Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study

Song, Yanqing; Hu, Tingting; Gao, Huan; Zhai, Jinghui; Gong, Jiawei; Zhang, Yueming; Tao, Lina; Sun, Jingmeng; Li, Zhiyuan; Qu, Xiaoyu

doi:10.1016/j.bcp.2020.114299

Cited by 31 publications

(22 citation statements)

References 35 publications

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“…The medicinal fungus, Phellinus linteus, has the effect of protecting kidneys and resisting hyperuricemia, which is mainly related to beta-alanine metabolism [41]. In addition, astragaloside can mediate anti-cisplatin-induced acute kidney injury in rats, and the related renal metabolic pathway also involves glutathione metabolism [42]. It can be seen that the above metabolic pathways are likely to be the key pathways by which lycopene interferes with nephritis.…”

Section: Discussionmentioning

confidence: 99%

Lycopene-Loaded Bilosomes Ameliorate High-Fat Diet-Induced Chronic Nephritis in Mice through the TLR4/MyD88 Inflammatory Pathway

Liu

Wang

et al. 2022

Foods

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Chronic kidney disease caused by a high-fat diet (HFD)-induced metabolic syndrome has received widespread attention. Lycopene has a wide range of biological activities and can improve a variety of chronic diseases through anti-inflammatory effects. In this study, HFD-fed mice were used as a metabolic syndrome model to evaluate the protective effect of lycopene in a sustained-release vehicle (bilosomes) in the small intestine against renal injury and to determine whether the TLR4/MyD88 pathway and related metabolic pathways are involved in this process. The results showed that lycopene bilosomes alleviated HFD-induced kidney damage, as evidenced by lower serum urea nitrogen, creatinine, and uric acid levels. Histopathology studies showed that lycopene bilosomes attenuated HFD-induced tubular cell and glomerular injury. In addition, Elisa, RT-PCR, and Western blotting results showed that lycopene bilosomes also reduced the expression of inflammatory factors such as TLR4, MyD88, NF-kB, TNF-a, and IL-6 in mouse kidneys. The mechanism was to attenuate renal inflammatory response by inhibiting the TLR4/MyD88 inflammatory pathway. These findings suggested that lycopene can alleviate nephritis and metabolic disorders caused by HFD, inhibiting the TLR4/MyD88 inflammatory pathway and its downstream pro-inflammatory cytokines and further regulating the vitamin K metabolism, beta-alanine metabolism, and glutathione metabolism pathways to relieve chronic nephritis.

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Section: Discussionmentioning

confidence: 99%

Lycopene-Loaded Bilosomes Ameliorate High-Fat Diet-Induced Chronic Nephritis in Mice through the TLR4/MyD88 Inflammatory Pathway

Liu

Wang

et al. 2022

Foods

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“…According to the accurate ion masses, retention times, standard compounds, and in-house database, a total of 20 significantly altered metabolites were identified from the MS analysis. 18,19 The metabolites are listed in Table S1. The relative levels in the content of potential biomarkers are shown in Figure 4.…”

Section: ■ Resultsmentioning

confidence: 99%

“…Among the volcano plots, each point represents a compound: green indicates that the differential metabolite was downregulated, red indicates that it was upregulated, and black indicates that there was no significant change. According to the accurate ion masses, retention times, standard compounds, and in-house database, a total of 20 significantly altered metabolites were identified from the MS analysis. , The metabolites are listed in Table S1. The relative levels in the content of potential biomarkers are shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

Metabolomic Study on Iohexol-Induced Nephrotoxicity in Rats Based on NMR and LC–MS Analyses

Wang

Huang

Zhu

et al. 2022

Chem. Res. Toxicol.

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Iohexol, the raw material of nonionic X-ray computed tomography (X-CT) contrast medium, is usually injected into the vein before CT angiography diagnosis. It is used for angiography, urography, and lymphography. With the advantages of low contrast density and good tolerance, it is currently one of the most popular contrast media. However, the renal toxicity of iohexol seriously affects its safety use. Therefore, it is of great importance to identify new potential diagnostic biomarkers and therapeutic targets in the process of contrast medium-induced acute kidney injury (CI-AKI) in order to safely use iohexol in clinical practice. In this study, in order to understand the metabolic mechanism of CI-AKI, ultra-high-performance liquid chromatography/quadrupole-Orbitrap-mass spectrometry and 1 H NMR-based metabolomic techniques were utilized to study the metabolic spectra of kidney, plasma, and urine from CI-AKI rats, and a total of 30 metabolites that were closely related to kidney injury were screened out, which were mainly related to 9 metabolic pathways. The results further indicated that iohexol might intensify kidney dysfunction in vivo by disrupting the metabolic pathways in the body, especially through blocking energy metabolism, amino acid metabolism, and promoting inflammatory reactions.

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“…In this study, the aberrant citric acid indicated the dysfunction of TCA cycle, which might be induced by the disrupted butanoate metabolism wherein l -glutamic acid and GABA were up-regulated in the kidney, cerebral cortex, and liver. Additionally, the glyoxylate and dicarboxylate metabolism pathway contributes to the TCA cycle in the energy metabolism process [ 30 ]. This study identified that the glyoxylate and dicarboxylate metabolism pathway was disrupted in the kidney, cerebral cortex, and liver, suggesting that disrupted l -glutamic acid and glyoxylate and dicarboxylate metabolism was implicated in the dysfunction of TCA cycle, leading to energy metabolism dysfunction.…”

Section: Discussionmentioning

confidence: 99%

A GC–MS-based untargeted metabolomics approach for comprehensive metabolic profiling of vancomycin-induced toxicity in mice

Zhu¹,

Wang²,

Liu³

et al. 2022

Heliyon

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Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study

Cited by 31 publications

References 35 publications

Lycopene-Loaded Bilosomes Ameliorate High-Fat Diet-Induced Chronic Nephritis in Mice through the TLR4/MyD88 Inflammatory Pathway

Lycopene-Loaded Bilosomes Ameliorate High-Fat Diet-Induced Chronic Nephritis in Mice through the TLR4/MyD88 Inflammatory Pathway

Metabolomic Study on Iohexol-Induced Nephrotoxicity in Rats Based on NMR and LC–MS Analyses

A GC–MS-based untargeted metabolomics approach for comprehensive metabolic profiling of vancomycin-induced toxicity in mice

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