Corrigendum to “Antimicrobial activity of synthetic Dq-3162, a 28-residue ponericin G-like dinoponeratoxin from the giant ant Dinoponera quadriceps venom, against carbapenem-resistant bacteria” [Toxicon 187 November 2020 19–28]

Present review article explains ant venom components and its allergic and biological effects in man and animals. Red ants or small fire ants secrete and inject venom very swiftly to defend their nest against predators, microbial pathogens, and competitors and to hunt the prey. Ant venom is a mixture of various organic compounds, including peptides, enzymes, and polypeptide toxins. It is highly toxic, allergic, invasive and venomous. It imposes sever paralytic, cytolytic, haemolytic, allergenic, pro-inflammatory, insecticidal, antimicrobial, and pain-producing pharmacologic activities after infliction. Victims show red ring-shaped allergic sign with regional swelling marked with intense pain. Ant venom also contains several hydrolases, oxidoreductases, proteases, Kunitz-like polypeptides, and inhibitor cysteine knot (ICK)-like (knottin) neurotoxins and insect defensins. Ant venom toxins/proteins generate allergic immune responses and employ eosinophils and produce Th2 cytokines, response. These compounds from ant venom could be used as a potential source of new anticonvulsants molecules. Ant venoms contain many small, linear peptides, an untapped source of bioactive peptide toxins. The remarkable insecticidal activity of ant venom could be used as a promising source of additional bio-insecticides and therapeutic agents.

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Toxic and Immune Allergic Responses of Ant Venom Toxins: A Review

Sharma

Upadhyay

2021

Int J Pharm Pharm Sci

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Therapeutics Approaches of Invertebrate Animal Toxins: A Review

Sharma

Upadhyay²

2022

Int J Pharm Pharm Sci

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The present review article describes invertebrate venoms and various toxins secreted by them. Animal venoms are stores of novel peptides which exhibit a wide variety of biological effects and actively interact with pathogen and parasites. Animal toxins selectively bind to ion channels and receptors and display show hemolytic, cytolytic, proteolytic, anti-diabetic, antimicrobial and analgesic activity. These generate allergic and inflammatory responses in victims. These disrupt cell membranes and inhibit bacterial growth and kill them. Animal toxins inhibit virus entry into host cells and obstruct virus replication. These were also found highly effective against protozoan and fungal pathogens. By using bioinformatics tools, methods and approaches, both structural and functional diversity of toxin peptides could be harnessed to develop highly effective broad-spectrum drugs for therapeutics. Animal venoms are an inexhaustible source of bioactive molecules, which could be used for the development of immune diagnostics, various pharmaceuticals for therapeutics and bio-insecticides. Present article tries to explore the exceptional specificity and high potency of animal toxins for drug development.

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Corrigendum to “Antimicrobial activity of synthetic Dq-3162, a 28-residue ponericin G-like dinoponeratoxin from the giant ant Dinoponera quadriceps venom, against carbapenem-resistant bacteria” [Toxicon 187 November 2020 19–28]

Cited by 2 publications

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Toxic and Immune Allergic Responses of Ant Venom Toxins: A Review

Toxic and Immune Allergic Responses of Ant Venom Toxins: A Review

Therapeutics Approaches of Invertebrate Animal Toxins: A Review

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