Water extract of Artemisia scoparia Waldst. &amp; Kitam suppresses LPS-induced cytokine production and NLRP3 inflammasome activation in macrophages and alleviates carrageenan-induced acute inflammation in mice

Ahn, Jae-Hun; Park, Yae-Lyeon; Song, Aiqin; Kim, Wan-Gyu; Je, Chang-Yun; Jung, Do-Hyeon; Kim, Yeong-Jun; Oh, Ji‐Su; Cho, Jeong-Yong; Kim, Dong-Jae; Park, Jong‐Hwan

doi:10.1016/j.jep.2020.113606

Cited by 14 publications

(10 citation statements)

References 35 publications

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“…Although the reason for this discrepancy cannot be ascertained, the three studies investigated extracts prepared from different plant material originating from diverse geographic locations, using various extraction methods and solvents, and tested at different doses; one or more of these factors could explain these seemingly conflicting results. Similar studies were conducted in isolated bone marrow-derived macrophages (BMDM) from mice, in which NO, inducible nitric oxide synthase (iNOS), and inflammatory cytokine levels were all reduced by SCOPA treatment in stimulated cells ( 69 ). Comparable effects of SCOPA have been observed in the THP-1 human monocyte cell line, undifferentiated 3T3-L1 murine preadipocytes, and in the HMC-1 human mast cell line ( 69 , 73 ).…”

Section: Effects Of a Scoparia On Determinants Of ...mentioning

confidence: 75%

“…Similar studies were conducted in isolated bone marrow-derived macrophages (BMDM) from mice, in which NO, inducible nitric oxide synthase (iNOS), and inflammatory cytokine levels were all reduced by SCOPA treatment in stimulated cells ( 69 ). Comparable effects of SCOPA have been observed in the THP-1 human monocyte cell line, undifferentiated 3T3-L1 murine preadipocytes, and in the HMC-1 human mast cell line ( 69 , 73 ). Moreover, reduced pro-inflammatory NF-κB promoter activation in IL-1β-treated pancreatic beta-cells, which are also vulnerable to obesity-related inflammation, has been observed in response to SCOPA ( 72 ).…”

Section: Effects Of a Scoparia On Determinants Of ...mentioning

confidence: 75%

“…Infiltration of macrophages and altered resident immune cell populations in adipose tissue promote inflammation and insulin resistance ( 66 , 67 ). Many conditions treated by SCOPA in TCM or folk medicine have an inflammatory component [( 41 ) and Table 1 ], and SCOPA has been shown to have anti-inflammatory properties in a wide range of conditions, including inhibition of heat-induced protein denaturation in vitro ( 68 ) and reducing inflammatory cytokine production, cell infiltration, and edema in carrageenan-induced acute inflammation in rats and mice ( 69 , 70 ). Similarly, topical application of SCOPA diminished clinical symptoms, cell infiltration, inflammatory cytokine levels, caspase-1 activity in lesions, and circulating levels of histamine in a mouse model of atopic dermatitis ( 71 ).…”

Section: Effects Of a Scoparia On Determinants Of ...mentioning

confidence: 99%

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Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

et al. 2022

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Botanicals have a long history of medicinal use for a multitude of ailments, and many modern pharmaceuticals were originally isolated from plants or derived from phytochemicals. Among these, artemisinin, first isolated from Artemisia annua, is the foundation for standard anti-malarial therapies. Plants of the genus Artemisia are among the most common herbal remedies across Asia and Central Europe. The species Artemisia scoparia (SCOPA) is widely used in traditional folk medicine for various liver diseases and inflammatory conditions, as well as for infections, fever, pain, cancer, and diabetes. Modern in vivo and in vitro studies have now investigated SCOPA’s effects on these pathologies and its ability to mitigate hepatotoxicity, oxidative stress, obesity, diabetes, and other disease states. This review focuses on the effects of SCOPA that are particularly relevant to metabolic health. Indeed, in recent years, an ethanolic extract of SCOPA has been shown to enhance differentiation of cultured adipocytes and to share some properties of thiazolidinediones (TZDs), a class of insulin-sensitizing agonists of the adipogenic transcription factor PPARγ. In a mouse model of diet-induced obesity, SCOPA diet supplementation lowered fasting insulin and glucose levels, while inducing metabolically favorable changes in adipose tissue and liver. These observations are consistent with many lines of evidence from various tissues and cell types known to contribute to metabolic homeostasis, including immune cells, hepatocytes, and pancreatic beta-cells. Compounds belonging to several classes of phytochemicals have been implicated in these effects, and we provide an overview of these bioactives. The ongoing global epidemics of obesity and metabolic disease clearly require novel therapeutic approaches. While the mechanisms involved in SCOPA’s effects on metabolic, anti-inflammatory, and oxidative stress pathways are not fully characterized, current data support further investigation of this plant and its bioactives as potential therapeutic agents in obesity-related metabolic dysfunction and many other conditions.

