Antiplatelet and anticoagulation therapy after revascularization for lower extremity artery disease: a national survey and literature overview

Ipema, Jetty; Brand, A.R.T.; Borst, Gert J. de; Vries, Jean-Paul de; Ünlü, Çağdaş

doi:10.23736/s0021-9509.20.11402-2

Cited by 4 publications

(5 citation statements)

References 43 publications

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“…Fibronectin-modified surfaces are able to capture platelets via β1 and αIIbβ3 integrins, probably resulting in increased thrombogenicity [ 89 , 90 , 91 , 92 ], which might be counterweighted by platelet-derived EC growth factors, which in turn stimulate the growth of endothelial cells [ 77 , 93 ], which has already been shown by Stronck et al with regard to endothelialization of SDVGs [ 94 ]. Also, platelet adhesion after vascular interventions is controlled by the standard administration of antiplatelet drugs [ 95 , 96 ], which might further lower the prothrombogenic effect of fibronectin coating.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation on Impacts of Fibronectin, Heparin–Chitosan, and Albumin Coating of Bacterial Nanocellulose Small-Diameter Vascular Grafts on Endothelialization In Vitro

et al. 2021

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In this study, we contrast the impacts of surface coating bacterial nanocellulose small-diameter vascular grafts (BNC-SDVGs) with human albumin, fibronectin, or heparin–chitosan upon endothelialization with human saphenous vein endothelial cells (VEC) or endothelial progenitor cells (EPC) in vitro. In one scenario, coated grafts were cut into 2D circular patches for static colonization of a defined inner surface area; in another scenario, they were mounted on a customized bioreactor and subsequently perfused for cell seeding. We evaluated the colonization by emerging metabolic activity and the preservation of endothelial functionality by water soluble tetrazolium salts (WST-1), acetylated low-density lipoprotein (AcLDL) uptake assays, and immune fluorescence staining. Uncoated BNC scaffolds served as controls. The fibronectin coating significantly promoted adhesion and growth of VECs and EPCs, while albumin only promoted adhesion of VECs, but here, the cells were functionally impaired as indicated by missing AcLDL uptake. The heparin–chitosan coating led to significantly improved adhesion of EPCs, but not VECs. In summary, both fibronectin and heparin–chitosan coatings could beneficially impact the endothelialization of BNC-SDVGs and might therefore represent promising approaches to help improve the longevity and reduce the thrombogenicity of BNC-SDVGs in the future.

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Section: Discussionmentioning

confidence: 99%

Comparative Evaluation on Impacts of Fibronectin, Heparin–Chitosan, and Albumin Coating of Bacterial Nanocellulose Small-Diameter Vascular Grafts on Endothelialization In Vitro

et al. 2021

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“…Fibronectin-modified surfaces are able to capture platelets β1 and αIIbβ3 integrins, probably resulting in increased thrombogenicity [89][90][91][92], which might be counterweighted by platelet-derived EC growth factors, which in turn stimulate the growth of endothelial cells [77,93], which has been by Stronck et al with regard to endothelialization of SDVGs [94]. Also, platelet adhesion after vascular interventions is controlled by the standard administration of antiplatelet drugs [95,96], which might further lower the prothrombogenic effect of coating. Nevertheless, heparin and heparin-chitosan coating have also generally been shown to enhance the proliferation of ECs in vitro [22,97].…”

Section: Discussionmentioning

confidence: 99%

“…Challenges in the development of artificial extracellular matrix materials include adequate engagement of cell attachment, proliferation, migration, and differentiation, and their ability to transport biomolecules and waste metabolites from native tissue. Recently, extrusion 3D printing of cell-free or cell-loaded hydrogel ink has led to the production of desired compositions and architectures for tissue-engineering applications [96]. However, most biomaterials on their own lack the inherent mechanical properties required to maintain their structural integrity and support stress factors in an in vivo 3D environment [97].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Synthesis, Applications and Biological Impact of Nanocellulose

2022

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Cover image courtesy of Rajesh Sunasee and Karina Ckless © 2022 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications.The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND.

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“…Antiplatelet agents can be prescribed as single antiplatelet therapy (SAPT) or dual antiplatelet therapy (DAPT). Different surveys among interventionalists worldwide have, however, shown that there is wide variety in prescription patterns [7][8][9][10]. Whereas most preferred DAPT over SAPT, especially after stenting, the current Global Vascular Guideline, a 2019 international guideline by the European Society for Vascular Surgery, the Society for Vascular Surgery, and the World Federation of Vascular Societies, does not provide a specific recommendation for DAPT after infrainguinal stenting [11].…”

Section: Introductionmentioning

confidence: 99%

“…To date, there is no clear-cut answer whether DAPT should be preferred over SAPT after endovascular treatment of the superficial femoral artery (SFA), with or without (drug-eluting) stents [13]. This paucity of data is also recognized for treatment of below-the-knee (BTK) arteries, with a preference in current practice for DAPT in the more distally located lesions [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Short-Term Clinical Outcomes of Single Versus Dual Antiplatelet Therapy after Infrainguinal Endovascular Treatment for Peripheral Arterial Disease

Ipema

Welling

Bakker

et al. 2020

JCM

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After infrainguinal endovascular treatment for peripheral arterial disease (PAD), it is uncertain whether single antiplatelet therapy (SAPT) or dual antiplatelet therapy (DAPT) should be preferred. This study investigated major adverse limb events (MALE) and major adverse cardiovascular events (MACE) between patients receiving SAPT and DAPT. Patient data from three centers in the Netherlands were retrospectively collected and analyzed. All patients treated for PAD by endovascular revascularization of the superficial femoral, popliteal, or below-the-knee (BTK) arteries and who were prescribed acetylsalicylic acid or clopidogrel, were included. End points were 1-, 3-, and 12-month MALE and MACE, and bleeding complications. In total, 237 patients (258 limbs treated) were included, with 149 patients receiving SAPT (63%) and 88 DAPT (37%). No significant differences were found after univariate and multivariate analyses between SAPT and DAPT on 1-, 3-, and 12-month MALE and MACE, or bleeding outcomes. Subgroup analyses of patients with BTK treatment showed a significantly lower 12-month MALE rate when treated with DAPT (hazard ratio 0.33; 95% confidence interval 0.12–0.95; p = 0.04). In conclusion, although patient numbers were small, no differences were found between SAPT and DAPT regarding MALE, MACE, or bleeding complications. DAPT should, however, be considered over SAPT for the subgroup of patients with below-the-knee endovascular treatment.

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Antiplatelet and anticoagulation therapy after revascularization for lower extremity artery disease: a national survey and literature overview

Cited by 4 publications

References 43 publications

Comparative Evaluation on Impacts of Fibronectin, Heparin–Chitosan, and Albumin Coating of Bacterial Nanocellulose Small-Diameter Vascular Grafts on Endothelialization In Vitro

Comparative Evaluation on Impacts of Fibronectin, Heparin–Chitosan, and Albumin Coating of Bacterial Nanocellulose Small-Diameter Vascular Grafts on Endothelialization In Vitro

Synthesis, Applications and Biological Impact of Nanocellulose

Short-Term Clinical Outcomes of Single Versus Dual Antiplatelet Therapy after Infrainguinal Endovascular Treatment for Peripheral Arterial Disease

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