Lactoferrin coated or conjugated nanomaterials as an active targeting approach in nanomedicine

Agwa, Mona M.; Sabra, Sally

doi:10.1016/j.ijbiomac.2020.11.107

Cited by 32 publications

(27 citation statements)

References 133 publications

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“…These delivery systems must consider the surface properties and receptors of the target cell, the properties of the carrier and the suitable ligand to be utilised. Moreover, a targeted drug delivery system should be non-immunogenic, biocompatible, specific to the target site, and show chemical and physical stability, both in vitro and in vivo [ 73 ].…”

Section: Resultsmentioning

confidence: 99%

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Development of Encapsulation Strategies and Composite Edible Films to Maintain Lactoferrin Bioactivity: A Review

2021

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Lactoferrin (LF) is a whey protein with various and valuable biological activities. For this reason, LF has been used as a supplement in formula milk and functional products. However, it must be considered that the properties of LF can be affected by technological treatments and gastrointestinal conditions. In this article, we have revised the literature published on the research done during the last decades on the development of various technologies, such as encapsulation or composite materials, to protect LF and avoid its degradation. Multiple compounds can be used to conduct this protective function, such as proteins, including those from milk, or polysaccharides, like alginate or chitosan. Furthermore, LF can be used as a component in complexes, nanoparticles, hydrogels and emulsions, to encapsulate, protect and deliver other bioactive compounds, such as essential oils or probiotics. Additionally, LF can be part of systems to deliver drugs or to apply certain therapies to target cells expressing LF receptors. These systems also allow improving the detection of gliomas and have also been used for treating some pathologies, such as different types of tumours. Finally, the application of LF in edible and active films can be effective against some contaminants and limit the increase of the natural microbiota present in meat, for example, becoming one of the most interesting research topics in food technology.

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Section: Resultsmentioning

confidence: 99%

“…In the active strategy, drug-loaded nanocarriers are conjugated with a certain ligand, which can further bind to a specific receptor on the surface of target cells. This receptor is normally overexpressed in the affected cells by the disease and consequently, the drug accumulates on them [ 73 ].…”

Section: Resultsmentioning

confidence: 99%

Development of Encapsulation Strategies and Composite Edible Films to Maintain Lactoferrin Bioactivity: A Review

2021

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“…This suggests that LF is an excellent ligand in the field of nanomedicine that can deliver substances to the brain [ 31 , 32 ]. These properties of LF are used in the design of targeted drug delivery systems that can percolate cancer cells or cross the brain barrier [ 30 , 31 , 33 , 34 ]. LF can be used to treat glioblastoma.…”

Section: The Role Of Milk Proteins In the Functioning Of The Bodymentioning

confidence: 99%

“…By reducing the level of arachidonic acid (ARA), CLA can influence the growth of cancer cells. For this reason, rats treated with the LF–CLA complex showed significantly lower levels of TNF-α [ 30 ]. Similar results regarding the effect of CLA on oxidative stress, MDA levels and ARA levels have also been observed in other studies [ 66 , 67 ].…”

Section: The Importance Of Fatty Acidsmentioning

confidence: 99%

“…Additionally, LF has the ability to inhibit the proliferation of cancer cells [18]. LF can bind to transferrin receptors (TFR) and LF membrane internalization receptors (LFR) that are characteristic of cancer cells [30]. The expression of the LF receptor occurs in the capillaries of the brain; additionally, LF has the ability to cross the blood-brain barrier.…”

Section: The Role Of Milk Proteins In the Functioning Of The Bodymentioning

confidence: 99%

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Importance of Bioactive Substances in Sheep’s Milk in Human Health

Flis

Molik

2021

IJMS

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Sheep’s milk is an important source of bioactive substances that have health-promoting functions for the body. The valuable composition of sheep’s milk is due to the high content of fatty acids, immunoglobulins, proteins, hormones, vitamins and minerals. Many biopeptides found in milk have antibacterial, antiviral and anti-inflammatory properties. The bioactive substances of sheep’s milk also show anticancer properties. Sheep’s milk, thanks to its content of CLA and orotic acid, prevents the occurrence of type 2 diabetes, Alzheimer’s disease and cancer. Sheep’s milk, as a product rich in bioactive substances, can be used as a medical aid to support the body in the fight against neurological and cancer diseases.

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Regulation of HeLa cell proliferation and apoptosis by bovine lactoferrin

Shu,

Su,

Zhao

et al. 2023

Cell Biochemistry & Function

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Cervical cancer is one of the foremost common cancers in women. Lactoferrin (LF) has many biological functions, such as antitumor. This study aimed to explore the regulatory effect of bovine lactoferrin (bLF) on the proliferation and apoptosis of cervical cancer HeLa cells and to clarify the potential mechanism of action of bLF against HeLa cells. This study used CCK‐8, Trypan blue staining, and colony formation assays to verify the effect of bLF on HeLa cell proliferation. Hoechst 33258 fluorescence staining, AO/EB staining, and western blotting were used to determine the effects of bLF on apoptosis and autophagy in HeLa cells. We discovered that bLF significantly reduced the proliferation of HeLa cells in a dose‐ and time‐dependent manner compared to the control group. Furthermore, bLF primarily induced apoptosis in HeLa cells by increasing the expression of the proapoptotic proteins p53, Bax, and Cleaved‐caspase‐3 and downregulating the expression of the antiapoptotic protein Bcl‐2. In addition, the present study also showed that bLF treatment significantly activated autophagy‐related proteins LC3B‐II and Beclin I and down regulated the autophagosome transporter protein p62, indicating that bLF treatment can induce autophagy in HeLa cells. After pretreatment with the autophagy inhibitor, 3‐MA, which markedly found that autophagy inhibition by 3‐MA reversed bLF‐induced apoptosis, indicating that bLF can induce apoptosis by activating intracellular autophagy in HeLa cells. In the present study, our results support the theory of bLF significantly inhibited the proliferation of Hela cells by promoting apoptosis and reinforcing autophagy. The study will play an important role in therapying cervical cancer.

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Lactoferrin coated or conjugated nanomaterials as an active targeting approach in nanomedicine

Cited by 32 publications

References 133 publications

Development of Encapsulation Strategies and Composite Edible Films to Maintain Lactoferrin Bioactivity: A Review

Development of Encapsulation Strategies and Composite Edible Films to Maintain Lactoferrin Bioactivity: A Review

Importance of Bioactive Substances in Sheep’s Milk in Human Health

Regulation of HeLa cell proliferation and apoptosis by bovine lactoferrin

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