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Section: Effects Of a Scoparia On Determinants Of ...mentioning

confidence: 75%

Section: Effects Of a Scoparia On Determinants Of ...mentioning

confidence: 75%

Section: Effects Of a Scoparia On Determinants Of ...mentioning

confidence: 99%

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Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

et al. 2022

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“…The water extract of Artemisia scoparia inhibited NF-κB and extracellular signal-regulated kinase-mediated expression of NLRP3 and IL-1β precursor genes and proteins ( Ahn et al., 2021 ). Furthermore, the water extract of Artemisia scoparia participated in the activation response of NLRP3 inflammasome activation, inhibiting cleavage of caspase-1 and IL-1β, and inhibiting ATP- and monosodium uric acid-mediated IL-1β production ( Ahn et al., 2021 ).…”

Section: Specific Inhibitors Of Nlrp3 Inflammasomementioning

confidence: 99%

The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets

et al. 2021

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Cerebrovascular diseases are pathological conditions involving impaired blood flow in the brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid haemorrhage. The nucleotide-binding and oligomerisation (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome is a protein complex and a vital component of the immune system. Emerging evidence has indicated that the NLRP3 inflammasome plays an important role in cerebrovascular diseases. The function of the NLRP3 inflammasome in the pathogenesis of cerebrovascular diseases remains an interesting field of research. In this review, we first summarised the pathological mechanism of cerebrovascular diseases and the pathological mechanism of the NLRP3 inflammasome in aggravating atherosclerosis and cerebrovascular diseases. Second, we outlined signalling pathways through which the NLRP3 inflammasome participates in aggravating or mitigating cerebrovascular diseases. Reactive oxygen species (ROS)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), ROS/thioredoxin-interacting protein (TXNIP) and purinergic receptor-7 (P2X7R) signalling pathways can activate the NLRP3 inflammasome; activation of the NLRP3 inflammasome can aggravate cerebrovascular diseases by mediating apoptosis and pyroptosis. Autophagy/mitochondrial autophagy, nuclear factor E2-related factor-2 (Nrf2), interferon (IFN)-β, sirtuin (SIRT), and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) reportedly alleviate cerebrovascular diseases by inhibiting NLRP3 inflammasome activation. Finally, we explored specific inhibitors of the NLRP3 inflammasome based on the two-step activation of the NLRP3 inflammasome, which can be developed as new drugs to treat cerebrovascular diseases.

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“…Artemisia scoparia Waldst.et Kit, a perennial plant in the Asteraceae family, grows on sandy beaches and is known to possess anti-inflammatory and antioxidant effects (22)(23)(24). Although natural products each have their own health benefits, several studies have been reported that show synergistic effects when they are used as a mixture (25,26).…”

Section: Introductionmentioning

confidence: 99%

Anti‑inflammatory effect of red ginseng marc, Artemisia scoparia, Paeonia japonica and Angelica gigas extract mixture in LPS‑stimulated RAW 264.7 cells

et al. 2022

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A normal inflammatory response is essential in protecting the body from foreign substances. However, excessive inflammation contributes to diseases such as oxidative stress, heart disease, and cancer. In this study, we evaluated the anti-inflammatory effects of RAPA (red ginseng marc, Artemisia scoparia Waldst.et Kit, Paeonia japonica Miyabe & Takeda, and Angelica gigas Nakai extract mixture) in LPS-stimulated RAW 264.7 cells (macrophages). RAPA suppressed the expression of inflammatory factors such as iNOS and COX-2 and decreased the production of nitric oxide. In addition, RAPA decreased the expression of the inflammatory cytokines TNF-α and IL-6. Furthermore, RAPA inhibited the phosphorylation of MAPKs such as JNK and ERK as well as IκB and NF-κB. In conclusion, RAPA inhibited production of inflammatory mediators via downregulation of the MAPK and NF-κB signaling pathways in LPS-stimulated RAW 264.7 cells. The results of this study demonstrated that RAPA regulates excessive inflammatory responses at the cellular level. Therefore, it is necessary to investigate whether the same effect is observed in vivo through further research.

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Water extract of Artemisia scoparia Waldst. & Kitam suppresses LPS-induced cytokine production and NLRP3 inflammasome activation in macrophages and alleviates carrageenan-induced acute inflammation in mice

Cited by 14 publications

References 35 publications

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets

Anti‑inflammatory effect of red ginseng marc, Artemisia scoparia, Paeonia japonica and Angelica gigas extract mixture in LPS‑stimulated RAW 264.7 cells

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