Comparison of long-term survival outcome after curative hepatectomy between selected patients with non-colorectal and colorectal liver metastasis: A propensity score matching analysis

Lok, Hon‐Ting; Fung, A.; Chong, Charing C.N.; Lee, Kit‐Fai; Wong, John; Cheung, Siu Wun; Lai, Paul; Ng, Kelvin K.

doi:10.1016/j.asjsur.2020.10.019

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…Thus, we were not able to identify any factors that significantly impaired overall survival following surgery on NCRNNELM. This finding was in line with the recent publications of Patkar et al and Lok et al with similar sample sizes [ 37 , 38 ]. This suggested that patients with NCRNNELM could benefit from radical treatment in the long run.…”

Section: Discussionsupporting

confidence: 93%

Surgery for Liver Metastasis of Non-Colorectal and Non-Neuroendocrine Tumors

Katou

Schmid

Silveira

et al. 2022

JCM

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Surgery has become well established for patients with colorectal and neuroendocrine liver metastases. However, the value of this procedure in non-colorectal and non-neuroendocrine metastases (NCRNNELMs) remains unclear. We analyzed the outcomes of patients that underwent liver surgery for NCRNNELMs and for colorectal liver metastases (CRLMs) between 2012 and 2017 at our institution. Prognostic factors of overall and recurrence-free survival were analyzed, and a comparison of survival between two groups was performed. Seventy-three patients (30 NCRNNELM and 43 CRLM) were included in this study. Although the mean age, extrahepatic metastases, and rate of reoperation were significantly different between the groups, recurrence-free survival was comparable. The 5-year overall survival rates were 38% for NCRNNELM and 55% for CRLM. In univariate analysis, a patient age of ≥60 years, endodermal origin of the primary tumor, and major complications were negative prognostic factors. Resection for NCRNNELM showed comparable results to resection for CRLM. Age, the embryological origin of the primary tumor, and the number of metastases might be the criteria for patient selection.

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Section: Discussionsupporting

confidence: 93%

Surgery for Liver Metastasis of Non-Colorectal and Non-Neuroendocrine Tumors

Katou

Schmid

Silveira

et al. 2022

JCM

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“…LR remains the only potentially curative option for patients with liver metastasis. Although there are no clear oncological indications several studies have shown overlapping results between LR for colorectal versus noncolorectal metastases (78,79).…”

Section: Renal Cellmentioning

confidence: 99%

Non-colorectal non-neuroendocrine liver metastasis: a narrative review of surgical treatment

Basso¹,

Usai²,

Sandri³

2022

Chin Clin Oncol

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Background and Objective: The liver is the main site of metastatic disease, and cancer metastases remain the main limit to successfully managing the malignant disease. Liver resection (LR) for the treatment of metastatic cancer has been described for over a hundred years and is widely accepted. The role of surgery in managing non-colorectal non-neuroendocrine liver metastasis (NCNNLM), evidence is still lacking due to different factors: the paucity of cases, the wide variety of histological subtypes of the primary disease and its biological behavior, and the absence of prospective studies.Methods: We performed a narrative review of peer-reviewed articles related to the surgical outcomes of NCNNLM. The aim of this review is determining the utility of surgery in NCNNLM, with attention to minimal invasive LRs. We analyzed the role of LR for NCNNLM according to the different cancers: digestive and non digestive.Key Content and Findings: NCNNLM encompass a huge spectrum of histologic appearances. LR for limited NCNNLM may offer a curative option, but liver recurrence occurs frequently. Our ability to significantly predict the outcome is poor. Conclusions:The cytotoxic chemotherapy and biologic agents have significantly altered the surgical treatment of LM. The latter treatments can convert inoperable patients into operable ones, with a clear relationship between the degree of resectability in patients judged inoperable at referral and the rate of response to the treatment scheme.

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