Targeting the microbiome-gut-brain axis for improving cognition in schizophrenia and major mood disorders: A narrative review

Bioque, Miquel; González-Rodríguez, Alexandre; García-Rizo, Clemente; Cobo, Jesús; Monreal, José Antonio; Usall, Judith; Soria, Virginia; Labad, Javier

doi:10.1016/j.pnpbp.2020.110130

Cited by 37 publications

(17 citation statements)

References 135 publications

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“…The first one relates to the matter of how the different BS dimensions are related to each other and how the BMI variable mediates in such a relationship. Secondly, the extent to which Microbiome-Gut-Brain Axis ( Bioque et al, 2020 ) is related to BS along with other mental illnesses, including how stress-related hormones are related to inflammatory markers, should be explored, as well as the way such an interaction may affect mood disorders ( Schatzberg, 2015 ; Soria et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, a fat-rich diet causes leptin resistance ( Carlo et al, 2007 ). All these factors could be related to the connection between brain and gut, known as brain-gut axis, where it is depicted how microbiomes influence the brain and some psychiatric pathologies associated with emotions and cognition ( Bioque et al, 2020 ).…”

Section: Theoretical Framework: Relationships Among Bs Dimensions Andmentioning

confidence: 99%

“…Recent advances have found relationships between the BS and BMI in obese managers, for example ( Armenta-Hernández et al, 2018 ) and those that relate microbiome, brain and gut activity, (brain-gut axis). Furthermore, the contributions of those authors that have studied the mental disorders such as ( Bioque et al, 2020 ). It is important to test the possible mediating role of BMI in the relationships among the BS dimensions; specifically, the core dimensions (EE and cynicism) with PE, which would be more related to productivity, in the sense that workers with low PE would reduce their motivation and consequently their productivity ( Banerjee, 2015 ).…”

Section: Theoretical Framework: Relationships Among Bs Dimensions Andmentioning

confidence: 99%

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The Relationship Between the Burnout Syndrome Dimensions and Body Mass Index as a Moderator Variable on Obese Managers in the Mexican Maquiladora Industry

et al. 2021

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Burnout syndrome (BS) and obesity are two growing conditions that affect employees’ health and company productivity. Recently, several studies have pointed to a possible relationship between both phenomena. However, such a relationship has not been clearly defined. This research analyzes the relationship between BS dimensions and body mass index (BMI), the latter being treated as a moderator variable among obese senior and middle managers in the Mexican maquiladora industry through a structural equation model. A total of 361 senior and middle managers (124 of them classified as obese under the World Health Organization’s criteria) completed both the Maslach Burnout Inventory-General Survey [with emotional exhaustion (EE), cynicism, and professional efficacy (PE) as subscale dimensions] and a sociodemographic questionnaire (which included BMI). The results showed a statistically significant relationship between EE and PE (P < 0.001; β = -0.320), with BMI acting as a moderator variable. The results showed that when BMI increases as a moderator variable, the strength of the relationship between EE and PE also changes. For example, although PE had a negative value of 0.14 before the moderator effect, the value increased up to 0.32 when the BMI was factored into the relationship. Therefore, maquiladora industries are being advised to increase their investments on the identification and prevention of employees’ EE and obesity. Such interventions would promote a better quality of life and could prevent economic losses resulting from poor employee performance.

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Section: Discussionmentioning

confidence: 99%

Section: Theoretical Framework: Relationships Among Bs Dimensions Andmentioning

confidence: 99%

Section: Theoretical Framework: Relationships Among Bs Dimensions Andmentioning

confidence: 99%

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The Relationship Between the Burnout Syndrome Dimensions and Body Mass Index as a Moderator Variable on Obese Managers in the Mexican Maquiladora Industry

et al. 2021

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“…In addition, the pathogenesis of gut microbial shifts in gastrointestinal disorders have been confirmed (Lasheras et al, 2020;Singh et al, 2021). The increasing evidence shows that mood disorders are closely related to the dysfunction of microbe-gut-brain axis (Bioque et al, 2021) through exciting sympathetic nerves, reducing vagus nerve tension and creating brain-gut interactions (Tremblay et al, 2021). Second, the circadian abnormalities are part of the pathogenic cascade to mood disorder, FGIDs patients with mood disorders were more likely to suffer the rhythm disruptions, which aggravated their symptoms of anxiety and depression (Adibi et al, 2016;Jones et al, 2017;Murray et al, 2020).…”

Section: Analysis Of the Differences Of The Psychological Problems Bementioning

confidence: 95%

The difference of disrupted rhythms of life, work and entertainment between patients with FGIDs and healthy people and their associations with psychological disorders under COVID-19 pandemic

Wang

Deng

et al. 2021

Int J Soc Psychiatry

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Aims: To investigate the differences in disrupted rhythms between healthy people and patients with functional gastrointestinal disorders (FGIDs) and their associations with mood disorders during the coronavirus disease 2019 (COVID-19) pandemic. Methods: The rhythm scales were composed of subscales 1 and 2 for the assessment of life-work and entertainment rhythms, respectively; Zung’s Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to assess mood disorders. Results: A total of 671 patients with FGIDs and 4373 healthy people successfully participated. The scores of subscales 1 and 2 for patients with FGIDs were significantly higher than those for healthy people ( p < .005). The SAS and SDS scores, their prevalence rates were significantly higher than those for the healthy group (all p < .001). Health status, current occupation, life-work rhythm, SDS, and SAS were independent related factors of FGIDs. The score of life-work-entertainment rhythm was significantly positively correlated with SDS and SAS (both p < .001). Conclusion: Disrupted rhythms in patients with FGIDs under the COVID-19 pandemic were more frequently and significantly positively associated with mood disorders.

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“…The biological effect on the central nervous system of leptin, adiponectin, ghrelin, cholescytokinin (CCK), neuropeptide Y (NPY), glucagon like protein I (GLP-I), and insulin has accumulated further evidence (31). Initially involved in energy balance, appetite, and food intake, its effects have been later extended to synaptic plasticity, cognition, and symptomatology (32).…”

mentioning

confidence: 99%

Targeting the microbiome-gut-brain axis for improving cognition in schizophrenia and major mood disorders: A narrative review

Cited by 37 publications

References 135 publications

The Relationship Between the Burnout Syndrome Dimensions and Body Mass Index as a Moderator Variable on Obese Managers in the Mexican Maquiladora Industry

The Relationship Between the Burnout Syndrome Dimensions and Body Mass Index as a Moderator Variable on Obese Managers in the Mexican Maquiladora Industry

The difference of disrupted rhythms of life, work and entertainment between patients with FGIDs and healthy people and their associations with psychological disorders under COVID-19 pandemic

Antipsychotic-Induced Weight Gain and Clinical Improvement: A Psychiatric Paradox

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