Assessment of a liposomal CT/optical contrast agent for image-guided head and neck surgery

Muhanna, Nidal; Eu, Donovan; Chan, Harley; Daly, Michael J.; Fricke, Inga B.; Douglas, Catriona; Townson, Jason L.; Zheng, Jinzi; Allen, Christine; Jaffray, David A.; Irish, Jonathan C.

doi:10.1016/j.nano.2020.102327

Cited by 5 publications

(17 citation statements)

References 29 publications

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“…However, if CTL fails to identify a SLN by 24–48 h p.i. then re-injection should be considered with repeat imaging performed within 24 h. This finding is similar with other studies, in which CF800 was evaluated ( 30 , 31 ). In these studies, CF800 was injected intravenously in a rabbit model and was retained within the primary tumor up to 8 days p.i ( 30 ) and 10 days p.i.…”

Section: Discussionsupporting

confidence: 88%

“…In these studies, CF800 was injected intravenously in a rabbit model and was retained within the primary tumor up to 8 days p.i ( 30 ) and 10 days p.i. ( 31 ). Second tier lymph nodes were identified as early as 1 day post-injection, so the potential for second tier drainage must be considered if there is a prolonged period between injection and the study.…”

Section: Discussionmentioning

confidence: 99%

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Evaluating the Feasibility and Efficacy of a Dual-Modality Nanoparticle Contrast Agent (Nanotrast-CF800) for Image-Guided Sentinel Lymph Node Mapping in the Oral Cavity of Healthy Dogs

et al. 2021

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A combination of pre and intraoperative sentinel lymph node (SLN) mapping techniques have been suggested to optimize SLN detection. A novel liposomal nanoparticle, Nanotrast-CF800 (CF800), utilizes computed tomography lymphography (CTL) and near infrared fluorescence imaging (NIRF) for image-guided surgery and SLN mapping. This novel tracer agent has not been evaluated in companion animals. The objective of this study was to evaluate the feasibility and efficacy of CF800 for SLN mapping in the oral cavity of healthy dogs and to report any local adverse effects. Six healthy adult purpose-bred research dogs randomly received either 1 mL (group 1) or 2 mL (group 2) of CF800 injected into the submucosa at the level of the right canine maxillary tooth. CTL and percutaneous NIRF were performed at 1, 3, and 10 min, then 1, 2, 4, 7, and 10 days post-injection (p.i). Overall, both CTL and NIRF identified SLNs in all dogs. The overall peak mean contrast enhancement of the SLNs was 73.98 HU (range 63.45–86.27 HU) at 2 days p.i. Peak fluorescence of the SLN occurred at 1 day p.i. The agent was retained within the SLN for at least 7 days for CTL and 4 days for percutaneous NIRF. No adverse effects were observed. Local administration of CF800 was simple and feasible for the detection of SLNs using CTL+NIRF in the head and neck of healthy dogs and was not associated with significant local adverse events.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Evaluating the Feasibility and Efficacy of a Dual-Modality Nanoparticle Contrast Agent (Nanotrast-CF800) for Image-Guided Sentinel Lymph Node Mapping in the Oral Cavity of Healthy Dogs

et al. 2021

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“…This finding is similar with other studies, in which CF800 was evaluated. 31,32 In these studies, CF800 was injected intravenously in a rabbit model and was retained within the primary tumor up to 8 days p.i 31 and 10 days p.i. 32 Second tier lymph nodes were identified as early as 1 day post-injection, so the potential for second tier drainage must be considered if there is a prolonged period between injection and the study.…”

Section: Discussionmentioning

confidence: 99%

“…Second-and third-tier SLNs were defined as lymph nodes that were not contrast enhanced when the SLN(s) was identified but were enhanced on subsequent scans. The degree of fluorescence intensity was determined based on a semi-quantitative scoring system on a scale from 0 -3+ (0 = no fluorescence, 1+ = mild fluorescence, 2+ = moderate fluorescence, 3+ = marked fluorescence) 26 Videos and images were recorded from the NIR exoscope. Dogs were then reversed using atipamezole IM.…”

Section: Methodsmentioning

confidence: 99%

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Evaluating the feasibility and efficacy of a dual-modality nanoparticle contrast agent (Nanotrast-CF800) for image-guided sentinel lymph node mapping in the oral cavity of healthy dogs

