Arsenic-induced differential expression of oxidative stress and secondary metabolite content in two genotypes of Andrographis paniculata

Das, Paurabi; Khare, Puja; Singh, R. P.; Yadav, Vineet; Tripathi, Pratibha; Kumar, Anuj; Pandey, Vivek; Gaur, Pooja; Singh, Asha; Das, Ram; Hiremath, Channayya; Verma, Ashutosh Kumar; Shukla, Ashutosh K.; Shanker, Karuna

doi:10.1016/j.jhazmat.2020.124302

Cited by 21 publications

(8 citation statements)

References 41 publications

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“…The increase in the pharmacologically active compounds upon heavy metal treatments was attributable to the defense mechanism operating against heavy metal stress, as stress conditions generally catalyze secondary metabolite formation. These results align with earlier findings (Das et al, 2020; Jain et al, ). The metal chelating ability of polyphenols and flavonoids (Ali et al, 2020) prevents the metals from stimulating the formation of ROS.…”

Section: Discussionsupporting

confidence: 93%

“…Likewise, proline, a proteinogenic amino acid necessary for the primary plant metabolism, acts as an osmolyte as well as a defensive, and signaling molecule. Hence, its accumulation demonstrated the tolerance of plants for heavy metal stress (Das et al, 2020; Jain et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…In addition, due to their different physiology and the large diversity in the chemical class and biosynthesis pathways of pharmacologically active compounds, different MPs could have a differential response for biochar amendments under metal stress. The alteration of pharmacologically active compounds in different MPs under metal stress has been previously reported (Abbas, Rizwan, et al, 2017; Das et al, 2020); however, little information is available on the safe production of medicinal herbs and the concentration of their pharmacologically active compounds in biochar‐amended metal contaminated soil (Jain et al, 2017, 2020; Nigam et al, 2019). There are many reports on the ameliorative effect of biochar on the plants grown under metal treatments (Lee et al, 2019; Simiele et al, 2021; Wei et al, 2021), but no study reported the impact of biochar on the production of pharmacologically active compounds and health hazards associated with Pb and Cd in MPs.…”

Section: Introductionmentioning

confidence: 96%

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Biochar amendment reduced the risk associated with metal uptake and improved metabolite content in medicinal herbs

Nigam

Khare

Ahsan

et al. 2021

Physiologia Plantarum

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Contaminations of heavy metals such as lead (Pb) and cadmium (Cd) in medicinal plants (MPs) not only restrict their safe consumption due to health hazards but also lower their productivity. Biochar amendments in the soil are supposed to immobilize the toxic metals, improve the soil quality, and agricultural productivity. However, the impact of biochar on growth attributes, metal accumulation, pharmacologically active compounds of MPs, and health risk is less explored. An experiment was performed on three medicinal plants [Bacopa monnieri (L.), Andrographis paniculata (Burmf.) Nees, and Withania somnifera (L.)] grown in a greenhouse in soil co‐contaminated with Pb and Cd (at two concentrations) without and with biochar amendments (2% and 4% application rates). The fractionation of Pb and Cd, plant growth parameters, stress enzymes, photosynthetic capacity, pharmacologically active compounds, nutrient content, uptake and translocation of metals, antioxidant activities, and metabolite content were examined in the three MPs. The accumulation of Pb and Cd varied from 3.25–228 and 1.29–20.2 mg kg−1, respectively, in the three MPs, while it was reduced to 0.08–18 and 0.03–6.05 mg kg−1upon biochar treatments. Plants grown in Pb and Cd co‐contaminated soil had reduced plant biomass (5%–50% depending on the species) compared to control and a deleterious effect on photosynthetic attributes and protein content. However, biochar amendments significantly improved plant biomass (21%–175%), as well as photosynthesis attributes, chlorophyll, and protein contents. Biochar amendments in Pb and Cd co‐contaminated soil significantly reduced the health hazard quotient (HQ) estimated for the consumption of these medicinal herbs grown on metal‐rich soil. An enhancement in secondary metabolite content and antioxidant properties was also observed upon biochar treatments. These multiple beneficial effects of biochar supplementation in Pb and Cd co‐contaminated soil suggested that a biochar amendment is a sustainable approach for the safe cultivation of MPs.

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Section: Discussionsupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Biochar amendment reduced the risk associated with metal uptake and improved metabolite content in medicinal herbs

Nigam

Khare

Ahsan

et al. 2021

Physiologia Plantarum

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“…Overall, identified metabolites were found to play a major role in the positive regulation of Fe-deficiency response (Zhang et al, 2019d). Das et al (2021) investigated the differential expression of two Andrographis paniculata genotypes under As stress. The As distribution was found to be higher in roots than in other tissues with TF <1.…”

Section: Metabolomicsmentioning

confidence: 99%

“… Das et al (2021) investigated the differential expression of two Andrographis paniculata genotypes under As stress. The As distribution was found to be higher in roots than in other tissues with TF <1.…”

Section: Seven-(omics)-based Approaches To Improve Toxic Metals/metalloids Tolerance In Plantsmentioning

confidence: 99%

Advances in “Omics” Approaches for Improving Toxic Metals/Metalloids Tolerance in Plants

et al. 2022

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Food safety has emerged as a high-urgency matter for sustainable agricultural production. Toxic metal contamination of soil and water significantly affects agricultural productivity, which is further aggravated by extreme anthropogenic activities and modern agricultural practices, leaving food safety and human health at risk. In addition to reducing crop production, increased metals/metalloids toxicity also disturbs plants’ demand and supply equilibrium. Counterbalancing toxic metals/metalloids toxicity demands a better understanding of the complex mechanisms at physiological, biochemical, molecular, cellular, and plant level that may result in increased crop productivity. Consequently, plants have established different internal defense mechanisms to cope with the adverse effects of toxic metals/metalloids. Nevertheless, these internal defense mechanisms are not adequate to overwhelm the metals/metalloids toxicity. Plants produce several secondary messengers to trigger cell signaling, activating the numerous transcriptional responses correlated with plant defense. Therefore, the recent advances in omics approaches such as genomics, transcriptomics, proteomics, metabolomics, ionomics, miRNAomics, and phenomics have enabled the characterization of molecular regulators associated with toxic metal tolerance, which can be deployed for developing toxic metal tolerant plants. This review highlights various response strategies adopted by plants to tolerate toxic metals/metalloids toxicity, including physiological, biochemical, and molecular responses. A seven-(omics)-based design is summarized with scientific clues to reveal the stress-responsive genes, proteins, metabolites, miRNAs, trace elements, stress-inducible phenotypes, and metabolic pathways that could potentially help plants to cope up with metals/metalloids toxicity in the face of fluctuating environmental conditions. Finally, some bottlenecks and future directions have also been highlighted, which could enable sustainable agricultural production.

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Arsenic Induced Responses in Plants

Ghosal¹,

Chatterjee²,

Ganguly

et al. 2022

Arsenic in Plants

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Arsenic-induced differential expression of oxidative stress and secondary metabolite content in two genotypes of Andrographis paniculata

Cited by 21 publications

References 41 publications

Biochar amendment reduced the risk associated with metal uptake and improved metabolite content in medicinal herbs

Biochar amendment reduced the risk associated with metal uptake and improved metabolite content in medicinal herbs

Advances in “Omics” Approaches for Improving Toxic Metals/Metalloids Tolerance in Plants

Arsenic Induced Responses in Plants

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