Acute Coronary Syndrome in the Era of SARS-CoV-2 Infection: A Registry of the French Group of Acute Cardiac Care

Koutsoukis, Athanasios; Delmas, Clément; Roubille, François; Bonello, Laurent; Schurtz, Guillaume; Manzo-Silberman, Stéphane; Puymirat, Étienne; Elbaz, Meyer; Bouisset, Frédéric; Meunier, Pierre-Alain; Huet, Fabien; Paganelli, Franck; Laine, Marc; Lemesle, Gilles; Lamblin, Nicolas; Henry, Patrick; Tea, Victoria; Gallet, Romain; Teíger, Emmanuel; Huguet, R; Fard, Damien; Lim, Pascal

doi:10.1016/j.cjco.2020.11.003

Cited by 11 publications

(6 citation statements)

References 20 publications

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“…A summary of the main characteristics of these 13 studies and the baseline characteristics of all study subjects is presented in Tables 2A , B . One study originated from Poland ( 19 ), two each from the United Kingdom ( 24 , 28 ), France ( 18 , 21 ), Turkey ( 20 , 30 ), Italy ( 25 , 26 ), and Spain ( 27 , 29 ), and the remaining two studies ( 22 , 23 ) were international studies. The NOS score for all included studies varied from 5 to 8 points.…”

Section: Resultsmentioning

confidence: 99%

Comparison of the Characteristics, Management, and Outcomes of STEMI Patients Presenting With vs. Those of Patients Presenting Without COVID-19 Infection: A Systematic Review and Meta-Analysis

Wang

Kang

Chien³

et al. 2022

Front. Cardiovasc. Med.

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ObjectivesThis study aimed to investigate the differences in the characteristics, management, and clinical outcomes of patients with and that of those without coronavirus disease 2019 (COVID-19) infection who had ST-segment elevation myocardial infarction (STEMI).MethodsDatabases including Web of Science, PubMed, Cochrane Library, and Embase were searched up to July 2021. Observational studies that reported on the characteristics, management, or clinical outcomes and those published as full-text articles were included. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of all included studies.ResultsA total of 27,742 patients from 13 studies were included in this meta-analysis. Significant delay in symptom onset to first medical contact (SO-to-FMC) time (mean difference = 23.42 min; 95% CI: 5.85–40.99 min; p = 0.009) and door-to-balloon (D2B) time (mean difference = 12.27 min; 95% CI: 5.77–18.78 min; p = 0.0002) was observed in COVID-19 patients. Compared to COVID-19 negative patients, those who are positive patients had significantly higher levels of C-reactive protein, D-dimer, and thrombus grade (p < 0.05) and showed more frequent use of thrombus aspiration and glycoprotein IIbIIIa (Gp2b3a) inhibitor (p < 0.05). COVID-19 positive patients also had higher rates of in-hospital mortality (OR = 5.98, 95% CI: 4.78–7.48, p < 0.0001), cardiogenic shock (OR = 2.75, 95% CI: 2.02–3.76, p < 0.0001), and stent thrombosis (OR = 5.65, 95% CI: 2.41–13.23, p < 0.0001). They were also more likely to be admitted to the intensive care unit (ICU) (OR = 4.26, 95% CI: 2.51–7.22, p < 0.0001) and had a longer length of stay (mean difference = 4.63 days; 95% CI: 2.56–6.69 days; p < 0.0001).ConclusionsThis study revealed that COVID-19 infection had an impact on the time of initial medical intervention for patients with STEMI after symptom onset and showed that COVID-19 patients with STEMI were more likely to have thrombosis and had poorer outcomes.

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Section: Resultsmentioning

confidence: 99%

Comparison of the Characteristics, Management, and Outcomes of STEMI Patients Presenting With vs. Those of Patients Presenting Without COVID-19 Infection: A Systematic Review and Meta-Analysis

Wang

Kang

Chien³

et al. 2022

Front. Cardiovasc. Med.

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“…A similar comparative study of patients from the ORPKI database was conducted by Siudak et al In the data from 2 months of 2020, there were no differences in the time from first medical contact to balloon inflation, onset of pain to first medical contact, onset of pain to balloon inflation, or first medical contact to balloon inflation [ 12 ]. Koutsoukis et al performed a comparative analysis on a relatively small group of patients with ACS ( n = 121, COVID-19(+) n = 9, COVID-19(−) n = 112) and found no differences in the time to revascularization between the groups [ 18 ]. The psychological aspect of the late arrival of COVID-19(−) patients for invasive diagnostics is known from previous publications and can be observed in the form of fewer invasive cardiology procedures being performed [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

The Most Relevant Factors Affecting the Perioperative Death Rate in Patients with Acute Coronary Syndrome and COVID-19, Based on Annual Follow-Up in the ORPKI Registry

et al. 2021

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Background: The COVID-19 pandemic is significantly affecting the functioning of the entire healthcare system. The disease itself may be associated with thromboembolic complications. The purpose of this study is to compare patients with acute coronary syndrome (ACS) and patients with ACS who were diagnosed with COVID-19 in terms of their clinical profile, management, treatment complications, and prognosis. Methods: We analyzed 47,940 cases of patients treated for ACS in 2020, including 44,952 patients (93.8%) who were not diagnosed with COVID-19 and 2988 patients (6.2%) who tested positive for COVID-19. Results: Patients with COVID-19 were significantly more likely to experience out-of-hospital sudden cardiac arrest (7.9 vs. 1.1%; p < 0.0001) and be transported directly to a catheterization laboratory (21.3% vs. 8.1%; p < 0.0001). Mortality was significantly higher in this group (0.9% vs. 0.4%; p < 0.0001). The risk of perioperative death was increased by age over 65 years, use of glycoprotein IIb/IIIa inhibitors (GPI IIb/IIIa), femoral access, critical left main stem coronary artery (LMCA) vascular lesions, ST elevation myocardial infarction (STEMI), and no-reflow phenomenon. Conclusions: Despite the pandemic, patients with COVID-19 were treated equally to healthy patients. Efficient organization of the healthcare system allowed the prompt transportation of patients to catheterization laboratories. The study group was characterized by a worse prognosis that was affected by multiple factors.

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“…However, other potential factors could have accounted for this rise in mortality. First, some deaths are probably related to complications of COVID-19 (with a death rate between 26.9% and 27.6%) as previously reported [24] , [25] . Second, the acute management of STEMI patients could have been different during this critical period.…”

Section: Discussionmentioning

confidence: 68%

ST-segment elevation myocardial infarction: Management and association with prognosis during the COVID-19 pandemic in France

Bonnet

Panagides

Becker

et al. 2021

Archives of Cardiovascular Diseases

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Acute Coronary Syndrome in the Era of SARS-CoV-2 Infection: A Registry of the French Group of Acute Cardiac Care

Cited by 11 publications

References 20 publications

Comparison of the Characteristics, Management, and Outcomes of STEMI Patients Presenting With vs. Those of Patients Presenting Without COVID-19 Infection: A Systematic Review and Meta-Analysis

Comparison of the Characteristics, Management, and Outcomes of STEMI Patients Presenting With vs. Those of Patients Presenting Without COVID-19 Infection: A Systematic Review and Meta-Analysis

The Most Relevant Factors Affecting the Perioperative Death Rate in Patients with Acute Coronary Syndrome and COVID-19, Based on Annual Follow-Up in the ORPKI Registry

ST-segment elevation myocardial infarction: Management and association with prognosis during the COVID-19 pandemic in France

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