Wan

Oblak

Ram

et al. 2021

Preprint

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A combination of pre- and intraoperative sentinel lymph node (SLN) mapping techniques have been suggested to optimize SLN detection. A novel liposomal nanoparticle, Nanotrast-CF800 (CF800), utilizes computed tomography lymphography (CTL) and near infrared fluorescence imaging (NIRF) for image-guided surgery and SLN mapping. This novel tracer agent has not been evaluated in companion animals. The objective of this study was to evaluate the feasibility and efficacy of CF800 for SLN mapping in the oral cavity of healthy dogs and to report any local adverse effects. Six healthy adult purpose-bred research dogs randomly received either 1 mL (group 1) or 2 mL (group 2) of CF800 injected into the submucosa at the level of the right canine maxillary tooth. CTL and percutaneous NIRF were performed at 1, 3, and 10 minutes, then 1, 2, 4, 7, and 10 days post-injection (p.i). Overall, both CTL and NIRF identified SLNs in all dogs. The overall peak mean contrast enhancement of the SLNs was 73.98 HU (range 63.45-86.27 HU) at 2 days p.i. Peak fluorescence of the SLN occurred at 1 day p.i. The agent was retained within the SLN for at least 7 days for CTL and 4 days for NIRF. No adverse effects were observed. Local administration of CF800 was simple and feasible for the detection of SLNs using CTL+NIRF in the head and neck of healthy dogs and was not associated with significant local adverse events.

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An incremental registration method for endoscopic sinus and skull base surgery navigation: From phantom study to clinical trials

Fan

et al. 2022

Medical Physics

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Purpose Surface‐based image‐to‐patient registration in current surgical navigation is mainly achieved by a 3D scanner, which has several limitations in clinical practice such as uncontrollable scanning range, complicated operation, and even high failure rate. An accurate, robust, and easy‐to‐perform image‐to‐patient registration method is urgently required. Methods An incremental point cloud registration method was proposed for surface‐based image‐to‐patient registration. The point cloud in image space was extracted from the computed tomography (CT) image, and a template matching method was applied to remove the redundant points. The corresponding point cloud in patient space was incrementally collected by an optically tracked pointer, while the nearest point distance (NPD) constraint was applied to ensure the uniformity of the collected points. A coarse‐to‐fine registration method under the constraints of coverage ratio (CR) and outliers ratio (OR) was then proposed to obtain the optimal rigid transformation from image to patient space. The proposed method was integrated in the recently developed endoscopic navigation system, and phantom study and clinical trials were conducted to evaluate the performance of the proposed method. Results The results of the phantom study revealed that the proposed constraints greatly improved the accuracy and robustness of registration. The comparative experimental results revealed that the proposed registration method significantly outperform the scanner‐based method, and achieved comparable accuracy to the fiducial‐based method. In the clinical trials, the average registration duration was 1.24 ± 0.43 min, the target registration error (TRE) of 294 marker points (59 patients) was 1.25 ± 0.40 mm, and the lower 97.5% confidence limit of the success rate of positioning marker points exceeds the expected value (97.56% vs. 95.00%), revealed that the accuracy of the proposed method significantly met the clinical requirements (TRE ⩽ 2 mm, p < 0.05). Conclusions The proposed method has both the advantages of high accuracy and convenience, which were absent in the scanner‐based method and the fiducial‐based method. Our findings will help improve the quality of endoscopic sinus and skull base surgery.

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Assessment of a liposomal CT/optical contrast agent for image-guided head and neck surgery

Cited by 5 publications

References 29 publications

Evaluating the Feasibility and Efficacy of a Dual-Modality Nanoparticle Contrast Agent (Nanotrast-CF800) for Image-Guided Sentinel Lymph Node Mapping in the Oral Cavity of Healthy Dogs

Evaluating the Feasibility and Efficacy of a Dual-Modality Nanoparticle Contrast Agent (Nanotrast-CF800) for Image-Guided Sentinel Lymph Node Mapping in the Oral Cavity of Healthy Dogs

Evaluating the feasibility and efficacy of a dual-modality nanoparticle contrast agent (Nanotrast-CF800) for image-guided sentinel lymph node mapping in the oral cavity of healthy dogs

An incremental registration method for endoscopic sinus and skull base surgery navigation: From phantom study to clinical trials

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