Probiotics have minimal effects on appetite-related hormones in overweight or obese individuals: A systematic review of randomized controlled trials

Cabral, Ludmilla Quaresma Teixeira; Ximenez, Jaine Alves; Moreno, Karyne Garcia Tafarelo; Fernandes, Ricardo

doi:10.1016/j.clnu.2020.10.028

Cited by 10 publications

(5 citation statements)

References 62 publications

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“…Another series of studies demonstrated that administration of prebiotics and probiotics have the ability to regulate food intake and ameliorate obesity and associated disorders in humans and experimental animals [208][209][210] (Table 1). However, the effects of probiotics on appetite-related hormones and appetite in obese and overweight subjects are inconsistent, which has been reviewed elsewhere recently [211]. Thus, future studies with high methodological quality and low risk of bias are needed to determine precise the effects of probiotics on appetite regulation.…”

Section: Clinical Relevancementioning

confidence: 99%

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

et al. 2021

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Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders.

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Section: Clinical Relevancementioning

confidence: 99%

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

et al. 2021

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“…10 The long-term effects of probiotics on other appetite-related hormones, such as leptin and adiponectin, however, are yet to be established. 11…”

Section: Diet-gut Microbiome Interaction In Cancer Developmentmentioning

confidence: 99%

“…A recent systematic review and meta-analysis including 26 randomized controlled trials (RCTs) and 1720 individuals showed a significant effect of probiotics in reducing body weight, body mass index, waist circumference, fat mass, and fasting insulin levels 10 . The long-term effects of probiotics on other appetite-related hormones, such as leptin and adiponectin, however, are yet to be established 11 …”

Section: Diet-gut Microbiome and Crc Studies In Humansmentioning

confidence: 99%

Microbiome and Diet in Colon Cancer Development and Treatment

Kato

Sun

2023

Cancer J

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Diet plays critical roles in defining our immune responses, microbiome, and progression of human diseases. With recent progress in sequencing and bioinformatic techniques, increasing evidence indicates the importance of diet-microbial interactions in cancer development and therapeutic outcome. Here, we focus on the epidemiological studies on diet-bacterial interactions in the colon cancer. We also review the progress of mechanistic studies using the experimental models. Finally, we discuss the limits and future directions in the research of microbiome and diet in cancer development and therapeutic outcome. Now, it is clear that microbes can influence the efficacy of cancer therapies. These research results open new possibilities for the diagnosis, prevention, and treatment of cancer. However, there are still big gaps to apply these new findings to the clinical practice.

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“…( 2017 ) reported that the gut microbiota could influence bile acid metabolism and produce different metabolites, including short‐chain fatty acids, neuroactive, and negligible protein sequences, which can be translocated to the peripheral circulation or interact with enteroendocrine cells and the nervous system, and lead to stimulating the release of neuropeptides and peripheral hormones related to appetite and eating behavior (Van de Wouw et al., 2017 ). Depending on probiotic strains, doses, genetics, and microbial constitutions, probiotics have a different effect on appetite (Cabral et al., 2020 ). Therefore, probiotics and prebiotics in functional foods can prolong satiety time by claiming to reduce appetite.…”

Section: Large Intestinementioning

confidence: 99%

The significance and potential of functional food ingredients for control appetite and food intake

Esmaeili

Ajami

Barati

et al. 2022

Food Science & Nutrition

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Dramatically rising global levels of obesity have raised consumers’ commercial and public health interest in foods that may help control appetite and weight. The satiety cascade consists of sensory, cognitive, physical, and hormonal events following food intake, preventing overeating, and the desire to eat for a long time. Functional foods can be one of the most influential factors in reducing appetite as long as effective ingredients, such as fiber and protein, are used to design these products. Also, functional foods should be designed to reduce appetite at different levels of oral processing, stomach, small intestine, and large intestine by various mechanisms. Therefore, the satiety power of functional foods depends on the type of ingredients and their amount. Because each compound has a different mechanism of action, it is recommended to use different compounds to influence satiety in functional foods.

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Probiotics have minimal effects on appetite-related hormones in overweight or obese individuals: A systematic review of randomized controlled trials

Cited by 10 publications

References 62 publications

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

Microbiome and Diet in Colon Cancer Development and Treatment

The significance and potential of functional food ingredients for control appetite and food intake

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