well as in causing developmental, cardiac, and reproductive toxicity. However, biomedical research has unraveled an important physiological role of the AhR in the immune system, what suggests that this receptor could be involved in immunotoxic effects of environmental contaminants. The aims of the present review are to critically discuss the available knowledge on (i) the expression and possible function of the AhR in the immune systems of teleost fishes; and (ii) the impact of AhR-activating xenobiotics on the immune systems of fish at the levels of immune gene expression, immune cell proliferation and immune cell function, immune pathology, and resistance to infectious disease. The existing information indicates that the AhR is expressed in the fish immune system, but currently, we have little understanding of its physiological role. Exposure to AhR-activating contaminants results in the modulation of numerous immune structural and functional parameters of fish. Despite the diversity of fish species studied and the experimental conditions investigated, the published findings rather uniformly point to immunosuppressive actions of xenobiotic AhR ligands in fish. These effects are often associated with increased disease susceptibility. The fact that fish populations from HAH- and PAH-contaminated environments suffer immune disturbances and elevated disease susceptibility highlights that the immunotoxic effects of AhR-activating xenobiotics bear environmental relevance.

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Section: Immune Transcriptional Responses Of Fish To Ahr-binding Xenobioticsmentioning

confidence: 74%

Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

Segner

Bailey²,

Tafalla³

et al. 2021

IJMS

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“…When hypoxia is combined with salinity stress, it seems that the direction of salinity stress (i.e. hyper- versus hyposalinity) is a determining factor as seen in euryhaline Fundulus grandis larvae (tolerance range 0–70 ppt [ 50 ]), where high salinity (30 ppt) and hypoxia (6 mg l −1 ) had no effect on immune gene expression, low salinity (3 ppt) plus hypoxia led to a suppression of immune-related gene pathways [ 142 ]. However, as this assumption is based on only one study, we suspect that life stage, species and ecotype will have an influence on the outcome.…”

Section: Interactive Effects Of Multiple Climate Change-related Stres...mentioning

confidence: 99%

Are fish immunocompetent enough to face climate change?

Franke,

Beemelmanns,

Miest

2024

Biol. Lett.

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Ongoing climate change has already been associated with increased disease outbreaks in wild and farmed fish. Here, we evaluate the current knowledge of climate change-related ecoimmunology in teleosts with a focus on temperature, hypoxia, salinity and acidification before exploring interactive effects of multiple stressors. Our literature review reveals that acute and chronic changes in temperature and dissolved oxygen can compromise fish immunity which can lead to increased disease susceptibility. Moreover, temperature and hypoxia have already been shown to enhance the infectivity of certain pathogens/parasites and to accelerate disease progression. Too few studies exist that have focussed on acidification, but direct immune effects seem to be limited while salinity studies have led to contrasting results. Likewise, multi-stressor experiments essential for unravelling the interactions of simultaneously changing environmental factors are still scarce. This ultimately impedes our ability to estimate to what extent climate change will hamper fish immunity. Our review about epigenetic regulation mechanisms highlights the acclimation potential of the fish immune response to changing environments. However, due to the limited number of epigenetic studies, overarching conclusions cannot be drawn. Finally, we provide an outlook on how to better estimate the effects of realistic climate change scenarios in future immune studies in fish.

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Physiological-dependent alterations on transcriptomic and proteomic patterns of the single and combined temperature and salinity-exposed hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂

Zheng

Jiang

et al. 2023

Aquaculture

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The impact of salinity and dissolved oxygen regimes on transcriptomic immune responses to oil in early life stage Fundulus grandis

Cited by 4 publications

References 68 publications

Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

Are fish immunocompetent enough to face climate change?

Physiological-dependent alterations on transcriptomic and proteomic patterns of the single and combined temperature and salinity-exposed hybrid grouper, Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂

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