Transient stiffening of cartilage during joint articulation: A microindentation study

Yuh, Catherine; Michel, Laurent; Espinosa‐Marzal, Rosa M.; Chubinskaya, Susan; Wimmer, Markus A.

doi:10.1016/j.jmbbm.2020.104113

Cited by 4 publications

(2 citation statements)

References 57 publications

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“…Compared to immature cartilage, mature cartilage has a hierarchal architecture that contributes to an increased mechanical stiffness and increased stability of the extracellular matrix network 30 . These characteristics are known to play roles in the tissue's capacity to bear load [31][32][33] . This may have implications on how the tissue responds to abnormal loading incurred by repetitive joint injury, as occurs in FAIS.…”

Section: Discussionmentioning

confidence: 99%

Tissue expression in surgically retrieved cam deformity and capsule from patient hips with Cam-type Femoroacetabular Impingement Syndrome

Yuh,

Malloy,

Mell

et al. 2024

Preprint

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IntroductionCam-type femoroacetabular impingement syndrome (FAIS) is a pre-arthritic hip condition, defined as a bony growth on the proximal femur that causes abnormal joint contact. The tissue presentation of the cam deformity and capsule in FAIS remains understudied. The purpose of this study was to 1) evaluate histopathological features in cam deformity and capsule from FAIS patients, 2) assess the extent of local inflammation within the capsule, and 3) determine relationships between cam deformity tissue composition versus α angle and patient factors.MethodsCam deformity and capsular tissues were collected from FAIS patients undergoing arthroscopic surgery. Samples were histologically processed, imaged using light and polarized light microscopy, and assessed with point counting. Correlation-based statistics were performed to identify features correlated with α angle and patient factors.ResultsAcross 21 cam deformity samples assessed, a total of 16,259 points were counted. The tissue within the cam deformity was observed to be heterogeneous between specimens, comprised of 16 distinct structures spanning different states of viability. In samples with articular cartilage, the tissue was highly disrupted and/or calcified. The presence of fibrocartilage, necrotic cartilage, and vasculature had significant low-moderate correlations with α angle. During assessment of capsular tissue quality, synovitis was observed in most samples.ConclusionThe cam deformity is complex and heterogeneous, both within individual cam deformities and between individuals with FAIS. Several cam deformity tissue features were correlated with α angle, age, sex, and BMI. The heterogeneity observed in these samples indicates that tissue properties within the cam deformity varies between patients with FAIS, which may contribute to outcomes of hip arthroscopic surgery and a patient’s level of risk for the subsequent development of osteoarthritis. Our findings suggest distinct tissue phenotypes of FAIS exist, which may be an important consideration for FAIS treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Tissue expression in surgically retrieved cam deformity and capsule from patient hips with Cam-type Femoroacetabular Impingement Syndrome

Yuh,

Malloy,

Mell

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

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“…(Guo et al 2022 ) This study measured the micro-elasticity of the surface of porcine cartilage using a novel nanoindentation device. (Boi, et al 2019 , Guo et al 2022 , Wang et al 2014 , Yuh et al 2021 ) The method offers high precision and accuracy, and provides deeper insight into the nanomechanical properties of the cartilage tissue. Furthermore, anisotropic and nonlinear biomechanical properties of cartilage structure and composition are generated during compression and tension.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical properties of articular cartilage in different regions and sites of the knee joint: acquisition of osteochondral allografts

Ma,

Lin,

Wang

et al. 2024

Cell Tissue Bank

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Osteochondral allograft (OCA) transplantation involves grafting of natural hyaline cartilage and supporting subchondral bone into the cartilage defect area to restore its biomechanical and tissue structure. However, differences in biomechanical properties and donor-host matching may impair the integration of articular cartilage (AC). This study analyzed the biomechanical properties of the AC in different regions of different sites of the knee joint and provided a novel approach to OCA transplantation. Intact stifle joints from skeletally mature pigs were collected from a local abattoir less than 8 h after slaughter. OCAs were collected from different regions of the joints. The patella and the tibial plateau were divided into medial and lateral regions, while the trochlea and femoral condyle were divided into six regions. The OCAs were analyzed and compared for Young’s modulus, the compressive modulus, and cartilage thickness. Young’s modulus, cartilage thickness, and compressive modulus of OCA were significantly different in different regions of the joints. A negative correlation was observed between Young's modulus and the proportion of the subchondral bone (r = − 0.4241, P < 0.0001). Cartilage thickness was positively correlated with Young’s modulus (r = 0.4473, P < 0.0001) and the compressive modulus (r = 0.3678, P < 0.0001). During OCA transplantation, OCAs should be transplanted in the same regions, or at the closest possible regions to maintain consistency of the biomechanical properties and cartilage thickness of the donor and recipient, to ensure smooth integration with the surrounding tissue. A 7 mm depth achieved a higher Young's modulus, and may represent the ideal length.

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Microindentation of Cartilage Before and After Articular Loading in a Bioreactor: Assessment of Length-Scale Dependency Using Two Analysis Methods

et al. 2021

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Transient stiffening of cartilage during joint articulation: A microindentation study

Cited by 4 publications

References 57 publications

Tissue expression in surgically retrieved cam deformity and capsule from patient hips with Cam-type Femoroacetabular Impingement Syndrome

Tissue expression in surgically retrieved cam deformity and capsule from patient hips with Cam-type Femoroacetabular Impingement Syndrome

Biomechanical properties of articular cartilage in different regions and sites of the knee joint: acquisition of osteochondral allografts

Microindentation of Cartilage Before and After Articular Loading in a Bioreactor: Assessment of Length-Scale Dependency Using Two Analysis Methods

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